Patents by Inventor Shinn Chih Wu

Shinn Chih Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Porcine pancreatic amylase gene promoter and transgenic pigs expressing heterologous digestive enzymes
    Patent number: 7956238
    Abstract: The present invention relates to a novel promoter and its use in driving expression of foreign genes in transgenic animals (especially pigs). Accordingly, the present invention provides a method for producing transgenic animals harboring heterologous genes regulated by the promoter of the present invention.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: June 7, 2011
    Assignee: National Taiwan University (An University of Taiwan, R.O.C.)
    Inventors: Teng-Kuei Winston Cheng, Shinn-Chih Wu, Chi-Chen Hsu, Yu-Sheng Lin, Chih-Jen Lin, Kuo-Joan Cheng, Jih-Tay Hsu
  • Transgenic mammal secreting B-domain deleted human FVII in its milk
    Patent number: 7667089
    Abstract: Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concentrates. The risk of transmitting blood-borne viruses and the cost of highly purified FVIII are the major factors that restrict prophylaxis in hemophilia therapy. One of the challenges created by the biotechnology revolution is the development of methods for the economical production of highly purified proteins in large scales. The present invention provides improved mammary expression cassettes useful for the expression of genes at high levels in the milk of transgenic animals. In particular, the present invention provides recombinant signal peptide sequences derived from a-lactalbumin and aS1-casein milk genes suitable for leading protein secretion in the mammary gland.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: February 23, 2010
    Assignee: National Chung Hsing University
    Inventors: Winston T. K. Cheng, Chuan-Mu Chen, Shwu-Wha Lin, Chih-Hong Wang, Chih-Jen Lin, Shinn-Chih Wu
  • Novel porcine pancreatic amylase gene promoter and transgenic pigs expressing heterologous digestive enzymes
    Publication number: 20070277253
    Abstract: The present invention relates to a novel promoter and its use in driving expression of foreign genes in transgenic animals (especially pigs). Accordingly, the present invention provides a method for producing transgenic animals harboring heterologous genes regulated by the promoter of the present invention.
    Type: Application
    Filed: May 23, 2006
    Publication date: November 29, 2007
    Inventors: Teng-Kuei Winston Cheng, Shinn-Chih Wu, Chi-Chen Hsu, Yu-Sheng Lin, Chih-Jen Lin
  • Expression vector for hirudin and transformed cells and transgenic animals containing said vector
    Publication number: 20070016969
    Abstract: The present invention relates to a nucleic acid construct encoding hirudin and a transgenic mammal whose genome comprises the nucleic acid construct as well as a process for producing hirudin from the transgenic mammal.
    Type: Application
    Filed: December 3, 2003
    Publication date: January 18, 2007
    Inventors: Ching-Fu Tu, Chi-Kai Yang, Chich-Sheng Lin, Chon-Ho Yen, I-Chung Chen, Shinn-Chih Wu, Yu-Ling Sun, Ming-Shing Liu, Ping-Cheng Yang
  • Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals
    Patent number: 7087808
    Abstract: The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: August 8, 2006
    Assignee: Animal Technology Institute Taiwan
    Inventors: Shinn Chih Wu, Teng Kuei Cheng, Chuan Mu Chen, Shau Ping Lin, Chon Ho Yen, Ping Cheng Yang
  • Method for producing biologically active human factor VIII in the milk of transgenic animals driven by mammary-specific expression cassettes
    Publication number: 20050229261
    Abstract: Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concentrates. The risk of transmitting blood-borne viruses and the cost of highly purified FVIII are the major factors that restrict prophylaxis in hemophilia therapy. One of the challenges created by the biotechnology revolution is the development of methods for the economical production of highly purified proteins in large scales. The present invention provides improved mammary expression cassettes useful for the expression of genes at high levels in the milk of transgenic animals. In particular, the present invention provides recombinant signal peptide sequences derived from a-lactalbumin and aS1-casein milk genes suitable for leading protein secretion in the mammary gland.
    Type: Application
    Filed: April 9, 2004
    Publication date: October 13, 2005
    Inventors: Winston Cheng, Chuan-Mu Chen, Shwu-Wha Lin, Chih-Hong Wang, Chih-Jen Lin, Shinn-Chih Wu
  • Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals
    Publication number: 20050114911
    Abstract: The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.
    Type: Application
    Filed: March 3, 2004
    Publication date: May 26, 2005
    Applicant: ANIMAL TECHNOLOGY INSTITUTE TAIWAN
    Inventors: Shinn-Chih Wu, Teng-Kuei Cheng, Chuan-Mu Chen, Shau-Ping Lin, Chon-Ho Yen, Ping-Cheng Yang