Abstract: Provided is a means capable of predicting a formation of thrombus or a risk thereof in a medical device performing blood circulation by a pump, by a simple and minimally invasive method. A method for predicting a formation of thrombus or a risk thereof in a medical device performing blood circulation by a pump, wherein it is predicted that thrombus is formed or there is a risk thereof in the medical device when a concentration or expression amount of ADAM28 in a body fluid sample collected from a subject wearing the medical device is elevated compared with a reference value.

Abstract: A removable pressure sensor assembly senses a pressure in an elastically deformable tube conveying blood in an extracorporeal circulator. The assembly includes a main body portion 31 and a pressure measurement element 40 disposed in main body portion 31. Main body portion 31 has a base portion 32 with a tube mounting recessed portion 34 such that an intermediate part of a tube 11 is removably fitted such that tube 11 is elastically deformed. Pressure measurement element 40 is exposed to tube 11 so that it measures a pressure of blood inside tube 11. A lid portion 33 holds tube 11 inside tube mounting recessed portion 34 by selectably closing recessed portion 34 of the base portion. Tube mounting recessed portion 34 has a rectangular cross section, and a width L of the rectangular cross section is set to be smaller than an external dimension D of tube 11.

Abstract: A centrifugal blood pump prevents a shaft member from oscillating due to expansion of a pump housing resulting from pressurization of the blood. The centrifugal blood pump is manufactured by assembling a bottom member 21 and a lid member 22, and compressing them in a direction in which the bottom member 21 and the lid member 22 approach each other by a deformation amount along their outer circumferential walls. The lid member and the bottom member are joined while in the compressed state in order to create a preloading force between the shaft member and bearings to resist the expansion due to pressurization of the blood during use.

Abstract: A removable pressure sensor assembly senses a pressure in an elastically deformable tube conveying blood in an extracorporeal circulator. The assembly includes a main body portion 31 and a pressure measurement element 40 disposed in main body portion 31. Main body portion 31 has a base portion 32with a tube mounting recessed portion 34 such that an intermediate part of a tube 11 is removably fitted such that tube 11 is elastically deformed. Pressure measurement element 40 is exposed to tube 11 so that it measures a pressure of blood inside tube 11. A lid portion 33 holds tube 11 inside tube mounting recessed portion 34 by selectably closing recessed portion 34 of the base portion. Tube mounting recessed portion 34 has a rectangular cross section, and a width L of the rectangular cross section is set to be smaller than an external dimension D of tube 11.

Abstract: A centrifugal blood pump prevents a shaft member from oscillating due to expansion of a pump housing resulting from pressurization of the blood. The centrifugal blood pump is manufactured by assembling a bottom member 21 and a lid member 22, and compressing them in a direction in which the bottom member 21 and the lid member 22 approach each other by a deformation amount along their outer circumferential walls. The lid member and the bottom member are joined while in the compressed state in order to create a preloading force between the shaft member and bearings to resist the expansion due to pressurization of the blood during use.