Abstract: The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 ?m, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.

Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 ?m, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.

Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.

Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.

Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.

Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.