Patents by Inventor Shinsaku FUSE

Shinsaku FUSE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210047595
    Abstract: The present invention provides a cell culture device characterized by comprising: a culture container; a rotating polymeric porous film housing part which is housed in the culture container, and has one or more culture medium inlet/outlet openings; and a polymeric porous film which is housed in the rotating polymeric porous film housing part, wherein the polymeric porous film is a modular polymeric porous film, and the rotating polymeric porous film housing part is rotated independently of the culture container.
    Type: Application
    Filed: January 24, 2019
    Publication date: February 18, 2021
    Inventors: Masahiko HAGIHARA, Takashi HARADA, Akihiro MATSUBAYASHI, Shinsaku FUSE
  • Publication number: 20210040430
    Abstract: Provided is a means that applies uniform culture conditions to a plurality of porous polymer membranes and makes it possible to stably culture a large quantity of cells. A cell culture module that comprises: a top part; a bottom part; a side part that has a culture solution in/outflow port; a plurality of partition parts that partition a space that is formed by the top part, the bottom part, and the side part and have a culture solution in/outflow port; and porous polymer membranes that are respectively fixed in at least two interstitial spaces selected from the interstitial space between the top part and the adjacent partition part, the interstitial space between the bottom part and the adjacent partition part, and the plurality of interstitial spaces between adjacent partition parts.
    Type: Application
    Filed: January 24, 2019
    Publication date: February 11, 2021
    Inventors: Masahiko HAGIHARA, Takashi HARADA, Akihiro MATSUBAYASHI, Shinsaku FUSE
  • Publication number: 20190330581
    Abstract: The present invention provides a cell cultivation module comprising a polymer porous film and a casing that has two or more culture medium inflow/outflow ports and accommodates the polymer porous film, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing.
    Type: Application
    Filed: July 25, 2017
    Publication date: October 31, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • Publication number: 20190276788
    Abstract: The present invention provides a cell cultivation device that is characterized by comprising: a polymer porous film; a cell cultivation part that has the polymer porous film; a shaft that passes through the cell cultivation part; and a cultivation tank in which at least one portion of the cell cultivation part is immersed, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, the cel
    Type: Application
    Filed: July 25, 2017
    Publication date: September 12, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • Publication number: 20190270956
    Abstract: Provided are a cell cultivation device comprising a polymer porous film, and a cell cultivation method using said cell cultivation device. The cell cultivation device comprises: two or more levels of parallel or antiparallel flat flow paths; a polymer porous film that is positioned in the flat flow paths; a culture medium supply means that is positioned at one end of the flat flow paths; a culture medium discharge means that is positioned at the other end of the flat flow paths; a head tank that is positioned at an upper section of the flat flow path of the uppermost level; a culture medium distribution means that distributes a culture broth from the head tank to the flat flow paths; and a culture medium recovery means that recovers the culture broth that is discharged from the culture medium discharge means.
    Type: Application
    Filed: July 25, 2017
    Publication date: September 5, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • Publication number: 20190264156
    Abstract: The present invention provides a cell cultivation device comprising a polymer porous film, and a cell cultivation method using said cell cultivation device. Provided is a cell cultivation device that has a siphon structure or a shishi-odoshi structure, said cell cultivation device comprising: a polymer porous film; a cell cultivation part that accommodates the polymer porous film; a liquid reservoir part that has the cell cultivation part stored in an interior thereof; a culture medium supply means that is positioned at an upper section of the liquid reservoir part; a culture medium discharge means that is positioned at a lower section of the liquid reservoir part; and a culture medium recovery means that recovers the culture medium that is collected in the liquid reservoir part and is intermittently expelled.
    Type: Application
    Filed: July 25, 2017
    Publication date: August 29, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE
  • Publication number: 20190264150
    Abstract: The present invention provides a cell cultivation method that includes: (1) a step in which a first culture medium including suspended cells is applied to a cell cultivation module; (2) a step in which a temperature at which cell cultivation is possible is maintained, and the cells are made to adsorb to the cell cultivation module; and (3) a step in which the cell cultivation module to which the cells are adsorbed is cultivated within a culture vessel with a second culture medium, wherein a polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that
    Type: Application
    Filed: July 25, 2017
    Publication date: August 29, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • Publication number: 20190241854
    Abstract: The present invention provides a cell cultivation device comprising: a polymer porous film; a cell cultivation part that accommodates the polymer porous film; a culture medium supply means that is positioned at an upper section of the cell cultivation part; and a culture medium recovery means that is positioned at a lower section of the cell cultivation part, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in commu
    Type: Application
    Filed: July 25, 2017
    Publication date: August 8, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA