Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; an actuator mechanism configured to position one or more heads proximate to one or more disk surfaces of the one or more disks; and one or more processing devices, comprising an actuator mechanism control system configured for controlling the actuator mechanism. The one or more processing devices are configured to: output a multi-rate excitation to at least one multi-rate notch filter of the actuator mechanism control system; detect a frequency response of the actuator mechanism in response to the multi-rate excitation; and calibrate the at least one multi-rate notch filter of the actuator mechanism control system, based at least in part on the detected frequency response of the actuator mechanism.

Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; an actuator mechanism configured to position one or more heads proximate to one or more disk surfaces of the one or more disks; and one or more processing devices, comprising an actuator mechanism control system configured for controlling the actuator mechanism. The one or more processing devices are configured to: output a multi-rate excitation to at least one multi-rate notch filter of the actuator mechanism control system; detect a frequency response of the actuator mechanism in response to the multi-rate excitation; and calibrate the at least one multi-rate notch filter of the actuator mechanism control system, based at least in part on the detected frequency response of the actuator mechanism.

Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; an actuator mechanism configured to position one or more heads proximate to one or more disk surfaces of the one or more disks; and one or more processing devices, comprising an actuator mechanism control system configured for controlling the actuator mechanism. The processing devices are configured to: apply coefficients for a multi-rate notch filter to a servo control loop; measure a multi-rate error rejection transfer function; determine whether a peak of the multi-rate error rejection transfer function is greater than a multi-rate error rejection transfer function threshold; and modify, responsively to determining that the peak of the multi-rate error rejection transfer function is not greater than the multi-rate error rejection transfer function threshold, the parameters of the multi-rate notch filter based at least in part on the peak of the multi-rate error rejection transfer function.

Abstract: The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50% or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 ?m, and a 90% cumulative particle diameter of 100 to 200 ?m.

Abstract: The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50% or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 ?m, and a 90% cumulative particle diameter of 100 to 200 ?m.

Abstract: The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50% or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 ?m, and a 90% cumulative particle diameter of 100 to 200 ?m.

Abstract: The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50% or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 ?m, and a 90% cumulative particle diameter of 100 to 200 ?m.

Abstract: A data storage device is disclosed comprising a head actuated over the disk. A first notch filter is calibrated at a first temperature, and a second notch filter is computed for a second temperature based on the first notch filter and a first delta temperature between the first temperature and the second temperature. The second notch filter is computed by transforming a continuous-time transfer function of the first notch filter adjusted by the first delta temperature into a discrete-time transfer function of the second notch filter.

Abstract: A magnetic head drive device including a suspension for supporting a magnetic head, and a main actuator that produces rotary movement of the magnetic head by applying current to a coil. The main actuator includes end arms each comprising a single micro-actuator, and an intermediate arm comprising two micro-actuators. The micro-actuators of the end arms are driven in the same direction, and the micro-actuators of the intermediate arm are driven in the opposite direction to the drive direction of the micro-actuators of said the arms.

Abstract: A flexible-printed-circuit (FPC) voice-coil assembly configured for integration in a voice-coil motor. The FPC voice-coil assembly includes at least one FPC voice coil. The FPC voice coil includes a coil including at least one coil turn, and a flexible substrate. The flexible substrate is coupled to the coil to form a flexible printed circuit. The FPC voice coil is configured for integration in a voice-coil motor. A voice-coil motor and a disk drive including the FPC voice-coil assembly are also provided.

Abstract: A flexible-printed-circuit (FPC) voice-coil assembly configured for integration in a voice-coil motor. The FPC voice-coil assembly includes at least one FPC voice coil. The FPC voice coil includes a coil including at least one coil turn, and a flexible substrate. The flexible substrate is coupled to the coil to form a flexible printed circuit. The FPC voice coil is configured for integration in a voice-coil motor. A voice-coil motor and a disk drive including the FPC voice-coil assembly are also provided.

Abstract: A magnetic head drive device including a suspension for supporting a magnetic head, and a main actuator that produces rotary movement of the magnetic head by applying current to a coil. The main actuator includes end arms each comprising a single micro-actuator, and an intermediate arm comprising two micro-actuators. The micro-actuators of the end arms are driven in the same direction, and the micro-actuators of the intermediate arm are driven in the opposite direction to the drive direction of the micro-actuators of said the arms.

Abstract: In a dual-stage actuator magnetic drive having a coarse actuator and a fine actuator, an amplitude level of a command signal for the fine actuator during a decoupling-path control depends on a gain of an applied fine actuator model. The fine actuator model gain depends on the amplitude level of the fine actuator command signal and needs to be calibrated to avoid performance degradation. The gain is calibrated by determining a deviation of the fine actuator model gain from the fine actuator gain during decoupling-path control. This deviation is obtained by comparing gain values of the open-loop transfer functions measured for the decoupling-path control case and the single coarse actuator control case with respect to the feedback loop of the coarse actuator at an excitation signal frequency, when the excitation signal is added to the coarse actuator.

Abstract: The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50 wt. % or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 ?m, and a 90% cumulative particle diameter of 100 to 200 ?m.

Abstract: It is intended to provide a screening system for a centrally acting drug transported across the blood-brain barrier, a drug acting on the blood-brain barrier itself, or a drug transferred into the brain without being expected to centrally act. Moreover, another object of the present invention is to achieve pathogenesis analysis study or the screening in a diseased state by applying various diseased environments to this screening system. The present invention provides an in-vitro model of blood-brain barrier obtained by using a three-dimensional culture apparatus comprising: a culture solution; a plate holding the culture solution; and a filter immersed in the culture solution and placed in no contact with the inside bottom of the plate, the filter having plural pores of 0.35 to 0.

Abstract: In a dual-stage actuator magnetic drive having a coarse actuator and a fine actuator, an amplitude level of a command signal for the fine actuator during a decoupling-path control depends on a gain of an applied fine actuator model. The fine actuator model gain depends on the amplitude level of the fine actuator command signal and needs to be calibrated to avoid performance degradation. The gain is calibrated by determining a deviation of the fine actuator model gain from the fine actuator gain during decoupling-path control. This deviation is obtained by comparing gain values of the open-loop transfer functions measured for the decoupling-path control case and the single coarse actuator control case with respect to the feedback loop of the coarse actuator at an excitation signal frequency, when the excitation signal is added to the coarse actuator.

Abstract: In a magnetic disk device, oscillation occurring at a frequency higher than Nyquist frequency is suppressed. In one embodiment, a multi-late filter having a resonance point at a frequency higher than the intended Nyquist frequency is introduced in a previous stage of a controlled object. At that time, since a resonance characteristic of the multi-rate filter is aliased by a sampler, the multi-rate filter is designed such that the resonance point after the aliasing is stabilized in phase by a following compensator.

Abstract: In one embodiment, a magnetic disk apparatus comprises a magnetic disk for recording information; a magnetic head that reads information from, or writes information to, the magnetic disk; an actuator device that drives the magnetic head; and a control system that controls the driving of the actuator device. The actuator device is configured by a dual stage actuator comprising a fine actuator that drives the head and a coarse actuator that drives the magnetic head together with the fine actuator. The control system includes a fine controller that generates an operational value for driving the fine actuator and a coarse controller that generates an operational amount for driving the coarse actuator. The control system includes a mechanism for smoothly changing the operational amount generated by the fine controller immediately before saturation resulting from an applied voltage limit of the fine actuator or at the time the fine actuator returns to a control range from the saturation.

Abstract: In a magnetic disk device, oscillation occurring at a frequency higher than Nyquist frequency is suppressed. In one embodiment, a multi-late filter having a resonance point at a frequency higher than the intended Nyquist frequency is introduced in a previous stage of a controlled object. At that time, since a resonance characteristic of the multi-rate filter is aliased by a sampler, the multi-rate filter is designed such that the resonance point after the aliasing is stabilized in phase by a following compensator.

Abstract: Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus, reduction or acceleration of the gastric emptying rate can be safely and conveniently examined. Namely, theses preparations are useful in objectively diagnosing the gastric motor function, as well as in evaluating and judging the drug effect or therapeutic effect of a drug concerning the gastric motor function on individual patients.