Patents by Inventor Shinsuke Sando
Shinsuke Sando has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220119440Abstract: A peptide having a fluoroalkyl group as its side chain and a method for producing, which comprises condensing a compound represented by the formula (6-2) or (6-4), where means that an asymmetric carbon atom has an absolute configuration of S or R, Rf is a C1-30 alkyl group which is substituted with at least two fluorine atoms, and which may further be substituted with a halogen atom other than a fluorine atom (when the C1-30 alkyl group is a C2-30 alkyl group, it may have 1 to 5 etheric oxygen atoms between carbon atoms), and R2 is a protecting group for the amino group, with a fluorinated amino acid having its carboxy group protected, an amino acid having its carboxy group protected, a fluorinated peptide having its C-terminal protected, or a peptide having its C-terminal protected.Type: ApplicationFiled: December 30, 2021Publication date: April 21, 2022Applicants: AGC Inc., THE UNIVERSITY OF TOKYOInventors: Takashi OKAZOE, Yuichiro ISHIBASHI, Shinsuke SANDO, Jumpei MORIMOTO, Kohsuke AIKAWA, Toshiki MIKAMI, Takahiro ONO
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Patent number: 10942191Abstract: There is provided a sensor and the like which can detect a first substance with high accuracy. A sensor for detecting whether an analyte contains a first substance, includes a base and a detection section including a second substance immobilized on a surface of the base. The second substance includes an amino acid, a bond which can be cleaved by a reaction with an enzyme, and a first compound which is bonded to the amino acid by the bond and includes a first group capable of bonding to other substances, and the analyte is configured to be introduced to the detection section by being contacted with a third substance which generates the enzyme by a reaction with the first substance.Type: GrantFiled: December 27, 2013Date of Patent: March 9, 2021Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KYOCERA CORPORATIONInventors: Hiroyasu Tanaka, Hideharu Kurioka, Shinsuke Sando
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Publication number: 20210063389Abstract: In an aspect, a sensor includes a combining portion 240 that combines with a second substance 220 having a molecular weight larger than a molecular weight of a first substance 210. Further, in an aspect, the sensor includes a substrate 10 including a surface on which the combining portion 240 is disposed, the combining portion 240 detecting whether or not the first substance 210 is included in an analyte that has come into contact with both an aptamer 230 including a first combining part 231 for the first substance 210 and a second combining part 232 for the second substance 220 and being combined with either of the first substance 210 and the second substance 220 and the second substance 220.Type: ApplicationFiled: October 9, 2020Publication date: March 4, 2021Inventors: Shinsuke SANDO, Hideharu KURIOKA
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Patent number: 10830768Abstract: In an aspect, a sensor includes a combining portion 240 that combines with a second substance 220 having a molecular weight larger than a molecular weight of a first substance 210. Further, in an aspect, the sensor includes a substrate 10 including a surface on which the combining portion 240 is disposed, the combining portion 240 detecting whether or not the first substance 210 is included in an analyte that has come into contact with both an aptamer 230 including a first combining part 231 for the first substance 210 and a second combining part 232 for the second substance 220 and being combined with either of the first substance 210 and the second substance 220 and the second substance 220.Type: GrantFiled: June 12, 2018Date of Patent: November 10, 2020Assignees: Kyushu University, National University Corporation, KYOCERA CorporationInventors: Shinsuke Sando, Hideharu Kurioka
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Patent number: 10731198Abstract: A sensor determines whether a specimen includes a first substance. In an exemplary embodiment, the sensor includes a base. In an exemplary embodiment, the sensor is configured to determine whether the specimen includes the first substance and further includes, on the base, a detection unit on which a second substance is immobilized. The second substance includes a bond that is cleft by the reaction with hydrogen peroxide. In an exemplary embodiment, the specimen that is brought in contact with an enzyme that generates the hydrogen peroxide by the reaction with the first substance is introduced to the detection unit in the sensor configured to determine whether the specimen includes the first substance.Type: GrantFiled: June 26, 2013Date of Patent: August 4, 2020Assignees: KYOCERA Corporation, Kyushu University, National University CorporationInventors: Hideharu Kurioka, Shinsuke Sando
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Patent number: 10619161Abstract: Provided is an aptamer including a polynucleotide of any of the following (a) to (c) and capable of binding to an HGF receptor to exhibit an activity of inhibiting the binding of HGF to the HGF receptor. (a) A polynucleotide consisting of a base sequence set forth in SEQ ID NO:1, (b) A polynucleotide consisting of a base sequence having the deletion, substitution, insertion and/or addition of one to several bases in the base sequence set forth in SEQ ID NO:1, and (c) A polynucleotide consisting of a base sequence having a sequence identity of 80% or more to the base sequence set forth in SEQ ID NO:1.Type: GrantFiled: September 9, 2015Date of Patent: April 14, 2020Assignee: THE UNIVERSITY OF TOKYOInventors: Shinsuke Sando, Ryosuke Ueki
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Patent number: 10398788Abstract: To provide a polymer having a high ratio of the amount thereof present in a tumor to the amount thereof present in blood (hereinafter, sometimes abbreviated as a tumor/blood ratio). The polymer has phosphorylcholine (derivative) as a side chain and has a dye (near-infrared dye) having absorption in the near-infrared wavelength region bound to the polymer.Type: GrantFiled: October 9, 2015Date of Patent: September 3, 2019Assignee: CANON KABUSHIKI KAISHAInventors: Teruyuki Kondo, Yasuhiro Aoyama, Hisatsugu Yamada, Yoshinori Hasegawa, Shinsuke Sando, Yu Kimura, Natsuki Matsumoto, Fumio Yamauchi, Tetsuya Yano, Masato Minami, Atsushi Takahashi, Kengo Kanazaki, Satoshi Ogawa
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Publication number: 20180313828Abstract: In an aspect, a sensor includes a combining portion 240 that combines with a second substance 220 having a molecular weight larger than a molecular weight of a first substance 210. Further, in an aspect, the sensor includes a substrate 10 including a surface on which the combining portion 240 is disposed, the combining portion 240 detecting whether or not the first substance 210 is included in an analyte that has come into contact with both an aptamer 230 including a first combining part 231 for the first substance 210 and a second combining part 232 for the second substance 220 and being combined with either of the first substance 210 and the second substance 220 and the second substance 220.Type: ApplicationFiled: June 12, 2018Publication date: November 1, 2018Inventors: Shinsuke SANDO, Hideharu KURIOKA
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Patent number: 10029021Abstract: As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of a 1H—13C—15N, 1H—15N—13C or 1H—13C—13C bond, that is, a structure labeled with stable isotopes of 13C and 15N, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.Type: GrantFiled: May 22, 2013Date of Patent: July 24, 2018Assignee: CANON KABUSHIKI KAISHAInventors: Teruyuki Kondo, Yasuhiro Aoyama, Hisatsugu Yamada, Yoshinori Hasegawa, Hidehito Tochio, Yu Kimura, Masahiro Shirakawa, Fuminori Sugihara, Tetsuya Matsuda, Shinsuke Sando, Masato Minami, Fumio Yamauchi, Tetsuya Yano, Hidetoshi Tsuzuki
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Patent number: 10012644Abstract: In an aspect, a sensor includes a combining portion that combines with a second substance having a molecular weight larger than a molecular weight of a first substance. Further, in an aspect, the sensor includes a substrate including a surface on which the combining portion is disposed. The combining portion detects whether or not the first substance is included in an analyte that has come into contact with both an aptamer and the second substance. The aptamer includes a first combining part for the first substance and a second combining part for the second substance and is combined with either of the first substance and the second substance.Type: GrantFiled: March 29, 2013Date of Patent: July 3, 2018Assignees: KYOCERA Corporation, Kyushu University, National University CorporationInventors: Shinsuke Sando, Hideharu Kurioka
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Publication number: 20170333575Abstract: To provide a polymer having a high ratio of the amount thereof present in a tumor to the amount thereof present in blood (hereinafter, sometimes abbreviated as a tumor/blood ratio). The polymer has phosphorylcholine (derivative) as a side chain and has a dye (near-infrared dye) having absorption in the near-infrared wavelength region bound to the polymer.Type: ApplicationFiled: October 9, 2015Publication date: November 23, 2017Inventors: Teruyuki Kondo, Yasuhiro Aoyama, Hisatsugu Yamada, Yoshinori Hasegawa, Shinsuke Sando, Yu Kimura, Natsuki Matsumoto, Fumio Yamauchi, Tetsuya Yano, Masato Minami, Atsushi Takahashi, Kengo Kanazaki, Satoshi Ogawa
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Publication number: 20170275630Abstract: Provided is an aptamer including a polynucleotide of any of the following (a) to (c) and capable of binding to an HGF receptor to exhibit an activity of inhibiting the binding of HGF to the HGF receptor. (a) A polynucleotide consisting of a base sequence set forth in SEQ ID NO: 1, (b) A polynucleotide consisting of a base sequence having the deletion, substitution, insertion and/or addition of one to several bases in the base sequence set forth in SEQ ID NO: 1, and (c) A polynucleotide consisting of a base sequence having a sequence identity of 80% or more to the base sequence set forth in SEQ ID NO: 1.Type: ApplicationFiled: September 9, 2015Publication date: September 28, 2017Applicant: The University of TokyoInventors: Shinsuke Sando, Ryosuke Ueki
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Publication number: 20160187358Abstract: There is provided a sensor and the like which can detect a first substance with high accuracy. A sensor for detecting whether an analyte contains a first substance, includes a base and a detection section including a second substance immobilized on a surface of the base. The second substance includes an amino acid, a bond which can be cleaved by a reaction with an enzyme, and a first compound which is bonded to the amino acid by the bond and includes a first group capable of bonding to other substances, and the analyte is configured to be introduced to the detection section by being contacted with a third substance which generates the enzyme by a reaction with the first substance.Type: ApplicationFiled: December 27, 2013Publication date: June 30, 2016Inventors: Hiroyasu TANAKA, Hideharu KURIOKA, Shinsuke SANDO
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Publication number: 20150232912Abstract: A sensor determines whether a specimen includes a first substance. In an exemplary embodiment, the sensor includes a base. In an exemplary embodiment, the sensor is configured to determine whether the specimen includes the first substance and further includes, on the base, a detection unit on which a second substance is immobilized. The second substance includes a bond that is cleft by the reaction with hydrogen peroxide. In an exemplary embodiment, the specimen that is brought in contact with an enzyme that generates the hydrogen peroxide by the reaction with the first substance is introduced to the detection unit in the sensor configured to determine whether the specimen includes the first substance.Type: ApplicationFiled: June 26, 2012Publication date: August 20, 2015Inventors: Hideharu Kurioka, Shinsuke Sando
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Patent number: 8980543Abstract: An object of the present invention is to provide a substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.Type: GrantFiled: May 31, 2013Date of Patent: March 17, 2015Assignee: Canon Kabushiki KaishaInventors: Fumio Yamauchi, Kimihiro Yoshimura, Katsuaki Kuge, Tetsuya Yano, Masahiro Shirakawa, Yasuhiro Aoyama, Shinsuke Sando
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Publication number: 20150071861Abstract: As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of a 1H—13C—15N, 1H—15N—13C or 1H—13C—13C bond, that is, a structure labeled with stable isotopes of 13C and 15N, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.Type: ApplicationFiled: May 22, 2013Publication date: March 12, 2015Applicant: CANON KABUSHIKI KAISHAInventors: Teruyuki Kondo, Yasuhiro Aoyama, Hisatsugu Yamada, Yoshinori Hasegawa, Hidehito Tochio, Yu Kimura, Masahiro Shirakawa, Fuminori Sugihara, Tetsuya Matsuda, Shinsuke Sando, Masato Minami, Fumio Yamauchi, Tetsuya Yano, Hidetoshi Tsuzuki
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Publication number: 20150065394Abstract: In an aspect, a sensor includes a combining portion that combines with a second substance having a molecular weight larger than a molecular weight of a first substance. Further, in an aspect, the sensor includes a substrate including a surface on which the combining portion is disposed. The combining portion detects whether or not the first substance is included in an analyte that has come into contact with both an aptamer and the second substance. The aptamer includes a first combining part for the first substance and a second combining part for the second substance and is combined with either of the first substance and the second substance.Type: ApplicationFiled: March 29, 2013Publication date: March 5, 2015Inventors: Shinsuke Sando, Hideharu Kurioka
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Publication number: 20130288345Abstract: An object of the present invention is to provide a substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.Type: ApplicationFiled: May 31, 2013Publication date: October 31, 2013Inventors: Fumio Yamauchi, Kimihiro Yoshimura, Katsuaki Kuge, Tetsuya Yano, Masahiro Shirakawa, Yasuhiro Aoyama, Shinsuke Sando
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Patent number: 8481254Abstract: Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.Type: GrantFiled: September 8, 2008Date of Patent: July 9, 2013Assignee: Canon Kabushiki KaishaInventors: Fumio Yamauchi, Kimihiro Yoshimura, Katsuaki Kuge, Tetsuya Yano, Masahiro Shirakawa, Yasuhiro Aoyama, Shinsuke Sando
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Publication number: 20100248279Abstract: Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.Type: ApplicationFiled: September 8, 2008Publication date: September 30, 2010Applicants: KYOTO UNIVERSITY, CANON KABUSHIKI KAISHAInventors: Fumio Yamauchi, Kimihiro Yoshimura, Katsuaki Kuge, Tetsuya Yano, Masahiro Shirakawa, Yasuhiro Aoyama, Shinsuke Sando