Patents by Inventor Shinsuke Uno
Shinsuke Uno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170321090Abstract: To prevent an ink from discoloring and an ink from remaining when a tape for label writer using a transparent synthetic resin film which is colorized by an ink layer is peeled off from an adherend. A tape for label writer being composed of: (i) the tape for label writer having a layer structure including at least a process layer, substrate layer, ink layer, barrier layer, and adhesive layer in this order; (ii) the substrate layer being a synthetic resin film; and (iii) the ink layer including one adhesive resin selected from the group including polyurethane resin, acrylic resin and polyester resin, and a pigment.Type: ApplicationFiled: November 11, 2015Publication date: November 9, 2017Inventors: Jugaku SUGAI, Takao HIKITA, Shinsuke UNO
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Patent number: 8759025Abstract: The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.Type: GrantFiled: December 19, 2011Date of Patent: June 24, 2014Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yasufumi Kikuchi, Shinsuke Uno, Yasuko Kinoshita, Shigeyuki Iijima, Naoshi Fukushima, Masayuki Tsuchiya
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Publication number: 20130295096Abstract: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist.Type: ApplicationFiled: April 3, 2013Publication date: November 7, 2013Inventors: Naoshi Fukushima, Masayuki Tsuchiya, Shinsuke Uno, Toshihiko Ohtomo, Naohiro Yabuta, Hiroyuki Tsunoda
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Publication number: 20120156724Abstract: The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.Type: ApplicationFiled: December 19, 2011Publication date: June 21, 2012Inventors: Yasufumi Kikuchi, Shinsuke Uno, Yasuko Kinoshita, Shigeyuki Iijima, Naoshi Fukushima, Masayuki Tsuchiya
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Patent number: 8101719Abstract: The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.Type: GrantFiled: November 11, 2004Date of Patent: January 24, 2012Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yasufumi Kikuchi, Shinsuke Uno, Yasuka Kinoshita, Shigeyuki Iijima, Naoshi Fukushima, Masayuki Tsuchiya
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Patent number: 7696325Abstract: This invention relates to reconstructed polypeptides which have properties of inducing apoptosis of nucleated blood cells having Integrin Associated Protein (IAP) and causing no hemagglutination. The reconstructed polypeptides comprise two or more H chain V regions and two or more L chain V regions of a monoclonal antibody which induces apoptosis of nucleated blood cells having IAP. The reconstructed polypeptides are useful as a therapeutic agent for blood dyscrasia such as leukemia.Type: GrantFiled: March 12, 2001Date of Patent: April 13, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Naoshi Fukushima, Masayuki Tsuchiya, Masayoshi Oh-Eda, Shinsuke Uno, Yasufumi Kikuchi
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Publication number: 20090311718Abstract: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases.Type: ApplicationFiled: July 2, 2009Publication date: December 17, 2009Inventors: Naoshi Fukushima, Masayuki Tsuchiya, Shinsuke Uno, Toshihiko Ohtomo, Naohiro Yabuta, Hiroyuki Tsunod
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Patent number: 7531643Abstract: The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, and the antigens that induce apoptosis of nucleated blood cells having human Integrin Associated Protein. Accordingly, they are useful as antibodies that recognize human Integrin Associated Protein for its distinction and identification, while also having an action of inducing apoptosis of nucleated blood cells; these properties can be utilized to prepare useful therapeutic agents in the field of treatment for myeloid leukemia and lymphoid leukemia.Type: GrantFiled: January 31, 2003Date of Patent: May 12, 2009Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Naoshi Fukushima, Shinsuke Uno
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Publication number: 20080107654Abstract: The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.Type: ApplicationFiled: November 11, 2004Publication date: May 8, 2008Inventors: Yasufumi Kikuchi, Shinsuke Uno, Yasuko Kinoshita, Shigeyuki Iijima, Naoshi Fukushima, Masayuki Tsuchiya
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Publication number: 20040258684Abstract: Modified antibodies containing 2 or more H chain V domains and or more L chain V domains of a monoclonal antibody which can transduce a signal into cells by crosslinking a cell surface molecule, thereby serving as an agonist. Because of being usable as agonists for signal transduction, these modified antibodies are useful as, for example, preventives and/or remedies for various diseases such as cancer, inflammation, hormone disorders and blood diseases.Type: ApplicationFiled: October 7, 2002Publication date: December 23, 2004Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Naoshi Fukushima, Masayuki Tsuchiya, Masayoshi Oh-eda, Shinsuke Uno, Yasufumi Kikuchi, Toshihiko Ohtomo
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Publication number: 20040242847Abstract: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases.Type: ApplicationFiled: April 18, 2003Publication date: December 2, 2004Inventors: Naoshi Fukushima, Masayuki Tscuchiya, Shinsuke Uno, Toshihiko Ohtomo, Naohiro Yabuta, Hiroyuki Tsunoda
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Publication number: 20040073013Abstract: This invention relates to reconstructed polypeptides which have properties of inducing apoptosis of nucleated blood cells having Integrin Associated Protein (IAP) and causing no hemagglutination. The reconstructed polypeptides comprise two or more H chain V regions and two or more L chain V regions of a monoclonal antibody which induces apoptosis of nucleated blood cells having IAP. The reconstructed polypeptides are useful as a therapeutic agent for blood dyscrasia such as leukemia.Type: ApplicationFiled: October 2, 2002Publication date: April 15, 2004Inventors: Naoshi Fukushima, Masayuki Tsuchiya, Masayoshi Oh-Eda, Shinsuke Uno, Yasufumi Kikuchi
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Publication number: 20040058393Abstract: Modified antibodies containing 2 or more H chain V domains and or more L chain V domains of a monoclonal antibody which can transduce a signal into cells by crosslinking a cell surface molecule, thereby serving as an agonist. Because of being usable as agonists for signal transduction, these modified antibodies are useful as, for example, preventives and/or remedies for various diseases such as cancer, inflammation, hormone disorders and blood diseases.Type: ApplicationFiled: June 24, 2003Publication date: March 25, 2004Inventors: Naoshi Fukishima, Masayuki Tsuchiya, Masayoshi Oheda, Shinsuke Uno, Yasufumi Kikuchi, Toshihiko Ohtomo
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Publication number: 20030211108Abstract: The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, and the antigens that induce apoptosis of nucleated blood cells having human Integrin Associated Protein. Accordingly, they are useful as antibodies that recognize human Integrin Associated Protein for its distinction and identification, while also having an action of inducing apoptosis of nucleated blood cells; these properties can be utilized to prepare useful therapeutic agents in the field of treatment for myeloid leukemia and lymphoid leukemia.Type: ApplicationFiled: January 31, 2003Publication date: November 13, 2003Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Naoshi Fukushima, Shinsuke Uno
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Publication number: 20030157100Abstract: The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, and the antigens that induce apoptosis of nucleated blood cells having human Integrin Associated Protein. Accordingly, they are useful as antibodies that recognize human Integrin Associated Protein for its distinction and identification, while also having an action of inducing apoptosis of nucleated blood cells; these properties can be utilized to prepare useful therapeutic agents in the field of treatment for myeloid leukemia and lymphoid leukemia.Type: ApplicationFiled: March 10, 2003Publication date: August 21, 2003Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Naoshi Fukushima, Shinsuke Uno
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Publication number: 20030108546Abstract: This invention relates to Novel single-chain Fvs capable of inducing apoptosis of nucleated blood cells having Integrin Associated Protein (IAP). The single-chain Fvs of the invention comprise an L chain comprising the L chain V region of the mouse monoclonal antibodies capable of inducing apoptosis of cells having human IAP, an H chain comprising the H chain V region of the mouse monoclonal antibodies capable of inducing apoptosis of cells having human IAP and a linker connecting them. The single-chain Fvs of the invention are useful as a therapeutic agent for blood dyscrasia such as leukemia.Type: ApplicationFiled: May 6, 2002Publication date: June 12, 2003Applicant: Chugai Seiyaku kabushiki kaishaInventors: Naoshi Fukushima, Shinsuke Uno, Masayoshi Oh-Eda, Yasufumi Kikuchi