Patents by Inventor Shintaro Hirashima

Shintaro Hirashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLE COMPOUNDS SUBSTITUTED WITH HETEROARYL AND PHARMACEUTICAL USE THEREOF
    Publication number: 20220048896
    Abstract: Pyrazole compounds substituted with heteroaryl or pharmaceutically acceptable salts thereof that have an SGLT1 inhibitory activity and are useful for a drug, pharmaceutical compositions comprising the same, and pharmaceutical use thereof are disclosed. Specifically, a compound of Formula [X]: wherein R1 is hydrogen or halogen, R2 is C1-6 alkyl or halo-C1-6 alkyl, Ring Het is substituted pyridyl or optionally substituted pyrazinyl, pyrimidinyl, or pyridazinyl, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising it, and pharmaceutical use thereof is provided.
    Type: Application
    Filed: March 25, 2021
    Publication date: February 17, 2022
    Inventors: Tomoya MIURA, Shintaro HIRASHIMA, Tomoyuki MANABE, Tetsuya IIDA, Kentaro SAKURAI
  • Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
    Patent number: 10988462
    Abstract: Pyrazole compounds substituted with heteroaryl or pharmaceutically acceptable salts thereof that have an SGLT1 inhibitory activity and are useful for a drug, pharmaceutical compositions comprising the same, and pharmaceutical use thereof are disclosed. Specifically, a compound of Formula [X]: wherein R1 is hydrogen or halogen, R2 is C1-6 alkyl or halo-C1-6 alkyl, Ring Het is substituted pyridyl or optionally substituted pyrazinyl, pyrimidinyl, or pyridazinyl, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising it, and pharmaceutical use thereof is provided.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: April 27, 2021
    Assignee: Japan Tobacco Inc.
    Inventors: Tomoya Miura, Shintaro Hirashima, Tomoyuki Manabe, Tetsuya Iida, Kentaro Sakurai
  • PYRAZOLE COMPOUNDS SUBSTITUTED WITH HETEROARYL AND PHARMACEUTICAL USE THEREOF
    Publication number: 20190330193
    Abstract: Pyrazole compounds substituted with heteroaryl or pharmaceutically acceptable salts thereof that have an SGLT1 inhibitory activity and are useful for a drug, pharmaceutical compositions comprising the same, and pharmaceutical use thereof are disclosed. Specifically, a compound of Formula [X]: wherein R1 is hydrogen or halogen, R2 is C1-6 alkyl or halo-C1-6 alkyl, Ring Het is substituted pyridyl or optionally substituted pyrazinyl, pyrimidinyl, or pyridazinyl, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising it, and pharmaceutical use thereof is provided.
    Type: Application
    Filed: April 3, 2019
    Publication date: October 31, 2019
    Inventors: Tomoya MIURA, Shintaro HIRASHIMA, Tomoyuki MANABE, Tetsuya IIDA, Kentaro SAKURAI
  • AMIDE COMPOUND AND MEDICINAL USE THEREOF
    Publication number: 20160346256
    Abstract: A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 28, 2015
    Publication date: December 1, 2016
    Applicant: Japan Tobacco Inc.
    Inventors: Takaki Maeba, Katsuya Maeda, Masayuki Kotoku, Kazuyuki Hirata, Noriyoshi Seki, Hiroshi Yamanaka, Takayuki Sakai, Shintaro Hirashima, Shingo Obika, Makoto Shiozaki, Masahiro Yokota
  • TRIAZOLE-ISOXAZOLE COMPOUND AND MEDICAL USE THEREOF
    Publication number: 20160137639
    Abstract: A compound represented by Formula [I]: or pharmaceutically acceptable salt thereof, wherein each symbol is as defined in the description.
    Type: Application
    Filed: October 25, 2013
    Publication date: May 19, 2016
    Inventors: Masayuki KOTOKU, Takaki MAEBA, Noriyoshi SEKI, Shintaro HIRASHIMA, Shingo FUJIOKA, Shingo OBIKA, Hiroshi YAMANAKA, Masahiro YOKOTA, Takayuki SAKAI, Kazuyuki HIRATA, Katsuya MAEDA, Makoto SHIOZAKI, Yuko SHINAGAWA, Taku IKENOGAMI, Satoki DOI, Takahiro OKA, Takuya MATSUO, Yoshihiro SUWA, Keisuke ITO, Satoru NOJI, Yoshinori HARA
  • AMIDE COMPOUND AND MEDICINAL USE THEREOF
    Publication number: 20140296306
    Abstract: A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 30, 2013
    Publication date: October 2, 2014
    Applicant: Japan Tobacco Inc.
    Inventors: Takaki Maeba, Katsuya Maeda, Masayuki Kotoku, Kazuyuki Hirata, Noriyoshi Seki, Hiroshi Yamanaka, Takayuki Sakai, Shintaro Hirashima, Shingo Obika, Makoto Shiozaki, Masahiro Yokota
  • Amide compound and medicinal use thereof
    Patent number: 8604069
    Abstract: A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: December 10, 2013
    Assignee: Japan Tobacco Inc.
    Inventors: Takaki Maeba, Katsuya Maeda, Masayuki Kotoku, Kazayuki Hirata, Noriyoshi Seki, Hiroshi Yamanaka, Takayuki Sakai, Shintaro Hirashima, Shingo Obika, Makoto Shiozaki, Masahiro Yokota
  • AMIDE COMPOUND AND MEDICINAL USE THEREOF
    Publication number: 20120322837
    Abstract: A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 27, 2012
    Publication date: December 20, 2012
    Applicant: JAPAN TOBACCO INC.
    Inventors: Takaki Maeba, Katsuya Maeda, Masayuki Kotoku, Kazuyuki Hirata, Noriyoshi Seki, Hiroshi Yamanaka, Takayuki Sakai, Shintaro Hirashima, Shingo Obika, Makoto Shiozaki, Masahiro Yokota
  • TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR
    Publication number: 20120070409
    Abstract: The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Application
    Filed: February 3, 2011
    Publication date: March 22, 2012
    Applicant: Japan Tobacco Inc.
    Inventors: Takahiro Oka, Kazutaka Ikegashira, Shintaro Hirashima, Hiroshi Yamanaka, Satoru Noji, Yasushi Niwa, Yoko Matsumoto, Toshihiro Sato, Izuru Ando, Yukihiro Nomura
  • 5-5-MEMBERED FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR
    Publication number: 20120020920
    Abstract: The present invention relates to a fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Application
    Filed: February 24, 2011
    Publication date: January 26, 2012
    Applicant: Japan Tobacco Inc.
    Inventors: Ryo Mizojiri, Shintaro Hirashima, Takahiro Oka, Kenta Aoki, Satoru Noji, Izuru Ando, Toshihiro Sato, Yasushi Niwa
  • Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
    Patent number: 7977331
    Abstract: The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: July 12, 2011
    Assignee: Japan Tobacco Inc.
    Inventors: Takahiro Oka, Kazutaka Ikegashira, Shintaro Hirashima, Hiroshi Yamanaka, Satoru Noji, Yasushi Niwa, Yoko Matsumoto, Toshihiro Sato, Izuru Ando, Yukihiro Nomura
  • 5-5-Membered fused heterocyclic compound and use thereof as HCV polymerase inhibitor
    Publication number: 20090036444
    Abstract: The present invention relates to a fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Application
    Filed: May 18, 2006
    Publication date: February 5, 2009
    Applicant: Japan Tobacco Inc.
    Inventors: Ryo Mizojiri, Shintaro Hirashima, Takahiro Oka, Kenta Aoki, Satoru Noji, Izuru Ando, Toshihiro Sato, Yasushi Niwa
  • Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
    Publication number: 20070049593
    Abstract: The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Application
    Filed: February 23, 2005
    Publication date: March 1, 2007
    Applicant: Japan Tobacco Inc.
    Inventors: Takahiro Oka, Kazutaka Ikegashira, Shintaro Hirashima, Hiroshi Yamanaka, Satoru Noji, Yasushi Niwa, Yoko Matsumoto, Toshihiro Sato, Izuru Ando, Yukihiro Nomura