Patents by Inventor Shintaro Hosoe
Shintaro Hosoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11949111Abstract: In a lithium ion secondary battery (1), a positive electrode (2) and a negative electrode (3) are alternately adjacent to each other via separators (4) and (5). The positive electrode (2) includes a positive electrode current collector composed of a metal porous body, a first positive electrode active material (21) held on one side of the positive electrode current collector, and a second positive electrode active material (22) held on the other side. The negative electrode (3) includes a negative electrode current collector composed of a metal porous body, a first negative electrode active material (31) held on one side of the negative electrode current collector, and a second negative electrode active material (32) held on the other side. The first positive electrode active material (21) faces the first negative electrode active material (31), and the positive electrode active material (22) faces the second negative electrode active material (32).Type: GrantFiled: May 9, 2019Date of Patent: April 2, 2024Assignees: HONDA MOTOR CO., LTD., SUMITOMO ELECTRIC INDUSTRIES, LTD.Inventors: Kiyoshi Tanaami, Akihisa Tanaka, Shintaro Aoyagi, Kazuki Okuno, Akihisa Hosoe, Kikuo Senoo, Hiroshi Takebayashi
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Patent number: 11633365Abstract: The present invention provides a nucleic acid-containing lipid nanoparticle comprising an analog of a fatty acid ester of glycerol, and a nucleic acid, wherein the analog is not hydrolyzable by a lipase.Type: GrantFiled: August 6, 2018Date of Patent: April 25, 2023Assignee: KYOWA KIRIN CO., LTD.Inventors: Kentaro Hatanaka, Michihiro Maemoto, Shintaro Hosoe
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Patent number: 11471533Abstract: The present invention provides a compound represented by formula (I) usable as a cationic lipid that facilitates introduction of a nucleic acid, for example, into a cell, and a composition or the like containing the compound.Type: GrantFiled: September 27, 2017Date of Patent: October 18, 2022Assignee: KYOWA KIRIN CO., LTD.Inventors: Shintaro Hosoe, Hayato Yabuuchi
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Patent number: 11298326Abstract: The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.Type: GrantFiled: March 24, 2016Date of Patent: April 12, 2022Assignee: KYOWA KIRIN CO., LTD.Inventors: Kentaro Hatanaka, Nobuhiro Yagi, Takeshi Kuboyama, Kaori Yagi, Shintaro Hosoe
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Publication number: 20210275672Abstract: The present invention provides a compound represented by formula (I) usable as a cationic lipid that facilitates introduction of a nucleic acid, for example, into a cell, and a composition or the like containing the compound.Type: ApplicationFiled: September 27, 2017Publication date: September 9, 2021Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Shintaro HOSOE, Hayato YABUUCHI
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Publication number: 20200368173Abstract: The present invention provides a nucleic acid-containing lipid nanoparticle comprising an analog of a fatty acid ester of glycerol, and a nucleic acid, wherein the analog is not hydrolyzable by a lipase.Type: ApplicationFiled: August 6, 2018Publication date: November 26, 2020Applicant: KYOWA KIRIN CO., LTD.Inventors: Kentaro HATANAKA, Michihiro MAEMOTO, Shintaro HOSOE
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Patent number: 10525138Abstract: The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as a cationic lipid, and the like.Type: GrantFiled: December 26, 2016Date of Patent: January 7, 2020Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Shintaro Hosoe, Tomoyuki Naoi
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Patent number: 10500158Abstract: The present invention provides a cationic lipid represented by the formula (I) wherein R1 and R2 each represents alkyl having 8 to 24 carbon atoms or the like; R3 represents a hydrogen atom, alkyl having 1 to 3 carbon atoms, the formula (A) wherein R4 and R5 each represents a hydrogen atom or the like, and n3 represents an integer from 2 to 6, or the formula (B) wherein R6 and R7 each represents a hydrogen atom or the like, and n4 represents an integer from 1 to 6; n1 represents an integer from 0 to 4; and n2 represents an integer from 1 to 4, provided that the case where n1 is 0 and n2 is 1 is excluded, and a composition which contains the cationic lipid and a nucleic acid, or the like.Type: GrantFiled: June 30, 2015Date of Patent: December 10, 2019Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Shintaro Hosoe, Tomoyuki Naoi
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Patent number: 10342758Abstract: Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein R1 is alkenyl or the like, R2 is alkenyl or the like, R3 and R4 are each alkyl, or are combined together to form alkylene, or R3 and R5 are combined together to form alkylene, R5 is a hydrogen atom or the like, or is combined together with R3 to form alkylene, X1 is alkylene, and X2 is a single bond or alkylene).Type: GrantFiled: July 8, 2013Date of Patent: July 9, 2019Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi, Kaori Yagi, Shintaro Hosoe
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Publication number: 20190008975Abstract: The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as a cationic lipid, and the like.Type: ApplicationFiled: December 26, 2016Publication date: January 10, 2019Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Shintaro HOSOE, Tomoyuki NAOI
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Publication number: 20180353434Abstract: The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.Type: ApplicationFiled: March 24, 2016Publication date: December 13, 2018Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Kentaro HATANAKA, Nobuhiro YAGI, Takeshi KUBOYAMA, Kaori YAGI, Shintaro HOSOE
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Publication number: 20180193471Abstract: The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target ?2GPI mRNA sequence, and the 3? end or 5? end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).Type: ApplicationFiled: July 15, 2016Publication date: July 12, 2018Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Kazutaka NAGATOMO, Kazuhiro MASUDA, Minako KANDA, Yoji YAMADA, Hiroto IWAI, Asana MAKINO, Shintaro HOSOE, Takeshi KUBOYAMA, Keiji UEHARA, Yasuhiro SUZUKI
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Publication number: 20170224619Abstract: The present invention provides a cationic lipid represented by the formula (I) wherein R1 and R2 each represents alkyl having 8 to 24 carbon atoms or the like; R3 represents a hydrogen atom, alkyl having 1 to 3 carbon atoms, the formula (A) wherein R4 and R5 each represents a hydrogen atom or the like, and n3 represents an integer from 2 to 6, or the formula (B) wherein R6 and R7 each represents a hydrogen atom or the like, and n4 represents an integer from 1 to 6; n1 represents an integer from 0 to 4; and n2 represents an integer from 1 to 4, provided that the case where n1 is 0 and n2 is 1 is excluded, and a composition which contains the cationic lipid and a nucleic acid, or the like.Type: ApplicationFiled: June 30, 2015Publication date: August 10, 2017Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Shintaro HOSOE, Tomoyuki NAOI
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Publication number: 20150174261Abstract: Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein R1 is alkenyl or the like, R2 is alkenyl or the like, R3 and R4 are each alkyl, or are combined together to form alkylene, or R3 and R5 are combined together to form alkylene, R5 is a hydrogen atom or the like, or is combined together with R3 to form alkylene, X1 is alkylene, and X2 is a single bond or alkylene).Type: ApplicationFiled: July 8, 2013Publication date: June 25, 2015Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi, Kaori Yagi, Shintaro Hosoe
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Patent number: 8969345Abstract: A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPAR? agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.Type: GrantFiled: August 3, 2012Date of Patent: March 3, 2015Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Keisuke Yamamoto, Tomohiro Tamura, Rina Nakamura, Kimihisa Ueno, Shintaro Hosoe
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Publication number: 20140163008Abstract: A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPAR? agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.Type: ApplicationFiled: August 3, 2011Publication date: June 12, 2014Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Keisuke Yamamoto, Tomohiro Tamura, Rina Nakamura, Kimihisa Ueno, Shintaro Hosoe