Abstract: A clip device for gripping biological tissue of a patient includes a clip having a first arm and second arm closeable by operation of a wire that is reciprocally moveable in a longitudinal channel of a sheath; and a bendable member at a distal end region of the sheath. The bendable member can be an integral portion of the sheath or a separate structure. The bendable member is configured to allow a distal end of a clip to rotate or swing toward a proximal end region of the sheath of the device, which orients the clip relative to the sheath to facilitate grasping of tissue even when the approach of the clip is tangential to the tissue, e.g., at an angle (?) less than 90. The bendable member can be configured to allow a distal end of a clip to rotate or swing toward a proximal end region of a sheath and form an angle of up to at least about 45 degrees, such up to about 60 degrees or up to about 90 degrees, or higher.

Abstract: The ligation device includes a clip unit, an applicator, and the applicator includes a sheath, an operation wire, a second link that is provided on the operation wire, and is capable of being fitted to the first link at a protrusion position, the second link configured to be restricted a releasing of fitting to the first link at an accommodation position, a slider connected to the operation wire and is configured to move with a first operation, and a limiter including a switch member configured to move in an intersecting direction that intersects a direction of the first operation with a second operation. The limiter is configured to limit a movement range of the slider when the second operation is not performed, and configured to release a limitation of the movement range of the slider with the second operation and to allow the second link to move toward the protrusion position.

Abstract: A clip device for gripping biological tissue of a patient includes a clip having a first arm and second arm closeable by operation of a wire that is reciprocally moveable in a longitudinal channel of a sheath; and a bendable member at a distal end region of the sheath. The bendable member can be an integral portion of the sheath or a separate structure. The bendable member is configured to allow a distal end of a clip to rotate or swing toward a proximal end region of the sheath of the device, which orients the clip relative to the sheath to facilitate grasping of tissue even when the approach of the clip is tangential to the tissue, e.g., at an angle (?) less than 90. The bendable member can be configured to allow a distal end of a clip to rotate or swing toward a proximal end region of a sheath and form an angle of up to at least about 45 degrees, such up to about 60 degrees or up to about 90 degrees, or higher.

Abstract: Treatment device with clip is reciprocally closed and opened in one operation and locked in a second, distinct operation. The clip has a first arm and second arm which are configured to move in a direction toward and away from each other to close and open the clip; a wire connected to a proximal end of the clip configured to reciprocally move within a sheath to close and open the clip; and one or more latch elements on the clip configured to lock the clip in a closed state. Operating the wire does not lock the clip in a closed state in a single operation. Rather, the clip can be locked by another operation that is distinct from operating the wire for reciprocal movement, such as operating a stopper, an inner sheath reciprocally movable to slid over the clip arms, or a locking ring slidable over the clip arms.

Abstract: A clip device includes a sheath having a lumen with at least one open end and a plurality of clip arms movable between a first configuration in which the plurality of clip arms are opened to receive a target tissue, and a second configuration in which the plurality of clip arms are closed to grip the target tissue. Locking mechanisms respectively provided on the plurality of clip arms engage one another for maintaining the second configuration. A restraining mechanism is optionally configured to be associated with the locking mechanisms to prevent the target tissue from being pinched between the locking mechanisms.

Abstract: A ligation device includes a first arm, a second arm, a holding tube, an operation wire, a sheath, and a link mechanism having a first link and a second link which are connected to each other and engage the holding tube with the sheath, wherein the link mechanism is configured to be switch between a disengaged configuration in which engagement between the holding tube and the sheath is released and an engaged configuration in which the holding tube is engaged with the sheath due to the operation wire.

Abstract: A clip for gripping tissue can having a first arm with a first claw at a distal end of the first arm, and second arm, with a second claw at a distal end of the second arm, in which the first arm and second arm are configured to move in a direction toward each other to close the clip. The clips include one or more anchors on the arms of the clip which protrude in a direction other than the direction that the first arm and second arm are configured to move toward each other to close the clip. Such anchors can more readily attach to tissue of a patient upon contact than clips without an anchor.

Abstract: A clip device for gripping biological tissue of a patient includes a clip having a first arm and second arm closeable by operation of a wire that is reciprocally moveable in a longitudinal channel of a sheath; and a bendable member at a distal end region of the sheath. The bendable member can be an integral portion of the sheath or a separate structure. The bendable member is configured to allow a distal end of a clip to rotate or swing toward a proximal end region of the sheath of the device, which orients the clip relative to the sheath to facilitate grasping of tissue even when the approach of the clip is tangential to the tissue, e.g., at an angle (?) less than 90. The bendable member can be configured to allow a distal end of a clip to rotate or swing toward a proximal end region of a sheath and form an angle of up to at least about 45 degrees, such up to about 60 degrees or up to about 90 degrees, or higher.

Abstract: A medical device includes a clip having an arm member and a pressing tube configured to receive the arm member; an applicator having an operation wire configured to advance and retract to open and close the arm member and a sheath configured to accommodate the operation wire; and a link configured to engage the operation wire with the clip and transition between an engagement configuration in which the clip and the operation wire is engaged with each other and a release configuration in which the engagement of the clip and the operation wire is released.

Abstract: A medical instrument has a capsule; an arm member disposed to protrude from the capsule; an operation wire connected to the arm member; a sheath configured to accommodate the operation wire; and a link configured to connect the sheath with the capsule, wherein the link has an engaging portion including a first surface intersecting with the longitudinal axis; and an engaged portion movable to an opposite position opposite to the first surface and a position spaced away from the first surface in spite of a relative position of the capsule with respect to the sheath, and configured to restrict a separation of the capsule with respect to the sheath when the engaged portion is disposed at the opposition position to contact the first surface, and wherein the capsule is rotatable in response to a rotation force from the sheath when the engaged portion is disposed at the opposition position.

Abstract: The ligation device includes a clip unit, an applicator, and the applicator includes a sheath, an operation wire, a second link that is provided on the operation wire, and is capable of being fitted to the first link at a protrusion position, the second link configured to be restricted a releasing of fitting to the first link at an accommodation position, a slider connected to the operation wire and is configured to move with a first operation, and a limiter including a switch member configured to move in an intersecting direction that intersects a direction of the first operation with a second operation. The limiter is configured to limit a movement range of the slider when the second operation is not performed, and configured to release a limitation of the movement range of the slider with the second operation and to allow the second link to move toward the protrusion position.

Abstract: A ligation device includes a first arm, a second arm, a holding tube, an operation wire, a sheath, and a link mechanism having a first link and a second link which are connected to each other and engage the holding tube with the sheath, wherein the link mechanism is configured to be switch between a disengaged configuration in which engagement between the holding tube and the sheath is released and an engaged configuration in which the holding tube is engaged with the sheath due to the operation wire.

Abstract: A medical device includes: a clip; a wire configured to be capable of operating the clip; a link that detachably connects the clip and the wire; a sheath with an inner diameter that can accommodate the link; a handle connected to the sheath; a slider provided on the handle and configured to be movable relative to the handle, the slider being connected to the wire; a first sheath constituting the sheath, the first sheath having a length such that the link is arranged at a position protruding from the first sheath when the slider is advanced with respect to the handle to a maximum extent; and a second sheath constituting the sheath and connected to the first sheath, the second sheath having a length such that the link is arranged at a position accommodated in the sheath when the slider is advanced with respect to the handle to a maximum extent.

Abstract: A cartridge accommodates a clip unit including an arm member and a tubular housing, and is configured so that the clip unit is able to be mounted in an applicator having a sheath and an operation wire. The cartridge includes a main body in which an insertion hole into which the sheath is inserted is formed and a pusher configured to be movable with respect to the main body. The pusher is configured to come into contact with an engaging member provided in the sheath by moving the sheath with respect to the main body in a state in which the sheath is inserted into the insertion hole. The pusher is configured to push the engaging member against the housing, and to engage the sheath with the housing by engaging the engaging member with both the housing and the sheath.

Abstract: A medical instrument has a capsule; an arm member disposed to protrude from the capsule; an operation wire connected to the arm member; a sheath configured to accommodate the operation wire; and a link configured to connect the sheath with the capsule, wherein the link has an engaging portion including a first surface intersecting with the longitudinal axis; and an engaged portion movable to an opposite position opposite to the first surface and a position spaced away from the first surface in spite of a relative position of the capsule with respect to the sheath, and configured to restrict a separation of the capsule with respect to the sheath when the engaged portion is disposed at the opposition position to contact the first surface, and wherein the capsule is rotatable in response to a rotation force from the sheath when the engaged portion is disposed at the opposition position.

Abstract: A medical instrument has a capsule; an arm member disposed to protrude from the capsule; an operation wire connected to the arm member; a sheath configured to accommodate the operation wire; and a link configured to connect the sheath with the capsule, wherein the link has an engaging portion including a first surface intersecting with the longitudinal axis; and an engaged portion movable to an opposite position opposite to the first surface and a position spaced away from the first surface in spite of a relative position of the capsule with respect to the sheath, and configured to restrict a separation of the capsule with respect to the sheath when the engaged portion is disposed at the opposition position to contact the first surface, and wherein the capsule is rotatable in response to a rotation force from the sheath when the engaged portion is disposed at the opposition position.