Abstract: PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby.

Abstract: PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby.

Abstract: PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby.

Abstract: Objective sequence data (10) which is primary sequence information on an objective protein is entered in an interaction site predicting device by the user. A secondary structure prediction simulation is executed on the objective sequence data (10) entered for secondary structure prediction programs (20a to 20d) that predict a secondary structure of a protein from primary sequence information of the protein. Results of secondary structure prediction (30a to 30d) from the respective secondary structure prediction programs (20a to 20d) are compared (60). Based on the comparison result, frustration of a local portion in the primary sequence information of the objective protein is calculated (70). An interaction site of the objective protein is predicted from the calculated frustration of the local portion (80).

Abstract: There is disclosed a technology of measuring three-dimensional geometric information on a plane and position information on a point from an image such as the optical flow pattern and a stereo image.

Abstract: A data converting device collects time series movement data by measuring a movement of a living thing, encodes the movement data, and stores the encoded data in a storage device. Next, the data converting device generates new encoded data by reading and editing the encoded data. The data converting device then restores the movement data from the encoded data, and reproduces the movement of a virtual character on a display device based on the restored data.

Abstract: In the dialog interface apparatus of the present invention, input speech is converted to an input semantic representation by a speech recognition unit, and a dialog management unit outputs an output semantic representation that corresponds to the input semantic representation, based on the input semantic representation obtained by the speech recognition unit. Having received the output semantic representation from the dialog management unit, a speech synthesis unit converts the output semantic representation to output speech identifying a specific dialog target and outputs the output speech. Further, the dialog management unit outputs to an innate operation execution unit an innate operation command that corresponds to the input semantic representation. The innate operation execution unit receives the innate operation command from the dialog management unit and executes an operation corresponding to the innate operation command.

Abstract: The present invention relates to a neural network system for determining a position of a mobile object such as a robot, automobile, etc., which comprises a return information processing unit for generating return information corresponding to a relative position of the mobile object from the origin in a move space according to first sensor signal from the first sensor; a sense information processing unit for generating sense information corresponding to an environment state surrounding the moblie object at the relative position according to a second sensor signal from the second sensor; and an information integrating unit for inferring return information corresponding to sense information output from the sense information processing unit after learning a correlation between the return information and the sense information, and integrating the two items of information.

Abstract: A system identifying device precisely represents as a mathematical model the features of a system such as a robot manipulator, various industrial plants, etc., and can be operated as hardware by identifying an object system over a neural network, thereby successfully identifying a non-linear system as well as a linear system. Furthermore, an adaptive control device can perform an online learning by using the identifying device to obtain a teaching signal to be used in operating the identifying device in an adaptive control device.

Abstract: Using a writing implement model defined in the O-XYZ coordinate system a character or graphic form is generated on a writing plane model (O-XY plane) defined in the O-XYZ coordinate system. A control polygon for a character or graphical form to be generated is designed in advance in the O-XYZ coordinate system and a smooth writing motion model is generated using local basis functions that are weighted by the coordinate values of the respective vertices of that control polygon. The position component of the writing motion model represents variations in the position of a representative point of the writing implement model in the O-XYZ coordinate system with respect to time, and the posture component of the writing motion model represents time-variations of its inclination in the O-XYZ coordinate system with respect to the O-XYZ coordinate system. The writing implement model and the writing plane model intersect at a time, thereby forming a character segment.