Patents by Inventor Shinya Kida

Shinya Kida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound having PD-L1 expression-suppressing action
    Patent number: 11591297
    Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: February 28, 2023
    Assignees: TOHOKU UNIVERSITY, JUNSEI EDUCATIONAL INSTITUTION, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Haruhisa Kikuchi, Yoshiteru Oshima, Toshio Hattori, Osamu Yamada, Jing Zhang, Shinya Kida, Shinya Murase
  • NOVEL COMPOUND HAVING PD-L1 EXPRESSION-SUPPRESSING ACTION
    Publication number: 20220194900
    Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.
    Type: Application
    Filed: April 8, 2020
    Publication date: June 23, 2022
    Inventors: Haruhisa KIKUCHI, Yoshiteru OSHIMA, Toshio HATTORI, Osamu YAMADA, Jing ZHANG, Shinya KIDA, Shinya MURASE
  • Amide derivative
    Patent number: 11040937
    Abstract: The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R1, R2, R3, R4, R5, R6, R7, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 22, 2021
    Assignees: TOHOKU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Haruhisa Kikuchi, Yoshiteru Oshima, Toshio Hattori, Yuzuru Kubohara, Osamu Yamada, Jing Zhang, Yoshihisa Matsushita, Shinya Kida
  • Indole alkaloid compound having immune checkpoint inhibitory action
    Patent number: 10550120
    Abstract: The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R1, R1?, R2, R2?, R3-R8, and n are as defined in the present specification.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: February 4, 2020
    Assignees: TOHOKU UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Haruhisa Kikuchi, Yoshiteru Oshima, Toshio Hattori, Osamu Yamada, Jing Zhang, Shinya Kida, Shinya Murase
  • INDOLE ALKALOID COMPOUND HAVING IMMUNE CHECKPOINT INHIBITORY ACTION
    Publication number: 20190092774
    Abstract: The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R1, R1?, R2, R2?, R3-R8, and n are as defined in the present specification.
    Type: Application
    Filed: March 24, 2017
    Publication date: March 28, 2019
    Inventors: Haruhisa KIKUCHI, Yoshiteru OSHIMA, Toshio HATTORI, Osamu YAMADA, Jing ZHANG, Shinya KIDA, Shinya MURASE
  • AMIDE DERIVATIVE
    Publication number: 20160368860
    Abstract: The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R1, R2, R3, R4, R5, R6, R7, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 27, 2015
    Publication date: December 22, 2016
    Inventors: Haruhisa Kikuchi, Yoshiteru Oshima, Toshio Hattori, Yuzuru Kubohara, Osamu Yamada, Jing Zhang, Yoshihisa Matsushita, Shinya Kida
  • Osteopontin production inhibitor containing dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient
    Patent number: 9463188
    Abstract: Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin. The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: October 11, 2016
    Assignees: TOHOKU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Haruhisa Kikuchi, Yoshiteru Oshima, Toshio Hattori, Yuzuru Kubohara, Osamu Yamada, Jing Zhang, Yoshihisa Matsushita, Shinya Kida
  • OSTEOPONTIN PRODUCTION INHIBITOR CONTAINING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT
    Publication number: 20150366851
    Abstract: Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin. The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.
    Type: Application
    Filed: November 26, 2013
    Publication date: December 24, 2015
    Applicants: TOHOKU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Haruhisa Kikuchi, Yoshiteru Oshima, Toshio Hattori, Yuzuru Kubohara, Osamu Yamada, Jing Zhang, Yoshihisa Matsushita, Shinya Kida