Patents by Inventor Shinya Kiguchi

Shinya Kiguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220315547
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) comprising: reacting a compound of formula (II) with a compound of formula (III) in the presence of a triazine compound to obtain a compound of formula (IV), and deprotecting said compound of formula (IV) to obtain the compound of formula (I). The compound of formula (I) can be prepared by the process according to the present invention in high yields and high purity. In addition, the process according to the present invention does not use a large amount of solvents or require a purification process of intermediate compounds.
    Type: Application
    Filed: August 27, 2020
    Publication date: October 6, 2022
    Inventors: Shinya Kiguchi, Ganapati G. Bhat, Johnson M. Coutinho, Mikael DAHLSTROM, Michael Lofthagen, Akinori Tatara
  • Patent number: 9051288
    Abstract: Disclosed is a method for mass-producing 4?-ethynyl d4T (4?-ethynyl-2?,3?-didehydro-3?-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4?-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: June 9, 2015
    Assignee: ONCOLYS BIOPHARMA, INC.
    Inventors: Katsuyuki Nagai, Shinya Kiguchi, Hiroya Koyama, William Ewan Hume, Satoshi Tsujimoto
  • Patent number: 8569538
    Abstract: In one aspect, the invention relates to methods of synthesizing acryloyl compounds, comprising the step of hydrosilylating a compound having the structure: with a compound having the structure A-H, wherein A comprises a siloxanyl group, to yield a compound having the structure: Compounds and compositions produced thereby can effectively attain a satisfactory balance between high oxygen permeability and hydrophilicity while achieving an acceptably low concentration of undesirable impurities. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: October 29, 2013
    Assignees: Johnson & Johnson Vision Care, Inc., Toray Industries, Inc.
    Inventors: Masataka Nakamura, Mitsuru Yokota, Takehiro Kohara, Kimihiro Kamasaka, Hiroya Koyama, Shinya Kiguchi, Satoshi Umeda
  • Publication number: 20100280235
    Abstract: Disclosed is a method for mass-producing 4?-ethynyl d4T (4?-ethynyl-2?,3?-didehydro-3?-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4?-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.
    Type: Application
    Filed: December 26, 2008
    Publication date: November 4, 2010
    Applicant: Oncolys Biopharma, Inc
    Inventors: Katsuyuki Nagai, Shinya Kiguchi, Hiroya Koyama, William Ewan Hume, Satoshi Tsujimoto
  • Publication number: 20080119627
    Abstract: Disclosed are reduced pressure distillation methods for purifying siloxanyl monomers in the presence of at least one polymerization inhibitor. In further aspects, the polymerization inhibitor can be an alkylhydroquinone or a hydroxynaphthalene. Also disclosed are compounds purified by the disclosed methods and polymers produced therefrom. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: March 2, 2007
    Publication date: May 22, 2008
    Inventors: Masataka Nakamura, Takehiro Kohara, Hiroya Koyama, Shinya Kiguchi
  • Publication number: 20080004383
    Abstract: In one aspect, the invention relates to methods of synthesizing acryloyl compounds, comprising the step of hydrosilylating a compound having the structure: with a compound having the structure A-H, wherein A comprises a siloxanyl group, to yield a compound having the structure: Compounds and compositions produced thereby can effectively attain a satisfactory balance between high oxygen permeability and hydrophilicity while achieving an acceptably low concentration of undesirable impurities. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 12, 2006
    Publication date: January 3, 2008
    Inventors: Masataka Nakamura, Mitsuru Yokota, Takehiro Kohara, Kimihiro Kamasaka, Hiroya Koyama, Shinya Kiguchi, Satoshi Umeda