Patents by Inventor Shinya Miki
Shinya Miki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220090251Abstract: Provided is a method for forming a thermal sprayed coating, including a step of spraying a non-oxide ceramic material on a substrate to form a coating by a high velocity oxy-fuel spraying process. An average particle size of the non-oxide ceramic material is 0.1 to 5.0 ?m, and a particle size distribution of the non-oxide ceramic material contains one or more peaks in each of: a particle size range of 0.1 ?m or more and less than 1.0 ?m; and a particle size range of 1.0 ?m or more and less than 10.0 ?m. The non-oxide ceramic material is dispersed in a solvent to prepare slurry 11, and the slurry 11 is fed from the exterior to flame 10 jetted from a thermal spray gun 2 to form a dense thermal sprayed coating structure.Type: ApplicationFiled: July 23, 2019Publication date: March 24, 2022Inventors: Shinya MIKI, Masaya NAGAI
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Patent number: 10914342Abstract: A sliding member includes: a base material; a solid lubricant layer arranged on a surface of the base material; a defect layer having a material defect, disposed in the solid lubricant layer, and being changeable into an ultra low friction layer by mechanical stress more easily than changing from the solid lubricant layer to the ultra low friction layer; and a ultra low friction layer covering a surface of the defect layer.Type: GrantFiled: December 21, 2018Date of Patent: February 9, 2021Assignees: DENSO CORPORATION, TOHOKU UNIVERSITY, TOCALO CO., LTD.Inventors: Kentaro Kishi, Yasunori Niiyama, Koshi Adachi, Shinya Miki
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Patent number: 10793818Abstract: The purpose of the present invention is to provide a culture container capable of preventing a concave meniscus without using a jig. In order to achieve this purpose, the present invention provides a culture container (1A) provided with: a base (3) having a concave portion (4); and a water-repellent layer (5) formed on an outer edge region (411) of the bottom (41) of the concave portion (4) and the inner circumferential surface (42) of the concave portion (4). One of the surfaces of the water-repellent layer (5) is exposed to the space in the concave portion (4).Type: GrantFiled: August 19, 2016Date of Patent: October 6, 2020Assignee: TOCALO CO., LTD.Inventors: Shinichi Gomi, Kenichi Kagawa, Yusuke Yoda, Shinya Miki, Tatsuya Hamaguchi
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Patent number: 10507266Abstract: A method according to the present invention for producing a cartilage-damage treatment agent, includes the steps of: (i) proliferating mesenchymal stem cells in a serum-free medium A containing an FGF, a PDGF, a TGF-?, an HGF, an EGF, at least one phospholipid and at least one fatty acid; and (ii) mixing the mesenchymal stem cells thus proliferated in the step (i), an isotonic preserving agent, and a cytoprotective agent. This method provides a cartilage-damage treatment agent which favorably regenerates a cartilage tissue.Type: GrantFiled: August 1, 2014Date of Patent: December 17, 2019Assignee: TWO CELLS Co., Ltd.Inventors: Koichiro Tsuji, Minoru Morikawa, Satoshi Maeda, Yui Kitayama, Aki Ohmori, Jin Chang Shao, Shinichi Hasegawa, Yukio Kato, Takashi Matsushita, Masato Takao, Shinya Miki, Ken Innami, Yasufumi Takahashi
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Publication number: 20190195281Abstract: A sliding member includes: a base material; a solid lubricant layer arranged on a surface of the base material; a defect layer having a material defect, disposed in the solid lubricant layer, and being changeable into an ultra low friction layer by mechanical stress more easily than changing from the solid lubricant layer to the ultra low friction layer; and a ultra low friction layer covering a surface of the defect layer.Type: ApplicationFiled: December 21, 2018Publication date: June 27, 2019Inventors: Kentaro KISHI, Yasunori NIIYAMA, Koshi ADACHI, Shinya MIKI
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Publication number: 20180201892Abstract: The purpose of the present invention is to provide a culture container capable of preventing a concave meniscus without using a jig. In order to achieve this purpose, the present invention provides a culture container (1A) provided with: a base (3) having a concave portion (4); and a water-repellent layer (5) formed on an outer edge region (411) of the bottom (41) of the concave portion (4) and the inner circumferential surface (42) of the concave portion (4). One of the surfaces of the water-repellent layer (5) is exposed to the space in the concave portion (4).Type: ApplicationFiled: August 19, 2016Publication date: July 19, 2018Inventors: Shinichi GOMI, Kenichi KAGAWA, Yusuke YODA, Shinya MIKI, Tatsuya HAMAGUCHI
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Publication number: 20170290623Abstract: There is provided an energy device for surgical operation capable of suppressing fixation of body tissue, wherein a coating layer is formed on an outer periphery of a base material constituting an operational area portion transmitting energy in an energy device for surgical operation operating in the operational area portion, and is comprised of a base coating formed on the base material and an outermost coating formed on the base coating. The base coating is made from silicon oxide or a compound containing silicon oxide, and the outermost coating is made from polysiloxane or a compound containing polysiloxane or a compound containing a partly fluorinated polysiloxane, and the coating layer has a good adhesiveness and is applicable to a complicated form.Type: ApplicationFiled: July 13, 2015Publication date: October 12, 2017Applicants: TOCALO CO., LTD., NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCEInventors: Shinya MIKI, Megumi ADACHI, Toru TANI, Shigeyuki NAKA, Tomoharu SHIMIZU
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Publication number: 20160166734Abstract: A method according to the present invention for producing a cartilage-damage treatment agent, includes the steps of: (i) proliferating mesenchymal stem cells in a serum-free medium A containing an FGF, a PDGF, a TGF-?, an HGF, an EGF, at least one phospholipid and at least one fatty acid; and (ii) mixing the mesenchymal stem cells thus proliferated in the step (i), an isotonic preserving agent, and a cytoprotective agent. This method provides a cartilage-damage treatment agent which favorably regenerates a cartilage tissue.Type: ApplicationFiled: August 1, 2014Publication date: June 16, 2016Inventors: Koichiro TSUJI, Minoru MORIKAWA, Satoshi MAEDA, Yui KITAYAMA, Aki OHMORI, Jin Chang SHAO, Shinichi HASEGAWA, Yukio KATO, Takashi MATSUSHITA, Masato TAKAO, Shinya MIKI, Ken INNAMI, Yasufumi TAKAHASHI
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Patent number: 9238863Abstract: This invention is to provide a fluoride spray coating covered member having excellent resistance to halogen corrosion and resistance to plasma erosion and displaying identification symbols such as letters, numeric characters, graphic, pattern, firm name, serial number and so on. In the invention, one or more implanting gases selected from fluorine-containing gas, oxygen gas and inert gas are ion-implanted onto a white fluoride spray coating formed on a surface of a substrate, whereby at least a part of the surface of the white fluoride spray coating is changed into a black color to form a black ion-implanted layer.Type: GrantFiled: January 16, 2013Date of Patent: January 19, 2016Assignee: TOCALO CO., LTD.Inventors: Yoshio Harada, Takema Teratani, Shinya Miki, Kenichiro Togoe
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Publication number: 20140370249Abstract: This invention is to provide a fluoride spray coating covered member having excellent resistance to halogen corrosion and resistance to plasma erosion and displaying identification symbols such as letters, numeric characters, graphic, pattern, firm name, serial number and so on. In the invention, one or more implanting gases selected from fluorine-containing gas, oxygen gas and inert gas are ion-implanted onto a white fluoride spray coating formed on a surface of a substrate, whereby at least a part of the surface of the white fluoride spray coating is changed into a black color to form a black ion-implanted layer.Type: ApplicationFiled: January 16, 2013Publication date: December 18, 2014Applicant: TOCALO CO., LTD.Inventors: Yoshio Harada, Takema Teratani, Shinya Miki, Kenichiro Togoe
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Patent number: 7259155Abstract: The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R5 is phenyl having on the phenyl ring 1–3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R5 is not mono(lower alkoxy)pheny; and R6 is lower alkyl; and an ACAT-1 inhibitor containing the compound as an active ingredient.Type: GrantFiled: May 5, 2004Date of Patent: August 21, 2007Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Yasuhiro Sakai, Kazuyoshi Miyata, Takahiro Tomoyasu, Akiyoshi Kuroda, Yasuhide Inoue, Akifumi Hagi, Shinya Miki, Norihiro Yoshinaga, Masako Doi, Yoshihiko Tsuda, Seiichirou Kanou
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Publication number: 20050256087Abstract: The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R5 is phenyl having on the phenyl ring 1-3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R5 is not mono(lower alkoxy)pheny; and R6 is lower alkyl; and an ACAT-1 inhibitor containing the compound as an active ingredient.Type: ApplicationFiled: May 5, 2004Publication date: November 17, 2005Inventors: Yasuhiro Sakai, Kazuyoshi Miyata, Takahiro Tomoyasu, Akiyoshi Kuroda, Yasuhide Inoue, Akifumi Hagi, Shinya Miki, Norihiro Yoshinaga, Masako Doi, Yoshihiko Tsuda, Seiichirou Kanou
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Patent number: 5985858Abstract: A phosphonic diester derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a cycloalkyl group; a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen-substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group; a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent; a thiazolyl group; a pyridyl group which may be substituted by a halogen atom; a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring; or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group; R.sup.2 represents a hydrogen atom or a phenyl lower alkyl group; R.sup.3 and R.sup.Type: GrantFiled: June 26, 1998Date of Patent: November 16, 1999Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Kazuyoshi Miyata, Yasuhiro Sakai, Yasuo Shoji, Yoshihiko Tsuda, Yasuhide Inoue, Keigo Sato, Shinya Miki