Patents by Inventor Shinya Ohtsubo
Shinya Ohtsubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10940229Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-?m-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-?m-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.Type: GrantFiled: September 29, 2017Date of Patent: March 9, 2021Assignees: Toray Industries, Inc., Nanotheta Co., Ltd.Inventors: Akihiro Saito, Megumi Nakanishi, Kazuhiro Tanahashi, Toru Arakane, Motonori Hochi, Ai Suzuki, Koji Okabayashi, Shinji Takeoka, Toshinori Fujie, Yuya Ishiduka, Shinya Ohtsubo
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Patent number: 10563025Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation ? defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm?T0?1000 nm, (b) 0.1 ?m?L?500 ?m, (c) 0.01 GPa?E?4.3 GPa, (d) ?=1?T1/T2, (e) 0.346E×10?9?1.499<?<?0.073E×10?9+0.316.Type: GrantFiled: May 11, 2016Date of Patent: February 18, 2020Assignees: Toray Industries, Inc., Nanotheta Co, Ltd.Inventors: Motonori Hochi, Yuki Sekido, Ichiro Itagaki, Toru Arakane, Shinya Ohtsubo, Shinji Takeoka, Atsushi Murata, Mao Fujii, Yuya Ishizuka, Shuichi Shoji, Jun Mizuno, Takashi Kasahara
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Patent number: 10531988Abstract: A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.Type: GrantFiled: December 4, 2015Date of Patent: January 14, 2020Assignees: Toray Industries, Inc., NANOTHETA CO, LTD.Inventors: Motonori Hochi, Yuki Sekido, Akihiro Saito, Shinji Takeoka, Shinya Ohtsubo, Akinari Hinoki, Manabu Kinoshita
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Publication number: 20190216971Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-?m-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-?m-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.Type: ApplicationFiled: September 29, 2017Publication date: July 18, 2019Inventors: Akihiro Saito, Megumi Nakanishi, Kazuhiro Tanahashi, Toru Arakane, Motonori Hochi, Ai Suzuki, Koji Okabayashi, Shinji Takeoka, Toshinori Fujie, Yuya Ishizuka, Shinya Ohtsubo
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Publication number: 20180338865Abstract: A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.Type: ApplicationFiled: December 4, 2015Publication date: November 29, 2018Inventors: Motonori Hochi, Yuki Sekido, Akihiro Saito, Shinji Takeoka, Shinya Ohtsubo, Akinari Hinoki, Manabu Kinoshita
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Publication number: 20180118905Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation ? defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm?T0?1000 nm, (b) 0.1 ?m?L?500 ?m, (c) 0.01 GPa?E?4.3 GPa, (d) ?=1?T1/T2, (e) 0.346E×10?9?1.499<?<?0.073E×10?9+0.316.Type: ApplicationFiled: May 11, 2016Publication date: May 3, 2018Inventors: Motonori Hochi, Yuki Sekido, Ichiro Itagaki, Toru Arakane, Shinya Ohtsubo, Shinji Takeoka, Atsushi Murata, Mao Fujii, Yuya Ishizuka, Shuichi Shoji, Jun Mizuno, Takashi Kasahara
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Patent number: 8948477Abstract: An derivation method of a nail apparatus melanoma discrimination threshold includes a first step of assuming a color image of longitudinal melanonychia as three-dimensional vectors each composed of RGB parameter values of each pixel and finding an angle between each of the three-dimensional vectors and a reference vector, a second step of finding a probability of occurrence according to a frequency distribution of the angles found in the first step, and a third step of finding, according to the probability of occurrence found in the second step, a threshold for a parameter to discriminate whether the longitudinal melanonychia is malignant or benign.Type: GrantFiled: April 22, 2010Date of Patent: February 3, 2015Assignee: Mitaka Kohki Co., Ltd.Inventors: Takayuki Sota, Juzo Fujii, Atsushi Nakamura, Shinya Ohtsubo
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Patent number: 8871252Abstract: The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment. The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.Type: GrantFiled: March 10, 2010Date of Patent: October 28, 2014Assignee: Nanotheta Co, Ltd.Inventors: Shinji Takeoka, Yousuke Obata, Satoru Nakagawa, Shinya Ohtsubo, Yuji Kawasaki
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Publication number: 20120064148Abstract: The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment. The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.Type: ApplicationFiled: March 10, 2010Publication date: March 15, 2012Applicant: BIONANOSHEETER CO., LTD.Inventors: Shinji Takeoka, Yousuke Obata, Satoru Nakagawa, Shinya Ohtsubo, Yuji Kawasaki
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Publication number: 20120041275Abstract: An derivation method of a nail apparatus melanoma discrimination threshold includes a first step of assuming a color image of longitudinal melanonychia as three-dimensional vectors each composed of RGB parameter values of each pixel and finding an angle between each of the three-dimensional vectors and a reference vector, a second step of finding a probability of occurrence according to a frequency distribution of the angles found in the first step, and a third step of finding, according to the probability of occurrence found in the second step, a threshold for a parameter to discriminate whether the longitudinal melanonychia is malignant or benign.Type: ApplicationFiled: April 22, 2010Publication date: February 16, 2012Applicant: MITAKA KOHKI CO., LTD.Inventors: Takayuki Sota, Juzo Fujii, Atsushi Nakamura, Shinya Ohtsubo
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Patent number: 7974670Abstract: A method of processing skin surface observation measuring data which is able to address various sicknesses and reduce an error in sickness detection, and a measuring apparatus requiring no filter. The measuring apparatus an irradiator applying a white light to a biological surface as a sample, a detector detecting the spectra of the white light reflected off a plurality of positions on the biological surface, a plotter plotting the absorbances of the above spectra to a light spectrum multi-dimensional space, an analyzer subjecting data in the spectrum multi-dimension space obtained from the plurality of positions to multivariate analysis to determine the eigenvectors of at least first, second and third principal components, and a display projecting data at respective positions in respective eigenvector directions to display their magnitudes on a two-dimension display screen on a gray scale or in colors corresponding to the magnitudes; and a measuring method by the apparatus.Type: GrantFiled: February 22, 2005Date of Patent: July 5, 2011Assignee: Waseda UniversityInventors: Takayuki Souta, Katsuo Aizawa, Atsushi Nakamura, Satoshi Kageyama, Shinya Ohtsubo, Fumihiko Ichikawa
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Patent number: 7832145Abstract: A device having a shape capable of receiving the plant body to be cultivated. As at least a portion of the device, a film which can substantially be integrated with the root of the plant body is disposed. Such a structure can provide a plant-cultivating device, a plant-film integrate, and a plant-cultivating method which can preferably attain both of the supply of oxygen and the supply of water and a fertilizer component to the root of the plant body.Type: GrantFiled: January 16, 2004Date of Patent: November 16, 2010Assignees: Mebiol Inc.Inventors: Yuichi Mori, Akihiro Okamoto, Makiko Kubota, Shinya Ohtsubo
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Publication number: 20080213869Abstract: Cell/organism is separated by using a hydrogel capable of selectively moving a cell in accordance with a difference in the concentration of a physiologically active substance. The invention provides a hydrogel capable of conducting separation (fractionation, differential separation, fractional collection) of cell/organism having a variety of taxes, which could not be attained in the prior art.Type: ApplicationFiled: October 9, 2007Publication date: September 4, 2008Inventors: Yuichi Mori, Hiroshi Yoshioka, Yuko Sato, Satoru Yoshida, Shinya Ohtsubo
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Publication number: 20070173725Abstract: A method of processing skin surface observation measuring data able to address various sicknesses and reduce an error in sickness detection, and a measuring apparatus requiring no filter with a simple structure. The measuring apparatus comprises a means of applying a white light to a biological surface as a sample, a means of detecting the spectra of the white light reflected off a plurality of positions on the biological surface, a means of plotting the absorbances of the above spectra to a light spectrum multi-dimensional space, a means of subjecting data in the spectrum multi-dimension space obtained from the plurality of positions to multivariate analysis to determine the eigenvectors of at least first, second and third principal components, and a means of projecting data at respective positions in respective eigenvector directions to display their magnitudes on a two-dimension display screen on a gray scale or in colors corresponding to the magnitudes; and a measuring method by the apparatus.Type: ApplicationFiled: February 22, 2005Publication date: July 26, 2007Applicant: Waseda UniversityInventors: Takayuki Souta, Katsuo Aizawa, Atsushi Nakamura, Satoshi Kageyama, Shinya Ohtsubo, Fumihiko Ichikawa
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Publication number: 20060121116Abstract: Cell/organism is separated by using a hydrogel capable of selectively moving a cell in accordance with a difference in the concentration of a physiologically active substance. The invention provides a hydrogel capable of conducting separation (fractionation, differential separation, fractional collection) of cell/organism having a variety of taxes, which could not be attained in the prior art.Type: ApplicationFiled: February 19, 2004Publication date: June 8, 2006Inventors: d Mori, Hiroshi Yoshioka, Yuko Sato, Satoru Yoshida, Shinya Ohtsubo
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Publication number: 20060112632Abstract: A device having a shape capable of receiving the plant body to be cultivated. As at least a portion of the device, a film which can substantially be integrated with the root of the plant body is disposed. Such a structure can provide a plant-cultivating device, a plant-film integrate, and a plant-cultivating method which can preferably attain both of the supply of oxygen and the supply of water and a fertilizer component to the root of the plant body.Type: ApplicationFiled: January 16, 2004Publication date: June 1, 2006Inventors: Yuichi Mori, Akihiro Okamoto, Makiko Kubota, Shinya Ohtsubo