Abstract: A therapeutic agent for HER2-mutated cancer comprising, as an active component, an anti-HER2 antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents a connecting position to an anti-HER2 antibody) is conjugated to the antibody via a thioether bond and/or a method of treatment for cancer, comprising administering the anti-HER2 antibody-drug conjugate to a subject determined to have HER2-mutated cancer.

Abstract: Method for treating Alzheimer's disease, Parkinson's disease, Huntington's chorea or Pick's disease by administering to a patient a compound of formula (I) wherein R1 represents hydrogen; R2 represents hydrogen, a C1-C6 alkyl group or C3-C6 cycloalkyl group; A represents nitrogen; D represents a methylene group, a methyl methylene group, a halogen atom substituted methylene group or a halogen substituted methyl methylene group; E represents CH2, CHR3 wherein R3 represents a C1-C6 alkyl group, CH or a carbon atom substituted by a C1-C6 alkyl group; Arom represents aryl, aryl having from 1 to 3 identical or different substituent groups selected from halogen, C1-C6 alkyl, and C1-C6 alkyloxy, heteroaryl or heteroaryl having from 1 to 3 substituent groups, selected from halogen, C1-C6 alkyl and C1-C6 alkyloxy. The part represented by is a single bond or double bond.

Abstract: A medicine for central diseases which contains as the active ingredient either a compound represented by the general formula (I): (I) (wherein R1 represents hydrogen or C1-6 alkyl; R2 represents C1-6 alkyl, etc.; A represents carbon, etc.; D represents C1-6 alkylene, etc.; E represents carbon, etc.; and Arom represents aryl, etc.) or a pharmacologically acceptable salt of the compound.

Abstract: A medicine for central diseases which contains as the active ingredient either a compound represented by the general formula (I): (I) (wherein R1 represents hydrogen or C1-6 alkyl; R2 represents C1-6 alkyl, etc.; A represents carbon, etc.; D represents C1-6 alkylene, etc.; E represents carbon, etc.; and Arom represents aryl, etc.) or a pharmacologically acceptable salt of the compound.