Abstract: An electrically driven vehicle includes a floor panel, a tunnel section, an electrical storage device, and an electric power line. The tunnel section is formed in a vehicle forward/rearward direction in a central portion of the floor panel in a vehicle width direction. The electrical storage device is disposed behind the tunnel section of the vehicle above the floor panel. The electric power line is disposed below the tunnel section and connected to the electrical storage device. The tunnel section has an opening portion formed in a rear end portion of the tunnel section located in front of the electrical storage device of the vehicle and through which the electric power line is inserted.

Abstract: A substrate processing apparatus comprising a plasma processing chamber having a substrate support therein which supports a substrate. A shower head faces the substrate support and includes a shower plate formed with a plurality of gas introduction ports through each of which a gas is discharged. A cooling plate holds the shower plate and is formed with a coolant passage through which a coolant is supplied. A plurality of gas diffusion chambers are formed between the shower plate and the cooling plate, and each of the plurality of gas diffusion chambers communicates with each of a plurality of gas supply flow paths and one or more of the plurality of gas introduction ports, respectively. At least a part of the coolant passage is disposed above a heat transfer surface between the shower plate and the cooling plate, in a plan view.

Abstract: An upper electrode disclosed forms a shower head in a capacitively-coupled plasma processing apparatus. The upper electrode includes a first member, a second member, and a third member. The first member is formed of a conductor. The first member provides a first gas hole. The first gas hole penetrates the first member. The second member is formed of a conductor. The second member is provided on the first member. The second member provides a second gas hole. The third member is formed of a dielectric. The third member is provided between the first member and the second member. The third member defines the gas diffusion chamber. The first gas hole and the second gas hole are connected to the gas diffusion chamber.

Abstract: A method of producing an induced pluripotent stem cell, comprising the step of introducing at least one kind of non-viral expression vector incorporating at least one gene that encodes a reprogramming factor into a somatic cell. In some embodiments, the gene that encodes a reprogramming factor is one or more kind of genes selected from the group consisting of an Oct family gene, a Klf family gene, a Sox family gene, a Myc family gene, a Lin family gene, and the Nanog gene.

Abstract: There is provided a substrate processing apparatus including: a processing chamber; a substrate support that is disposed in the processing chamber and holds a substrate; and a shower head facing the substrate support, the shower head including a shower plate formed with a gas flow path through which a gas is discharged, and a cooling plate holding and cooling the shower plate, and the cooling plate including a first plate having a gas distribution layer through which the gas is distributed, a second plate having a coolant passage through which a coolant is supplied and a gas diffusion space into which the gas distributed by the gas distribution layer is supplied, and a fastening member fastening the first plate and the second plate.

Abstract: A recombinant vector for producing an induced pluripotent stem cell, including an Oct family gene, a Klf family gene, and a Myc family gene, wherein the genes are inserted in the vector and an induced pluripotent stem cell including the recombinant vector. Also disclosed is a method for preparing a recombinant vector for producing an induced pluripotent stem cell, including inserting each of the three genes into a vector such that the genes are capable of expression. Also disclosed are a first recombinant vector for preparing a second recombinant vector for producing an induced pluripotent stem cell, said first recombinant vector including at least two of the following four genes: an Oct family gene, a Klf family gene, a Myc family gene and a Sox family gene. Also disclosed is a method for preparing the first recombinant vector, including inserting the at least two genes into a vector.

Abstract: A method of producing an induced pluripotent stem cell includes introducing into a somatic cell one or more non-viral expression vectors. The vectors include one or more of an Oct family gene, a Klf family gene, a Sox family gene, a Myc family gene, a Lin family gene, and Nanog gene. The somatic cell is then cultured in a medium that supports pluripotent stem cells. At least a portion of the one or more introduced non-viral expression vectors is not substantially integrated in the chromosome.

Abstract: A hydraulic excavator includes a revolving frame forming a support structure, a cab that is disposed to be positioned on a front side of the revolving frame and in which an operator gets, and a plurality of vibration isolating members that are disposed between the revolving frame and the cab to support the cab on the revolving frame in a vibration isolating state. Further, an intermediate connecting member is disposed for connection between the revolving frame and the vibration isolating member and for a height position adjustment of the cab to the revolving frame. The intermediate connecting member is fixed to the revolving frame from a lower side.

Abstract: The present invention provides a production method of iPS cell, including a step of introducing the following (1) and (2): (1) an episomal vector containing a nuclear reprogramming factor; and (2) an episomal vector containing EBNA-1, which is different from (1), into a somatic cell, as well as a method for improving iPS cell establishment efficiency. The present invention also provides an agent for improving iPS cell establishment efficiency, which contains an episomal vector containing a nucleic acid encoding EBNA-1, and a kit for producing an iPS cell further containing an episomal vector containing a nucleic acid encoding a nuclear reprogramming factor.

Abstract: The invention provides an in vitro method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells. The method comprises contacting an isolated somatic cell being reprogrammed into an iPS cell with an inhibitor of p53 function. The invention also provides an in vitro method of producing iPS cells. The method comprises bringing (a) nuclear reprogramming substances or nucleic acids encoding the nuclear reprogramming substances and (b) an inhibitor of p53 function into contact with a somatic cell.

Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.

Abstract: A method for producing hematopoietic stem cells and/or hematopoietic progenitor cells from pluripotent stem cells is described. The method includes a step of culturing pluripotent stem cells in the presence of IGF2. A method is described for selecting an induced pluripotent stem cell(s) having high capacity to differentiate into hematopoietic stem cells and/or hematopoietic progenitor cells, or into blood cells, based on the expression level(s) of one or more genes such as TRIM58, CTSF, FAM19A5, and TCERG1L genes, or on the DNA methylation state(s) of the TRIM58, CSMD1, and/or FAM19A5 gene(s).

Abstract: A hydraulic excavator includes a revolving frame forming a support structure, a cab that is disposed to be positioned on a front side of the revolving frame and in which an operator gets, and a plurality of vibration isolating members that are disposed between the revolving frame and the cab to support the cab on the revolving frame in a vibration isolating state. Further, an intermediate connecting member is disposed for connection between the revolving frame and the vibration isolating member and for a height position adjustment of the cab to the revolving frame. The intermediate connecting member is fixed to the revolving frame from a lower side.

Abstract: The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.

Abstract: The present invention provides a method for producing or detecting cardiomyocytes by extracting/detecting cardiomyocytes from a cell population which includes cardiomyocytes using, as an index, positivity of NCAM1, SSEA3, SSEA4 and/or CD340.

Abstract: A temperature measurement device includes a light emitting part including a first light source configured to output measurement light with a first wavelength and a second light source configured to output reference light with a second wavelength, a light receiving part configured to receive reflected light of the measurement light and reflected light of the reference light that have passed through a temperature sensing device that changes light transmission characteristics with changes in temperature, a control part configured to measure a temperature detected by the temperature sensing device based on an amount of light of the received reflected light of the measurement light and an amount of light of the received reflected light of the reference light, and a temperature adjustment part configured to separately adjust the temperature of the first light source and the temperature of the second light source.

Abstract: The present invention provides a method of improving iPS cell establishment efficiency, comprising contacting a protein involved in primitive streak (PrS) formation, preferably Foxh1, or a nucleic acid that encodes the same with a somatic cell in a nuclear reprogramming step. Also provided is a method of producing an iPS cell, comprising contacting the protein involved in PrS formation or a nucleic acid that encodes the same, and nuclear reprogramming substance(s) with a somatic cell.

Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.

Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.

Abstract: The present invention provides a method for producing or detecting cardiomyocytes by extracting/detecting cardiomyocytes from a cell population which includes cardiomyocytes using, as an index, positivity of NCAM1, SSEA3, SSEA4 and/or CD340.