Patents by Inventor Shinya Yamanaka

Shinya Yamanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200172875
    Abstract: A method of producing an induced pluripotent stem cell includes introducing into a somatic cell one or more non-viral expression vectors. The vectors include one or more of an Oct family gene, a Klf family gene, a Sox family gene, a Myc family gene, a Lin family gene, and Nanog gene. The somatic cell is then cultured in a medium that supports pluripotent stem cells. At least a portion of the one or more introduced non-viral expression vectors is not substantially integrated in the chromosome.
    Type: Application
    Filed: December 3, 2019
    Publication date: June 4, 2020
    Inventors: Shinya Yamanaka, Keisuke Okita
  • Patent number: 10611413
    Abstract: A hydraulic excavator includes a revolving frame forming a support structure, a cab that is disposed to be positioned on a front side of the revolving frame and in which an operator gets, and a plurality of vibration isolating members that are disposed between the revolving frame and the cab to support the cab on the revolving frame in a vibration isolating state. Further, an intermediate connecting member is disposed for connection between the revolving frame and the vibration isolating member and for a height position adjustment of the cab to the revolving frame. The intermediate connecting member is fixed to the revolving frame from a lower side.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: April 7, 2020
    Assignee: Hitachi Construction Machinery Co., Ltd.
    Inventor: Shinya Yamanaka
  • Patent number: 10519425
    Abstract: The present invention provides a production method of iPS cell, including a step of introducing the following (1) and (2): (1) an episomal vector containing a nuclear reprogramming factor; and (2) an episomal vector containing EBNA-1, which is different from (1), into a somatic cell, as well as a method for improving iPS cell establishment efficiency. The present invention also provides an agent for improving iPS cell establishment efficiency, which contains an episomal vector containing a nucleic acid encoding EBNA-1, and a kit for producing an iPS cell further containing an episomal vector containing a nucleic acid encoding a nuclear reprogramming factor.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: December 31, 2019
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Keisuke Okita
  • Publication number: 20190309263
    Abstract: The invention provides an in vitro method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells. The method comprises contacting an isolated somatic cell being reprogrammed into an iPS cell with an inhibitor of p53 function. The invention also provides an in vitro method of producing iPS cells. The method comprises bringing (a) nuclear reprogramming substances or nucleic acids encoding the nuclear reprogramming substances and (b) an inhibitor of p53 function into contact with a somatic cell.
    Type: Application
    Filed: November 19, 2018
    Publication date: October 10, 2019
    Applicant: Kyoto University
    Inventors: Shinya Yamanaka, Kazutoshi Takahashi, Keisuke Okita
  • Patent number: 10385407
    Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: August 20, 2019
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Kazutoshi Takahashi, Michiyo Koyanagi, Mari Ohnuki
  • Patent number: 10345516
    Abstract: [Object] In an optical fiber cable including a plurality of optical fiber units each formed by tying optical fibers in a bundle, preferable water resistance is to be achieved without increasing an outer diameter of the optical fiber cable. [Solution] An optical fiber cable includes: a plurality of optical fiber units each including a plurality of optical fibers and a bundling member wound around an outer periphery of a bundle of the plurality of optical fibers, the bundling member having a surface to which a water-absorbent granular substance is detachably attached.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: July 9, 2019
    Assignees: FUJIKURA LTD., NIPPON TELEGRAPH AND TELEPHONE CORPORATION
    Inventors: Yoshie Sajima, Kouji Tomikawa, Ken Osato, Masayoshi Yamanaka, Naoki Okada, Shinya Hamaguchi, Naoki Nakagawa, Yusuke Yamada, Hisaaki Nakane
  • Patent number: 10240126
    Abstract: A method for producing hematopoietic stem cells and/or hematopoietic progenitor cells from pluripotent stem cells is described. The method includes a step of culturing pluripotent stem cells in the presence of IGF2. A method is described for selecting an induced pluripotent stem cell(s) having high capacity to differentiate into hematopoietic stem cells and/or hematopoietic progenitor cells, or into blood cells, based on the expression level(s) of one or more genes such as TRIM58, CTSF, FAM19A5, and TCERG1L genes, or on the DNA methylation state(s) of the TRIM58, CSMD1, and/or FAM19A5 gene(s).
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: March 26, 2019
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Masatoshi Nishizawa
  • Publication number: 20190023328
    Abstract: A hydraulic excavator includes a revolving frame forming a support structure, a cab that is disposed to be positioned on a front side of the revolving frame and in which an operator gets, and a plurality of vibration isolating members that are disposed between the revolving frame and the cab to support the cab on the revolving frame in a vibration isolating state. Further, an intermediate connecting member is disposed for connection between the revolving frame and the vibration isolating member and for a height position adjustment of the cab to the revolving frame. The intermediate connecting member is fixed to the revolving frame from a lower side.
    Type: Application
    Filed: August 2, 2017
    Publication date: January 24, 2019
    Inventor: Shinya YAMANAKA
  • Publication number: 20180371036
    Abstract: The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
    Type: Application
    Filed: March 30, 2017
    Publication date: December 27, 2018
    Inventors: Shinya Yamanaka, Kazutoshi Takahashi, Masato Nakagawa
  • Patent number: 10150949
    Abstract: The present invention provides a method for producing or detecting cardiomyocytes by extracting/detecting cardiomyocytes from a cell population which includes cardiomyocytes using, as an index, positivity of NCAM1, SSEA3, SSEA4 and/or CD340.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: December 11, 2018
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Shunsuke Funakoshi
  • Patent number: 10139289
    Abstract: A temperature measurement device includes a light emitting part including a first light source configured to output measurement light with a first wavelength and a second light source configured to output reference light with a second wavelength, a light receiving part configured to receive reflected light of the measurement light and reflected light of the reference light that have passed through a temperature sensing device that changes light transmission characteristics with changes in temperature, a control part configured to measure a temperature detected by the temperature sensing device based on an amount of light of the received reflected light of the measurement light and an amount of light of the received reflected light of the reference light, and a temperature adjustment part configured to separately adjust the temperature of the first light source and the temperature of the second light source.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: November 27, 2018
    Assignee: Tokyo Electron Limited
    Inventors: Takari Yamamoto, Kenichiro Yamada, Shinya Yamanaka
  • Patent number: 10077429
    Abstract: The present invention provides a method of improving iPS cell establishment efficiency, comprising contacting a protein involved in primitive streak (PrS) formation, preferably Foxh1, or a nucleic acid that encodes the same with a somatic cell in a nuclear reprogramming step. Also provided is a method of producing an iPS cell, comprising contacting the protein involved in PrS formation or a nucleic acid that encodes the same, and nuclear reprogramming substance(s) with a somatic cell.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: September 18, 2018
    Assignee: Kyoto University
    Inventors: Kazutoshi Takahashi, Koji Tanabe, Shinya Yamanaka
  • Publication number: 20180195134
    Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
    Type: Application
    Filed: March 1, 2018
    Publication date: July 12, 2018
    Applicant: KYOTO UNIVERSITY
    Inventors: Shinya YAMANAKA, Kazutoshi TAKAHASHI, Michiyo KOYANAGI, Mari OHNUKI
  • Patent number: 9938585
    Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: April 10, 2018
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Kazutoshi Takahashi, Michiyo Koyanagi, Mari Ohnuki
  • Publication number: 20170335285
    Abstract: The present invention provides a method for producing or detecting cardiomyocytes by extracting/detecting cardiomyocytes from a cell population which includes cardiomyocytes using, as an index, positivity of NCAM1, SSEA3, SSEA4 and/or CD340.
    Type: Application
    Filed: June 12, 2017
    Publication date: November 23, 2017
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Shunsuke Funakoshi
  • Patent number: 9822342
    Abstract: The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating embryoid bodies obtained during the production process, and allowing reaggregation of the resulting cells to allow formation of embryoid bodies.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 21, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Kenji Miki
  • Publication number: 20170253934
    Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 7, 2017
    Applicant: KYOTO UNIVERSITY
    Inventors: Shinya YAMANAKA, Kazutoshi TAKAHASHI, Michiyo KOYANAGI, Mari OHNUKI
  • Publication number: 20170176264
    Abstract: A temperature measurement device includes a light emitting part including a first light source configured to output measurement light with a first wavelength and a second light source configured to output reference light with a second wavelength, a light receiving part configured to receive reflected light of the measurement light and reflected light of the reference light that have passed through a temperature sensing device that changes light transmission characteristics with changes in temperature, a control part configured to measure a temperature detected by the temperature sensing device based on an amount of light of the received reflected light of the measurement light and an amount of light of the received reflected light of the reference light, and a temperature adjustment part configured to separately adjust the temperature of the first light source and the temperature of the second light source.
    Type: Application
    Filed: February 25, 2015
    Publication date: June 22, 2017
    Inventors: Takari YAMAMOTO, Kenichiro YAMADA, Shinya YAMANAKA
  • Patent number: 9683232
    Abstract: This relates to a method of preparing induced pluripotent stem cells, comprising a nuclear reprogramming step with a nuclear reprogramming factor in the presence of miRNA, wherein said miRNA has a property of providing a higher nuclear reprogramming efficiency in the presence of said miRNA than in the absence thereof.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: June 20, 2017
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Michiyo Koyanagi
  • Patent number: 9677141
    Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: June 13, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Kazutoshi Takahashi, Michiyo Koyanagi, Mari Ohnuki