Abstract: Parenteral extravascular administration of a composition containing an analgesic medication of low water solubility that is dissolved, suspended, or emulsified in a solvent system results in the deposition of the analgesic medication at the site of administration and provides a controlled release of the analgesic medication from the site and a prolonged analgesia that may persist for several days following administration.

Abstract: Functional imaging information is used to determine a probability of residual disease given a treatment. The functional imaging information shows different characteristic levels for different regions of the tumor. The probability is output for planning use and/or used to automatically determine dose by region. Using the probability, the dose may be distributed by region so that some regions receive a greater dose than other regions. This distribution by region of dose more likely treats the tumor with a same dose, allows a lesser dose to sufficient treat the tumor, and/or allows a greater dose with a lesser or no increase in risk to normal tissue. The dose plan may account for personalized tumors as each patient may have distinct tumors. Probability of dose application accuracy may also be used, so that a combined treatment probability allows efficient dose planning.

Abstract: A system for modeling complete response prediction is provided. The system includes an input that is operable to receive treatment information representing treatment data that may be used to predict a complete response of a tumor. The complete response may include a disappearance of all or substantially all of a disease. A processor may be operable to use a model to predict complete response of the tumor as a function of the treatment data. The model represents a probability of complete response to treatment given the treatment data. A display is operable to output an image as a function of the complete response prediction.

Abstract: Modeling of prognosis of survivability, side-effect, or both is provided. For example, RILI is predicted using bullae information. The amount, volume or ratio of Bullae, even alone, may indicate the likelihood of complication, such as the likelihood of significant (e.g., stage 3) pneumonitis. As another example, RILI is predicted using uptake values of an imaging agent. Standardized uptake from a functional image (e.g., FDG uptake from a positron emission image), alone or in combination with other features, may indicate the likelihood of side-effect. In another example, survivability, such as two-year survivability, is predicted using blood biomarkers. The characteristics of a patient's blood may be measured and, alone or in combination with other features, may indicate the likelihood of survival. The modeling may be for survivability, side-effect, or both and may use one or more of the blood biomarker, uptake value, and bullae features.

Abstract: A computer-implemented method for privacy-preserving data mining to determine cancer survival rates includes providing a random matrix B agreed to by a plurality of entities, wherein each entity i possesses a data matrix Ai of cancer survival data that is not publicly available, providing a class matrix Di for each of the data matrices Ai, providing a kernel K(Ai, B) by each of said plurality of entities to allow public computation of a full kernel, and computing a binary classifier that incorporates said public full kernel, wherein said classifier is adapted to classify a new data vector according to a sign of said classifier.

Abstract: A method for training a classifier for use in a computer aided detection system includes providing a training set of images acquired from a plurality of patients, each said image including one or more candidate regions that have been identified as suspicious by a candidate generation step of a computer aided detection system, and wherein each said image has been manually annotated to identify lesions, using said training set to train a classifier adapted for identifying a candidate region as a lesion or non-lesion, clustering candidate regions having similar features for each patient individually, and modifying said trained classifier decision boundary with an additional classification step incorporating said individual candidate region clustering.

Abstract: A method for training classifiers for ICD-9 patient codes includes providing a set of documents regarding patient hospital visits, combining the documents for each patient visit to create a hospital visit profile, defining a feature as an ngram with a frequency of occurrence greater or equal to a predetermined value that does not appear in a standard list of ngrams, processing the profiles to remove redundancy at a paragraph level and perform tokenization and sentence splitting, performing feature selection, randomly dividing the documents into training, validation, and test sets, and training a set of binary classifiers using a weighted ridge regression, each binary classifier targeting a single ICD-9 code using the training set, wherein each classifier is adapted to determining a specific ICD-9 code by analyzing a patient's hospital records.

Abstract: Vision-based document segmentation identifies one or more portions of semantic content of a document. The one or more portions are identified by identifying a plurality of visual blocks in the document, and detecting one or more separators between the visual blocks of the plurality of visual blocks. A content structure for the document is constructed based at least in part on the plurality of visual blocks and the one or more separators, and the content structure identifies the one or more portions of semantic content of the document. The content structure obtained using the vision-based document segmentation can optionally be used during document retrieval.

Abstract: Vision-based document segmentation identifies one or more portions of semantic content of a document. The one or more portions are identified by identifying a plurality of visual blocks in the document, and detecting one or more separators between the visual blocks of the plurality of visual blocks. A content structure for the document is constructed based at least in part on the plurality of visual blocks and the one or more separators, and the content structure identifies the one or more portions of semantic content of the document. The content structure obtained using the vision-based document segmentation can optionally be used during document retrieval.

Abstract: Vision-based document segmentation identifies one or more portions of semantic content of a document. The one or more portions are identified by identifying a plurality of visual blocks in the document, and detecting one or more separators between the visual blocks of the plurality of visual blocks. A content structure for the document is constructed based at least in part on the plurality of visual blocks and the one or more separators, and the content structure identifies the one or more portions of semantic content of the document. The content structure obtained using the vision-based document segmentation can optionally be used during document retrieval.