Abstract: Methods of identifying one or more genomic regions associated with kidney disease and/or its treatment are described. The methods include administering a glucocorticoid to a first group of subjects; administering a thiazolidinedione to a second group of subjects; and identifying a plurality of genomic regions affected in the first group and the second group, wherein the subjects have a kidney disease or are animal models of a kidney disease. Methods of identifying a drug for treatment of nephrotic syndrome are also described.

Abstract: A method of treating or preventing glomerular disease or chronic kidney disease in a subject is described. The method includes administering to the subject a therapeutically effective amount of PPAR? agonist or a pharmaceutically acceptable salt thereof.

Abstract: A system and method for determining optimal selection of paths for passively monitoring a communications network. A diagnostic set of paths is determined by ensuring that, for all pairs of links in the network, the set contains one path having only one member of that pair. A detection subset of paths is determined by ensuring that, for all the links in the network, one member of the subset contains that link. Selecting a minimum detection and diagnostic set of paths minimizes the communication overhead imposed by monitoring. During normal operation, only the detection subset need be monitored. Once an anomaly is detected, the system may switch to monitoring the full diagnostic set. The cost of deploying and operating the passive monitoring equipment is minimized by determining the minimum set of links on which a probe needs to be placed in order to monitor the diagnostic set of paths.

Abstract: A system and method for determining optimal selection of paths for passively monitoring a communications network. A diagnostic set of paths is determined by ensuring that, for all pairs of links in the network, the set contains one path having only one member of that pair. A detection subset of paths is determined by ensuring that, for all the links in the network, one member of the subset contains that link. Selecting a minimum detection and diagnostic set of paths minimizes the communication overhead imposed by monitoring. During normal operation, only the detection subset need be monitored. Once an anomaly is detected, the system may switch to monitoring the full diagnostic set. The cost of deploying and operating the passive monitoring equipment is minimized by determining the minimum set of links on which a probe needs to be placed in order to monitor the diagnostic set of paths.