Patents by Inventor SHIRAZ MUJTABA

SHIRAZ MUJTABA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of suppressing gene transcription through histone lysine methylation
    Patent number: 10280408
    Abstract: The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine mehtyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: May 7, 2019
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Ming-ming Zhou, Shiraz Mujtaba
  • METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION
    Publication number: 20160137989
    Abstract: The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine methyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
    Type: Application
    Filed: January 21, 2016
    Publication date: May 19, 2016
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Ming-ming Zhou, Shiraz Mujtaba
  • Method of suppressing gene transcription through histone lysine methylation
    Patent number: 9249190
    Abstract: The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine methyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: February 2, 2016
    Assignee: MOUNT SINAI SCHOOL OF MEDICINE
    Inventors: Ming-ming Zhou, Shiraz Mujtaba
  • INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION
    Publication number: 20140066410
    Abstract: This disclosure relates generally to compounds and compositions comprising one or more diphenylethylene, diphenylethylyne, and azobenzene analogs. These compounds are useful for treating diseases associated with NF-kB and p53 activity, such as cancer and inflammatory disease.
    Type: Application
    Filed: February 23, 2012
    Publication date: March 6, 2014
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Ming-Ming Zhou, Michael Ohlmeyer, Shiraz Mujtaba, Alexander Plotnikov, David Kastrinsky, Guangtao Zhang
  • Method of Suppressing Gene Transcription Through Histone Lysine Methylation
    Publication number: 20110123511
    Abstract: The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine mehtyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
    Type: Application
    Filed: October 1, 2010
    Publication date: May 26, 2011
    Applicant: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
    Inventors: MING-MING ZHOU, SHIRAZ MUJTABA