Patents by Inventor Shireen Goh

Shireen Goh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11827871
    Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially constant.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: November 28, 2023
    Assignees: Massachusetts Institute of Technology, Sanofi
    Inventors: Shireen Goh, Rajeev Jagga Ram, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20230356223
    Abstract: An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.
    Type: Application
    Filed: May 10, 2023
    Publication date: November 9, 2023
    Inventors: Shireen GOH, Shan Mei TAN
  • Patent number: 11725176
    Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
    Type: Grant
    Filed: August 29, 2022
    Date of Patent: August 15, 2023
    Assignees: Sanofi, Massachusetts Institute Of Technology
    Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20220411741
    Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
    Type: Application
    Filed: August 29, 2022
    Publication date: December 29, 2022
    Applicants: Sanofi, Massachusetts Institute of Technology
    Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
  • Patent number: 11459538
    Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: October 4, 2022
    Assignees: Sanofi, Massachusetts Institute of Technology
    Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20200063082
    Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially contstant.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 27, 2020
    Inventors: Shireen Goh, Rajeev Jagga Ram, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20200040298
    Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
    Type: Application
    Filed: October 16, 2019
    Publication date: February 6, 2020
    Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
  • Patent number: 10479973
    Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially constant.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: November 19, 2019
    Assignees: Massachuesetts Institute of Technology, Sanofi
    Inventors: Shireen Goh, Rajeev Jagga Ram, Michelangelo Canzoneri, Horst Blum
  • Patent number: 10472602
    Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: November 12, 2019
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Sanofi
    Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20190275521
    Abstract: An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. In an embodiment, multiple inertial microfluidic devices are connected in sequence for combined inner wall and outer wall focusing. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.
    Type: Application
    Filed: July 21, 2017
    Publication date: September 12, 2019
    Inventors: Shireen GOH, Shan Mei TAN
  • Publication number: 20170107473
    Abstract: Strategies to control the level of dissolved carbon dioxide (CO2) concentrations and/or pH in small volume reactor chambers, and associated articles, systems, and methods, are generally provided. In certain embodiments, the reactor chambers can be configured to contain at least one biological cell.
    Type: Application
    Filed: May 20, 2016
    Publication date: April 20, 2017
    Applicants: Massachusetts Institute of Technology, Sanofi
    Inventors: Shireen Goh, Rajeev Jagga Ram, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20160215246
    Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially constant.
    Type: Application
    Filed: August 22, 2014
    Publication date: July 28, 2016
    Applicants: Massachusetts Institute of Technology, Sanofi
    Inventors: Shireen Goh, Rajeev Jagga Ram, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20140127802
    Abstract: Strategies to control the level of dissolved carbon dioxide (CO2) concentrations and/or pH in small volume reactor chambers, and associated articles, systems, and methods, are generally provided. In certain embodiments, the reactor chambers can be configured to contain at least one biological cell.
    Type: Application
    Filed: October 25, 2013
    Publication date: May 8, 2014
    Applicants: sanofi, Massachusetts Institute of Technology
    Inventors: Shireen Goh, Rajeev Jagga Ram, Michelangelo Canzoneri, Horst Blum
  • Publication number: 20140120609
    Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
    Type: Application
    Filed: October 25, 2013
    Publication date: May 1, 2014
    Applicants: Sanofi, Massachusetts Institute of Technology
    Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum