Abstract: The invention relates to novel methods and compositions for conferring tolerance to glyphosate to plants. The invention also provides glyphosate-tolerant plants, seeds, tissue, cells, and plant parts comprising modified EPSP synthases and recombinant DNA molecules encoding modified EPSP synthases, as well as methods of producing the same and the use thereof.

Abstract: The present invention provides methods and compositions for treating a cancer, and/or an autoimmune disease, by modulating the expression and/or activity of IGSF8 and its binding ligands. The pharmaceutical compositions may include, but are not limited to, antibodies that specifically bind human IGSF8, and have an activity of inhibiting IGSF8-mediated immunosuppression in a subject in need thereof.

Abstract: Described here are methods of assessing response of a patient to an EZH2 inhibitor and methods of treating certain cancers by administering therapeutically effective amounts of an EZH2 inhibitor and a PARP-1 inhibitor.

Abstract: A pinch valve mechanism for use in a suction/irrigator device, wherein the device has a conduit for suction/irrigation. The pinch valve mechanism includes a first end having a first projection, a second end, operatively connected to the first end and a second projection. A spring means operatively connected to the second end, wherein the conduit is disposed between the first end and the second end such that the first projection and second projection are biased to pinch the conduit into a closed position. Compression of the spring means moves the first end away from the second end to move the conduit into an open position.

Abstract: The invention is directed to an apparatus for providing suction and irrigation to a body site. The apparatus includes a shaft having a distal end for juxtaposition with the body site, and an actuating mechanism operatively configured to facilitate selective actuation of the apparatus to provide either suction or irrigation via the shaft. The shaft has a flow area restriction portion located proximate its distal end.

Abstract: Methods, processes and systems for using solid catalysts to simultaneously produce lactic acid and propylene glycol from glycerol are provide, as are methods, processes and systems of converting glycerol use heterogeneous catalytic agents. Different combinations of catalysts and reaction conditions provide tunable ranges for the yields of lactic acid and propylene glycol. The conversion methods, processes and systems are not reliant on external hydrogen. Applications to crude glycerol, including that co-produced during biodiesel production, are also described.