Patents by Inventor Shiro Akinaga

Shiro Akinaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6H-pyrazolo-[4,5,1-d,e]acridin-6-one derivatives having anit-tumor activity
    Patent number: 5079358
    Abstract: Novel pyrazoloacridone compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: January 7, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Toru Sugaya, Yukiteru Mimura, Yasushi Shida, Yutaka Osawa, Ikuo Matsukuma, Shiro Akinaga, Makoto Morimoto
  • UCN-1028A and UCN-1028C and process for the production thereof
    Patent number: 4992570
    Abstract: UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.
    Type: Grant
    Filed: March 24, 1988
    Date of Patent: February 12, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Eiji Kobayashi, Isami Takahashi, Katsuhiko Ando, Mayumi Yoshida, Shiro Akinaga, Takao Iida
  • Derivatives of physiologically active substance K-252
    Patent number: 4923986
    Abstract: The present invention relates to novel derivatives of K-252, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-ep oxy-1H,8H, 11H-2,7b,11a-triazadibenzo[a,g]cycloocta-[c,d,e,]trinden-1-one, and the compounds are represented by formula (I): ##STR1## wherein W.sub.1, W.sub.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y represent various substituents. The compounds are physiologically active substances that inhibit protein kinase C and exhibit an antitumor activity, and are useful as medicines.
    Type: Grant
    Filed: November 8, 1988
    Date of Patent: May 8, 1990
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Chikara Murakata, Akira Sato, Mitsuru Takahashi, Eiji Kobayashi, Makoto Morimoto, Shiro Akinaga, Tadashi Hirata, Kenichi Mochida, Hiroshi Kase, Koji Yamada, Kazuyuki Iwashashi
  • K-252 compounds
    Patent number: 4877776
    Abstract: A K-252 compound represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently H or OH; X represents COOH, COOR or CH.sub.2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl has C-kinase inhibitory activity and is expected to be useful as an active ingredient of anti-tumor agents, etc.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: October 31, 1989
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Chikara Murakata, Akira Sato, Masaji Kasai, Eiji Kobayashi, Makoto Morimoto, Shiro Akinaga