Abstract: A process for producing a spherical chelating resin is disclosed. In the production, a prepolymer is prepared in the absence or presence of a solvent by subjecting a poly-N-substituted polyamine having at least two residual active hydrogen atoms bonded to nitrogen atoms or a poly-N-substituted polyalkylene imine having at least two residual active hydrogen atoms bonded to nitrogen atoms to a poly-addition reaction with an epoxy compound having at least two epoxy groups. The prepolymer is cured by heating and agitating a suspension of the prepolymer in an aqueous solution of a water-soluble high polymer or a nonionic surfactant in the absence or presence of known curing agents for epoxy resins. The resulting spherical cured resin is subjected to a saponification reaction or to a reaction with a hydrazine or a polyamine, and then a spherical chelating resin is obtained.