Abstract: Triazaspiro[5.5]undecane derivatives, quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as an active ingredient.

Abstract: Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein R1 is formula (II) or formula (III); R2 is alkyl or alkynyl etc.; R3, R4 is H, (substituted) alkyl etc., or R3 and R4 together to form formula (IV); R5 is H or alkyl).

Abstract: The present invention relates to a medicament for preventing and/or treating HIV infectious diseases comprising a compound of formula (J) as active ingredient and glucopyranose derivative of formula (W) or non-toxic salts thereof (the symbols in the formula are as described in the specification).

Abstract: A novel human polypeptide, the method for prepareation thereof, a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA, a replication or expression plasmid containing the cDNA integrated thereinto, a host cell transformed with plasmid, an antibody against the polypeptide and a pharmaceutical composition containing the polypeptide or the antibody.

Abstract: Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or expression plasmids having the cDNAs integrated thereinto; host cells transformed by the plasmids; antibodies against the above polypeptides; and medicinal compositions containing the peptides or the antibodies.

Abstract: A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it. The polypeptides of the present invention possess hematopoiesis regulating activity, tissue generation/regeneration activity, activin/inhibin activity, chemotactic/chemokinetic activity, hemostatic and thrombolytic activity, and receptor/ligand activity, therefore, they are expected to be useful for prevention and/or treatment of various diseases.

Abstract: A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.

Abstract: A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it.

Abstract: The present invention is related to novel polypeptide consisting of 205 amino acids which is produced in an endothelial cell line of human umbilical cord vein, a method of producing it, DNA encoding the polypeptide, a vector comprising the DNA, host cells transformed or transfected with the vector, an antibody to the polypeptide and pharmaceutical composition containing the polypeptide or antibody. The polypeptide of the present invention may be useful as itself or secretion type for the prevention of or in treatment of immune diseases caused by adhesion of platelet, many kind of leukocytes and macrophage and disease relating to thrombus formation (e.g. rheumatoid arthritic, allergy, arteriosclerosis, rejection after an internal organ plantation, myocardial infarction, brain infraction or reperfusion failure caused by it, DIC and septicemia etc.), or for screening test of the prevention of and/or in treatment of the above disease.

Abstract: A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.