Abstract: The invention discloses a graphene composite film modified by single crystal sapphire whiskers as well as a preparation method and application thereof. The graphene composite film provided by the invention comprises graphene and single crystal sapphire whiskers, the single crystal sapphire whiskers and the graphene are dispersed in the graphene composite film, and the content by weight of the graphene is greater than that of the single crystal sapphire whiskers. The graphene composite film can be used to prepare an electrode and applied to lithium ion batteries and capacitors. The graphene composite film has excellent toughness, structural stability and folding resistance as well as excellent electroconductivity and thermoconductivity; and the preparation method thereof is good in reproducibility and low in cost.

Abstract: A ceramic-based toughness-enhanced material includes the following starting materials by volume percentage: 92-96% ceramic substrate powder, 2-4% single crystal sapphire fiber, 0.3-0.4% ceramic substrate disperser, 0.6-0.7% single crystal sapphire fiber disperser and 3-5% sintering aid.

Abstract: A interply hybrid composite based single crystal alpha-aluminium oxide fiber includes single crystal alpha-aluminium oxide fiber, glass fiber and a resin compatibilizer; a hybrid ratio of the single crystal alpha-aluminium oxide fiber to the glass fiber is 1:40 to 3:53.

Abstract: The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates.

Abstract: The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates.

Abstract: The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates.

Abstract: The present invention relates to an active targeted water-solubility macromolecule polymer, conjugate with interferon and pharmaceutical composition comprising the conjugate. The targeted agent includes, for example, glucose, galatose and the like, as well as their derivates. The conjugate of the present invention is well in water-solubility and have long physiological cycle half-life period, and have specific recognition to pathology organize, improved and increased medication effect of interferon to Hepatitis B, Hepatitis C etc. infectivity sickness and cancer, infect complication etc.

Abstract: The present invention relates to a conjugate of hydrophilic polymer-multicarboxyl oligopeptide and drug molecule of the following formula: wherein: P is a hydrophilic polymer; m is an integer of 2˜12; j is an integer of 1˜6; Ri is a group selected from H, C1-12 alkyl, substituted aryl, aralkyl, heteroalkyl and substituted alkyl; X and Z are linking groups; and TA is drug molecule. The conjugate has low toxicity and an ability to carry more than one drug molecule to improve solubility, sustain and control drug release, and has a remarkably enhancing effect especially to antitumor drug such as paclitaxel and camptothecin etc.

Abstract: The present invention relates to a group of conjugates of the hydrophilic polymers and the molecules from boxwood extraction. PEGylation process or the process alike was used to generate the conjugates, which have increased water solubility and prolonged the circulation half-life in the body.

Abstract: The present invention relates to an active targeted water-solubility macromolecule polymer, conjugate With interferon and pharmaceutical composition comprising the conjugate. The targeted agent includes, for example, glucose, galatose and the like, as well as their derivates. The conjugate of the present invention is well in water-solubility and havc long physiological cycle half-life period, and have specific recognition to pathology organize, improved and increased medication effect of interferon to Hepatitis B, Hepatitis C etc. infectivity sickness and cancer, infect complication etc.

Abstract: The present invention discloses conjugates of polyethylene glycol and flavone or flavonoid drugs. The conjugates are formed by attaching PEG to the flavone derivatives such as puerarin, daidzein, baicalein and baicalin to improve their water solubility and circulation half-lives in the body. Because PEG is non-toxic and non-immunogenic, PEG conjugated drug molecules will have better therapeutic effects and convenience in administration.

Abstract: The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates.

Abstract: The present invention relates to a conjugate of hydrophilic polymer-multicarboxyl oligopeptide and drug molecule of the following formula: wherein: P is a water soluble polymer; m is an integer of 2˜12; j is an integer of 1˜6; Ri is a group selected from H, C1-12 alkyl, substituted aryl, aralkyl, heteroalkyl and substituted alkyl; X and Z are linking groups; and TA is drug molecule. The conjugate has low toxicity and an ability to carry more than one drug molecule to improve solubility, sustain and control drug release, and has a remarkably enhancing effect especially to antitumor drug such as paclitaxel and camptothecin etc.