Patents by Inventor Shiu-Ru Lin
Shiu-Ru Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170306411Abstract: The present invention improves the material of a CRC detection chip and the gene labeling, hybridization, reaction formula, and reaction time. Thus, physicians can clinically track and assess treatment plans for CRC patients and for various further treatments. The sensitivity and specificity of the CRC detection are improved with higher effectiveness than the traditional CEA detection.Type: ApplicationFiled: April 11, 2017Publication date: October 26, 2017Inventors: Chang-Han Wu, Fu-Yen Chung, Shiu-Ru Lin, Chi-Kai Yang
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Patent number: 9181581Abstract: A method of diagnosing a sample with an automated genechip array for a fast diagnosis having high accuracy, where the sample is processed through lysis, separation, purification, labeling, reacting in the genechip array, taking a photo thereafter and analyzing the photo.Type: GrantFiled: March 26, 2014Date of Patent: November 10, 2015Assignee: FOOYIN UNIVERSITY HOSPITALInventors: Shiu-Ru Lin, Hui-Jen Chang, Suz-Kai Hsiung, Chan-Han Wu
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Patent number: 9012147Abstract: A gene chip is provided for detection. When used on clinical detection, the gene chip directly detects blood without magnification. Gene expressions are examined with high sensitivity and convenience simultaneously.Type: GrantFiled: May 31, 2013Date of Patent: April 21, 2015Assignees: CaryGene Biotechnology Corp., Fooyin University HospitalInventors: Chan-Han Wu, Shiu-Ru Lin, Hsueh-Chiao Liu
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Publication number: 20140206571Abstract: A method of diagnosing a sample with an automated genechip array for a fast diagnosis having high accuracy, where the sample is processed through lysis, separation, purification, labeling, reacting in the genechip array, taking a photo thereafter and analyzing the photo.Type: ApplicationFiled: March 26, 2014Publication date: July 24, 2014Applicant: Fooyin University HospitalInventors: Shiu-Ru Lin, Hui-Jen Chang, Suz-Kai Hsiung, Chan-Han Wu
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Publication number: 20140147841Abstract: A gene chip is provided for detection. When used on clinical detection, the gene chip directly detects blood without magnification. Gene expressions are examined with high sensitivity and convenience simultaneously.Type: ApplicationFiled: May 31, 2013Publication date: May 29, 2014Inventors: Chan-Han Wu, Shiu-Ru Lin, Hsueh-Chiao Liu
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Publication number: 20140080723Abstract: A method is provided for fast diagnosis of tubercle bacillus (TB). The method can be used for efficacy test at the same time. 13 specific TB genes and 6 drug-resistance genes are selected. Those genes are formed into a construction for diagnosing tuberculosis and testing drug resistance simultaneously.Type: ApplicationFiled: May 31, 2013Publication date: March 20, 2014Inventors: Fu-Yen Chung, Shiu-Ru Lin, Hui-Jen Chang, Ia-Tang Huang
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Patent number: 8309344Abstract: The present invention is applied in fields like biological medicine and tissue engineering. A fluid control system in a cell isolation and culture system is used to automatically process sample preparation, circulating tumor cell (CTC) isolation, plate changing and cell culturing. By using the present invention, time and labor are saved; moreover, the present invention has a small size and is easily carried.Type: GrantFiled: October 13, 2009Date of Patent: November 13, 2012Assignee: Fooyin University HospitalInventors: Hui-Jen Chang, Shiu-Ru Lin, Chun-Hung Lee, Der-And Tsao
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Patent number: 8178343Abstract: A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a fast, accurate, sensitive and cheap WEnCA-Chipball platform is provided for mass analysis and automatic operation while human error and time for diagnosis are both reduced.Type: GrantFiled: August 9, 2010Date of Patent: May 15, 2012Assignee: Fooyin University HospitalInventors: Shiu-Ru Lin, Hui-Jen Chang, Der-An Tsao
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Publication number: 20110281774Abstract: A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a fast, accurate, sensitive and cheap WEnCA-Chipball platform is provided for mass analysis and automatic operation while human error and time for diagnosis are both reduced.Type: ApplicationFiled: August 9, 2010Publication date: November 17, 2011Applicant: FOOYIN UNIVERSITY HOSPITALInventors: Shiu-Ru Lin, Hui-Jen Chang, Der-An Tsao
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Publication number: 20110281770Abstract: A sample is diagnosed with a genechip array by the present disclosure. The sample is automatically diagnosed by devices revealed in the present disclosure for a fast diagnosis having high accuracy.Type: ApplicationFiled: August 3, 2010Publication date: November 17, 2011Applicant: FOOYIN UNIVERSITY HOSPITALInventors: Shiu-Ru Lin, Hui-Jen Chang, Suz-Kai Hsiung, Chan-Han Wu
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Publication number: 20110177961Abstract: The present disclosure diagnoses mycobacterium tuberculosis, not mycobacterium tuberculosis complex only. Specific target genes are selected from regions of difference of mycobacterium tuberculosis. After hybridization with labeling substances, sputum samples are processed through color developments separately for obtaining images to be analyzed automatically. Thus, the present disclosure rapidly diagnoses mycobacterium tuberculosis in the sputum samples with a simple operation and a low cost.Type: ApplicationFiled: January 15, 2010Publication date: July 21, 2011Applicants: Fooyin University, Institute for Biotechnology and Medicine IndustryInventors: Shiu-Ru Lin, Ching-Sheng Yeh, Chia-Sui Sun, Jong-Rung Tsai, Ming-Je Yang
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Publication number: 20110059519Abstract: The present invention is apllied in fields like biological medicine and tissue engineering. A fluid control system in a cell isolation and culture system is used to automatically process sample preparation, circulating tumor cell (CTC) isolation, plate changing and cell culturing. By using the present invention, time and labor are saved; moreover, the present invention has a small size and is easily carried.Type: ApplicationFiled: October 13, 2009Publication date: March 10, 2011Applicant: Fooyin University HospitaInventors: Hui-Jen Chang, Shiu-Ru Lin, Chun-Hung Lee, Der-An Tsao
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Publication number: 20100184623Abstract: A gene-array operation chip device includes a reaction chamber, and a plurality of inlet holes connected respectively to agitation channels for creating agitation currents within the reaction chamber. Each agitation channel has two ends respectively connected to one of the inlet holes and to the reaction chamber. The agitation channels are inclined with respect to radial directions about an axis of the reaction chamber. Preferably, a flow channel interconnecting two reaction chambers has a hydrophobic wall surface to limit a fluid from flowing naturally between the chambers. In an embodiment, the reaction chamber is a hybridization chamber provided with a membrane-array.Type: ApplicationFiled: January 22, 2009Publication date: July 22, 2010Inventors: Suz-Kai HSIUNG, Shiu-Ru LIN, Hui-Jen CHANG
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Publication number: 20100130379Abstract: A gene chip for chemiluminescent detection is obtained. The chip uses multiple markers. Weighted scores are given to genes separately according to their influences on forming a cancer. The present invention provides an objective and accurate disease assistant diagnosis with a low cost, a high sensitivity and a good performance. The present invention can be widely applied to personal medical behaviors, like clinical diagnosis, treatment filtration, prognosis review, preventive medicine, etc.Type: ApplicationFiled: October 23, 2009Publication date: May 27, 2010Applicant: FOOYIN UNIVERSITYInventors: Shiu-Ru Lin, Chung-Chi Chen
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Patent number: 7575928Abstract: This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of intestines and colorectal cancer tissue; (2) collecting genes with highly differential gene expression by Suppression Subtractive Hybridization (SSH), and building library; (3) deriving colonies with relatively high signal intensities from cancer tissue; (4) collecting more clinically cancer tissues by Northern Hybridization, real-time Polymerase Chain Reaction (PCR) combined with analysis of bioinformation to affirm variation between differential gene expression; and (5) selecting the most suitable genes from said library, and using the gene sequence as reagent provides the effects of early diagnosis, specificity, highly sensitivity and safety.Type: GrantFiled: February 26, 2004Date of Patent: August 18, 2009Assignee: Kaohsiung Medical UniversityInventors: Shiu-Ru Lin, Jaw-Yuan Wang
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Publication number: 20080050729Abstract: A method for detecting cancer cells. A chemical luminescence reaction is used to obtain a result image. The result image is analyzed through a weighting process to a value of each gene. By doing do, a cancer can be precisely diagnosed.Type: ApplicationFiled: October 25, 2006Publication date: February 28, 2008Applicant: Kaohsiung Medical UniversityInventors: Shiu-Ru Lin, Tian-Lu Cheng
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Publication number: 20060068396Abstract: The present invention is a method for a biochip detecting limited cells. The present invention comprises steps of: obtaining a nylon membrane chip having required nucleotide fragments arranged in a dot matrix way by using a manual spotter; naturally drying by heat and fixing the nucleotide fragments on the nylon membrane chip by a rapid nucleic acid cross-linker when preparing a chip; collecting some normal whole blood to be linearly amplified; synthesizing required amount of cDNA by a reverse transcription to obtain a marker as a probe; processing labeling, hybridization and post-hybridization to the chip and the marker; processing chemical color reaction; and automatically analyzing the result image after the chemical color reaction. Accordingly, a gene biochip operation technology platform with low cost, easy operation and high efficiency is obtained.Type: ApplicationFiled: September 24, 2004Publication date: March 30, 2006Inventors: Shiu-Ru Lin, Tian-Lu Cheng, Yi-Fang Chen, Chan-Han Wu
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Publication number: 20050191634Abstract: This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of intestines and colorectal cancer tissue; (2) collecting genes with highly differential gene expression by Suppression Subtractive Hybridization (SSH), and building library; (3) deriving colonies with relatively high signal intensities from cancer tissue; (4) collecting more clinically cancer tissues by Northern Hybridization, real-time Polymerase Chain Reaction (PCR) combined with analysis of bioinformation to affirm variation between differential gene expression; and (5) selecting the most suitable genes from said library, and using the gene sequence as reagent provides the effects of early diagnosis, specificity, highly sensitivity and safety.Type: ApplicationFiled: February 26, 2004Publication date: September 1, 2005Inventors: Shiu-Ru Lin, Jaw-Yuan Wang