Abstract: An in vitro method for detecting presence of cancer includes obtaining a single hair sample. An x-ray beam is emitted from a source towards the hair sample. A small angle X-ray scattering (SAXS) intensity profile is generated after the x-ray beam hits the hair sample. The SAXS profile is received on a detector to obtain SAXS data, which is desmeared and Kratky Analysis is performed. A relative estimation of peak area under 1.38 nm?1 to 0.89 nm?1 from keratin and lipid content in the hair sample is performed to obtain R and is corrected by dividing by D, thickness of the hair. R? is computed using formula: 10×R2/(D?R). The value of R? is compared with clinically validated samples. If R? value is below 0.7, it indicates the presence of cancer and if it is above 0.8, it indicates absence of cancer.

Abstract: The present application provides an in vitro method for detecting presence of cancer by analyzing small angle X-ray scattering (SAXS) of a single hair by automated data analysis using end user or in-house X-ray source. Specifically, the present methodology provides a method which also provides steps to allow correction for hair thickness and provide a quantitative view on the cancer status of the subject.

Abstract: Various embodiments of systems and methods for query optimization based on reporting specifications are described herein. A plurality of data provider objects are categorized into one or more used data provider objects that are used in a report at a first instance and one or more unused data provider objects that are not used in the report at the first instance. The plurality of data provider objects is part of a query. A modified query is then created by excluding the unused data provider objects. Data of the used data provider objects is retrieved and stored in a local data source using the modified query. The unused data provider objects are displayed such that they are differentiated from the used data provider objects and can be selected for use in the report at the second instance.