Abstract: A computer system and computer-implemented method for receiving digitally stored metadata that defines a digital offer including specifying one or more static components and one or more dynamic components; for each of the static components, pre-computing a digital image in an interim raw byte representation and digitally storing the interim raw byte representations corresponding to all the static components; in response to receiving a request to provide a digital offer in real-time on demand: retrieving the interim raw byte representations corresponding to all the static components; for each of the dynamic components, rendering a component image file in real-time on demand; joining the interim raw byte representations corresponding to all the static components and all the component image files corresponding to the dynamic components and creating and storing a single digital image file corresponding to the digital offer; and transmitting the single digital image file to another computer.

Abstract: The invention relates to ketolide compounds of Formula (1) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R, is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R, is hydrogen, R3 is fluorine.

Abstract: The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.

Abstract: The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.

Abstract: The reconstruction of garbage collection information corresponding to an application. Upon accessing a portion of compiler generated application code, a computing system generates computational results that identifies one or more program state storage locations that track live references or memory pointers that can be displaced during garbage collection. This may be performed for multiple application code portions (such as methods or functions of an application), and may be performed just before garbage collection. To generate the computational results, the application code portion may first be subjected to a liveness analysis to generate liveness analysis results in the form of one or more live program state storage locations in the application code portion. The computational results may then be generated using the liveness analysis results and type information from a type service to provide the set of storage locations referencing live memory objects.

Abstract: The reconstruction of garbage collection information corresponding to an application. Upon accessing a portion of compiler generated application code, a computing system generates computational results that identifies one or more program state storage locations that track live references or memory pointers that can be displaced during garbage collection. This may be performed for multiple application code portions (such as methods or functions of an application), and may be performed just before garbage collection. To generate the computational results, the application code portion may first be subjected to a liveness analysis to generate liveness analysis results in the form of one or more live program state storage locations in the application code portion. The computational results may then be generated using the liveness analysis results and type information from a type service to provide the set of storage locations referencing live memory objects.