Patents by Inventor Shivakumar Selvaraj
Shivakumar Selvaraj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230384741Abstract: The present invention relates to a computer implemented method (600) for optimization of a bioprocessing system (100) formed by interconnected or interconnectable bioprocessing units and configured to provide a desired system functionality, the method comprising obtaining (610) requirement data of a bioprocess, the requirement data being at least indicative of the desired system functionality, and indicative of a desired substance resulting from the operation of the bioprocess system, obtaining (620) unit data indicative of characteristics of a plurality of bioprocessing units, generating (630) at least one optimized or suitable bioprocessing system configuration capable to provide the desired system functionality, the bioprocessing system configuration comprising a selection of bioprocessing units from the plurality of bioprocessing units selected using the requirement data, the unit data and an objective function dependent on the requirement data and the unit data.Type: ApplicationFiled: June 1, 2023Publication date: November 30, 2023Inventors: Mikael Johansson, Pasi Juntikka, Peter Toreheim, Shivakumar Selvaraj
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Publication number: 20230250380Abstract: A component management apparatus for a bioprocessing system includes a frame having a plurality of segments, including at least a first segment and a second segment pivotably connected to the first segment such that at least the second segment is movable between a closed position and an open position, and at least one mounting bracket connected to the frame for connection of a bioprocess component.Type: ApplicationFiled: July 8, 2021Publication date: August 10, 2023Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ELIZABETH STEGNER, KANDAKUMAR MURUGESAN, SAIRAM CHERUNNI, MANAS DASH, PRASAD BAGIYANATHAN, SHIVAKUMAR SELVARAJ, BINEESH KANDOTH, NITYANANDA MAIYA, NICHOLAS BROCATO, CHANDRA PRAKASH DHANARIYA, SURESH SUNDARAMOORTHY
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Patent number: 11717790Abstract: A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).Type: GrantFiled: June 20, 2019Date of Patent: August 8, 2023Assignee: CYTIVA SWEDEN ABInventors: Nityananda Maiya, Deepak Aravind, Fredrik Lundström, Saameera Simha Hindupur, Shivakumar Selvaraj, Alagur Sahebagouda
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Patent number: 11714387Abstract: The present invention relates to a computer implemented method (600) for optimization of a bioprocessing system (100) formed by interconnected or interconnectable bioprocessing units and configured to provide a desired system functionality, the method comprising obtaining (610) requirement data of a bioprocess, the requirement data being at least indicative of the desired system functionality, and indicative of a desired substance resulting from the operation of the bioprocess system, obtaining (620) unit data indicative of characteristics of a plurality of bioprocessing units, generating (630) at least one optimized or suitable bioprocessing system configuration capable to provide the desired system functionality, the bioprocessing system configuration comprising a selection of bioprocessing units from the plurality of bioprocessing units selected using the requirement data, the unit data and an objective function dependent on the requirement data and the unit data.Type: GrantFiled: August 30, 2019Date of Patent: August 1, 2023Assignee: Cytiva Sweden ABInventors: Mikael Johansson, Pasi Juntikka, Peter Toreheim, Shivakumar Selvaraj
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Publication number: 20230193188Abstract: A bioprocessing system (100, 200) including a storage unit (102, 202) for storing a feed fluid (103, 203), a filter (106, 206) coupled to the storage unit (102, 202) via a feed path (104, 204), and a feed pump (114, 212) coupled to the feed path (104, 204). The bioprocessing system (100, 200) further includes a collection unit (102, 216) coupled to the filter (106, 206) via a downstream path (118, 218) and a turbidity sensor (134, 224) coupled to the downstream path (118, 218). Furthermore, the bioprocessing system (100, 200) includes a processing unit (136, 226) configured to receive an output from the turbidity sensor (134, 224) and determine a concentration of a product in a filtration fluid (121, 222) based on the output. The processing unit (136, 226) is further configured to monitor an operating condition of the filter (106, 206) on-line based on concentration of the product.Type: ApplicationFiled: June 24, 2021Publication date: June 22, 2023Inventors: Shivakumar SELVARAJ, Sahebagouda ALAGUR, Sameera Simha HINDUPUR, Nityananda MAIYA, Mayank DADHWAL, Fredrik LUNDSTROM
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Publication number: 20220403318Abstract: The present subject matter discloses a bioreactor apparatus. The bioreactor apparatus comprises a bioreactor vessel configured to culture cells. The bioreactor apparatus furthermore comprises a sensor configured to measure Dissolved Oxygen (DO) in the bioreactor vessel. The DO measurements comprise a plurality of DO values recorded at, at least, a plurality of time instances during operation of the bioreactor apparatus. The bioreactor apparatus furthermore comprises a controller configured to obtain the DO measurements. The controller furthermore is to determine, in real-time or approximately real-time, an oxygen mass transfer co-efficient (kLa) associated with the operation of the bioreactor apparatus. Furthermore, the controller is configured to control, in real-time or approximately real-time, at least one cell culture parameter associated with the operation of the bioreactor apparatus based on the kLa.Type: ApplicationFiled: October 1, 2020Publication date: December 22, 2022Inventors: Shivakumar Selvaraj, Bineesh Kandoth, Sahebagouda Alagur, Nagaraj Raghavendra Rao, Thomas Falkman
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Publication number: 20210263482Abstract: The present invention relates to a computer implemented method (600) for optimization of a bioprocessing system (100) formed by interconnected or interconnectable bioprocessing units and configured to provide a desired system functionality, the method comprising obtaining (610) requirement data of a bioprocess, the requirement data being at least indicative of the desired system functionality, and indicative of a desired substance resulting from the operation of the bioprocess system, obtaining (620) unit data indicative of characteristics of a plurality of bioprocessing units, generating (630) at least one optimized or suitable bioprocessing system configuration capable to provide the desired system functionality, the bioprocessing system configuration comprising a selection of bioprocessing units from the plurality of bioprocessing units selected using the requirement data, the unit data and an objective function dependent on the requirement data and the unit data.Type: ApplicationFiled: August 30, 2019Publication date: August 26, 2021Inventors: Mikael Johansson, Pasi Juntikka, Peter Toreheim, Shivakumar Selvaraj
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Publication number: 20210260530Abstract: A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).Type: ApplicationFiled: June 20, 2019Publication date: August 26, 2021Inventors: Nityananda Maiya, Deepak Aravind, Fredrik Lundström, Saameera Simha Hindupur, Shivakumar Selvaraj, Alagur Sahebagouda