Abstract: A method of providing a refractive prescription includes: receiving a plurality of images from a sensor, the plurality of images captured sequentially using light from an eye of a living being: determining respective values of an image quality metric (IQM) for respective images of the captured plurality of images: selecting a subset of the plurality of images based on the values of the IQM; and determining and outputting to a user a refractive prescription for the eye based on the subset of the plurality of images. Example embodiments can be employed to produce and output better refractive prescriptions by taking into account dynamics of a patient's eye.

Abstract: Open view smart eyewear is combined with a wavefront aberrometer module. The smart eyewear serves as an open view eyewear form factor and house the wavefront aberrometer module among other digital processing components and corresponding software. Alternatively, the wavefront aberrometer module is removably coupled to the smart eyewear. The wavefront aberrometer module calibrates a tunable optical element according to detected optical needs of the user. The wavefront aberrometer module automatically adjusts the wearer-user's effective visual acuity (at least refractive power) viewing through the smart eyewear. The smart eyewear apparatus can also provide clinical-quality optical measurements of wearer-users for electronic communication or transmission to an eye care professional. Alignment of open view smart eyewear, the wavefront aberrometer module, and user's eyes (line of sight) can be facilitated.

Abstract: Clinical-quality eye examinations are provided at locations remote from the physician and outside of a clinical setting. A portable optical device and corresponding software are delivered to the patient's location. The portable optical device is configured for patient use in self-conducting an eye or vision exam and taking optical measurements. As a function of type of optical measurement data or health consideration of the patient, the corresponding software provides uploading and live streaming of the optical measurement data to the physician. The corresponding software is executed during the patient conducting the eye (vision) exam and enables the remotely located physician, to participate in the same via video conference. Alternatively, an artificial intelligence resource operating remotely or locally can provide physician-type guidance and eye health assessments. Alignment of device and patient eyes can be facilitated for remote exams.

Abstract: An apparatus, and corresponding method, for determining a property of an eye includes a housing with a proximal port that receives an eye and also light from the eye. The housing further includes a distal port, and the two ports together form a visual channel providing an open view to enable the eye to see target indicia external to and spaced away from the housing. A wavefront sensor within the housing is configured to receive the light from the eye via the optical path and to measure a wavefront of the light. A determination module determines an objective refractive correction based on the wavefront and predicts a subjective refractive preference of a person having the eye based on the objective refractive correction. Embodiments can be handheld, and binocular, and predict subjective refraction based on demographic and other information.

Abstract: An apparatus, and corresponding method, for determining a refractive property of an eye includes a housing with a port configured to receive an eye and also light from the eye. A tunable lens can be mounted to the housing to apply a variable focal power to the light from the eye and to pass the light along an optical path toward a wavefront sensor within the housing. The wavefront sensor can receive the light via the optical path and measure a wavefront thereof. A determination module can be configured to determine a property of the eye based on the wavefront. Embodiments can be handheld, portable, and open view, while providing objective wavefront aberrometry, subjective phoroptry, and accommodation and presbyoptic evaluation, as well as lensometry functions.

Abstract: Method for distinguishing between red blood cells and white blood cells. The method includes obliquely illuminating the blood sample with light from at least two rotational angles and analyzing light side scattered from cells in the sample to provide accurate discrimination of white blood cell types based on the anisotropy of red blood cell side scatter as compared to more isotropic white blood cell side scatter.

Abstract: Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.

Abstract: High-contrast, high-density cell-sized microparticles are introduced into a cell-containing solution prior to the solution being spread onto a planar substrate for imaging. The microparticles facilitate both the process of imager autofocusing and the subsequent registration of multiple images taken of regions of the substrate. The microparticles can further facilitate the correction of chromatic aberration.

Abstract: An apparatus, and corresponding method, for determining a refractive property of an eye includes a housing with a port configured to receive an eye and also light from the eye. A tunable lens can be mounted to the housing to apply a variable focal power to the light from the eye and to pass the light along an optical path toward a wavefront sensor within the housing. The wavefront sensor can receive the light via the optical path and measure a wavefront thereof. A determination module can be configured to determine a property of the eye based on the wavefront. Embodiments can be handheld, portable, and open view, while providing objective wavefront aberrometry, subjective phoroptry, and accommodation and presbyoptic evaluation, as well as lensometry functions.

Abstract: A method and system for acquiring a series of medical images includes acquiring imaging data, identifying double coincidence events and multiple detection (MD) coincidence events from the imaging data, and storing the double coincidence events and the MD coincidence events in a first dataset and a second dataset, respectively. The method also includes applying a normalization correction to the first dataset and/or the second dataset using normalization values based on double coincidence events and/or MD coincidence events to obtain at least one normalized dataset, and reconstructing a series of medical images of the subject from the at least one normalized dataset.

Abstract: An apparatus, and corresponding method, for determining a refractive property of an eye includes a housing with a port configured to receive an eye and also light from the eye. A tunable lens can be mounted to the housing to apply a variable focal power to the light from the eye and to pass the light along an optical path toward a wavefront sensor within the housing. The wavefront sensor can receive the light via the optical path and measure a wavefront thereof. A determination module can be configured to determine a property of the eye based on the wavefront. Embodiments can be handheld, portable, and open view, while providing objective wavefront aberrometry, subjective phoroptry, and accommodation and presbyoptic evaluation, as well as lensometry functions.

Abstract: A method and system for acquiring a series of medical images includes receiving medical imaging data corresponding to photons emitted from a subject having received a dose of a radiotracer. Determining, from the medical imaging data, coincidence events including photon coincidence events involving two photons and photon coincidence events involving more than two photons. The photon coincidence events involving two photons and photon coincidence events involving more than two photons are processed and use to reconstruct a series of medical images of the subject.

Abstract: Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.

Abstract: Non-uniformities in substrate thickness and surface topography contribute significantly to the need for auto-focusing on a sample deposited thereon. These auto-focusing needs can be reduced or eliminated by measuring and storing substrate surface topography for later retrieval by an imaging system that can use the topographic information to help set appropriate focal parameters. These steps can be done in advance of an imaging experiment to reduce focus-related delays during the experiment. Topographic information can be stored, for example, in a database, associated with a representation of a unique substrate identifier; entry of the representation retrieves the topographic information. As another example, topographic information can be stored in an encoding device associated with the substrate.

Abstract: Among other aspects, the present invention provides for the deposition of biological particles, such as cells, in a liquid, in a desired two-dimensional pattern on a planar surface of a substrate so as to permit rapid, simple, and sensitive detection of cells and/or sub-cellular components (e.g., proteins, biomarkers) disposed on the substrate. In various aspects, the systems and methods can enable reproducible high-throughput screening and/or allow for sensitive and specific detection of rare events in heterogeneous cell populations within a biological sample, with limited or no selective cell loss or sample enrichment.

Abstract: A method and system for acquiring a series of medical images includes a plurality of detectors configured to be arranged to acquire gamma rays emitted from a subject as a result of an advanced radionuclide administered to the subject and communicate signals corresponding to acquired gamma rays. A data processing system is configured to receive the signals from the plurality of detectors, determine double coincidence event dataset and a multiple coincidence event dataset, separate the multiple coincidence event dataset into at least one of a standard lines of response dataset and a nonstandard lines of response dataset, and apply a background correction to the double coincidence event dataset based on the non-standard lines of response dataset and/or the standard lines of response dataset to obtain a standard coincidence dataset.

Abstract: High-contrast, high-density cell-sized microparticles are introduced into a cell-containing solution prior to the solution being spread onto a planar substrate for imaging. The microparticles facilitate both the process of imager autofocusing and the subsequent registration of multiple images taken of regions of the substrate. The microparticles can further facilitate the correction of chromatic aberration.

Abstract: Method for distinguishing between red blood cells and white blood cells. The method includes obliquely illuminating the blood sample with light from at least two rotational angles and analyzing light side scattered from cells in the sample to provide accurate discrimination of white blood cell types based on the anisotropy of red blood cell side scatter as compared to more isotropic white blood cell side scatter.

Abstract: Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.

Abstract: Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.