Abstract: The present invention relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is a mTOR inhibitor or a pharmaceutically acceptable salt thereof.

Abstract: A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.

Abstract: Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.

Abstract: Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.

Abstract: A method and system for acquiring a series of medical images includes acquiring imaging data, identifying double coincidence events and multiple detection (MD) co-incidence events from the imaging data, and storing the double coincidence events and the MD coincidence events in a first dataset and a second dataset, respectively. The method also includes applying a normalization correction to the first dataset and/or the second dataset using normalization values based on double coincidence events and/or MD coincidence events to obtain at least one normalized dataset, and reconstructing a series of medical images of the subject from the at least one normalized dataset.

Abstract: Among other aspects, the present invention provides for the deposition of biological particles, such as cells, in a liquid, in a desired two-dimensional pattern on a planar surface of a substrate so as to permit rapid, simple, and sensitive detection of cells and/or sub-cellular components (e.g., proteins, biomarkers) disposed on the substrate. In various aspects, the systems and methods can enable reproducible high-throughput screening and/or allow for sensitive and specific detection of rare events in heterogeneous cell populations within a biological sample, with limited or no selective cell loss or sample enrichment.

Abstract: A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.

Abstract: A combination of a CDK4/6 inhibitor and an mTOR inhibitor for the treatment of cancer.

Abstract: A combination of a CDK4/6 inhibitor and a MEK inhibitor for the treatment of diseases such as cancer.

Abstract: The present invention relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is a mTOR inhibitor or a pharmaceutically acceptable salt thereof.

Abstract: A method and system for acquiring a series of medical images includes receiving medical imaging data corresponding to photons emitted from a subject having received a dose of a radiotracer. Determining, from the medical imaging data, coincidence events including photon coincidence events involving two photons and photon coincidence events involving more than two photons. The photon coincidence events involving two photons and photon coincidence events involving more than two photons are processed and use to reconstruct a series of medical images of the subject.

Abstract: High-contrast, high-density cell-sized microparticles are introduced into a cell-containing solution prior to the solution being spread onto a planar substrate for imaging. The microparticles facilitate both the process of imager autofocusing and the subsequent registration of multiple images taken of regions of the substrate. The microparticles can further facilitate the correction of chromatic aberration.

Abstract: A combination of a CDK4/6 inhibitor and an FGFR kinase inhibitor for the treatment of cancer.

Abstract: A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.

Abstract: A combination of a CDK4/8 inhibitor and an mTOR inhibitor for the treatment of cancer.

Abstract: A method of indexing images contained in scanned documents, wherein said scanned documents are stored in a repository, includes: for each document to be stored in the repository, dividing the document into a plurality of sections; scanning the plurality of sections; segmenting each scanned segment according to a predetermined coding model into image segment and non-image segments; associating each of the image segments with the document; and generating an index correlating the image segments with the document. The method may further include, at the time of image recall, displaying the index of image segments in a user interface; and responsive to selection of an image segment from the index, displaying the document information associated with the image segment in the user interface.

Abstract: A method of indexing images contained in scanned documents, wherein said scanned documents are stored in a repository, includes: for each document to be stored in the repository, dividing the document into a plurality of sections; scanning the plurality of sections; segmenting each scanned segment according to a predetermined coding model into image segment and non-image segments; associating each of the image segments with the document; and generating an index correlating the image segments with the document. The method may further include, at the time of image recall, displaying the index of image segments in a user interface; and responsive to selection of an image segment from the index, displaying the document information associated with the image segment in the user interface.

Abstract: A method of indexing images contained in scanned documents, wherein said scanned documents are stored in a repository, includes: for each document to be stored in the repository, dividing the document into a plurality of sections; scanning the plurality of sections; segmenting each scanned segment according to a predetermined coding model into image segment and non-image segments; associating each of the image segments with the document; and generating an index correlating the image segments with the document. The method may further include, at the time of image recall, displaying the index of image segments in a user interface; and responsive to selection of an image segment from the index, displaying the document information associated with the image segment in the user interface.

Abstract: A method of indexing images contained in scanned documents, wherein said scanned documents are stored in a repository, includes: for each document to be stored in the repository, dividing the document into a plurality of sections; scanning the plurality of sections; segmenting each scanned segment according to a predetermined coding model into image segment and non-image segments; associating each of the image segments with the document; and generating an index correlating the image segments with the document. The method may further include, at the time of image recall, displaying the index of image segments in a user interface; and responsive to selection of an image segment from the index, displaying the document information associated with the image segment in the user interface.