Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for system contextualization. For example, a method can include obtaining information pertaining to (i) parts of a manufacturing plant and (ii) steps of a process executing on the manufacturing plant; generating one or more virtual representations associated with each of the parts and the steps of the process; receiving a query from a user, the query being in conformation with a format of a hierarchical template model; and generating a response to the query based on the one or more virtual representations of the manufacturing plant.

Abstract: The present invention relates to the use of compositions and methods for treating or preventing a cancer condition in a subject. The use of composition comprises methods of treating or preventing cancer with agents that inhibit Hedgehog pathway activity. The pharmaceutical composition will further comprise agents that inhibit Smoothened receptor and/or Gli transcription in a subject.

Abstract: The present invention relates to the use of compositions for treating or preventing a cancer condition in a subject. The use of composition comprises methods of treating or preventing cancer with agents that inhibit TCF/LEF activity. The pharmaceutical composition will further comprise agents that inhibit TCF/LEF activity in a subject.

Abstract: The present invention relates to the use of compositions for treating or preventing a condition in a subject by inhibiting androgen signaling. The use of composition comprises methods of treating or preventing cancer with agents that inhibit androgen signaling. The pharmaceutical composition will further comprise agents that inhibit Androgen receptor activity, transcription, or expression in a subject.

Abstract: The present invention relates to the use of compositions for monitoring, diagnosis, detecting, and treating a cancer condition in a subject. The use of composition comprises methods of monitoring, diagnosis, and detecting cancer and inflammation with EN2 and/or SATB2 expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit EN2 and/or SATB2 expression or activity.

Abstract: The present invention relates to the use of compositions and methods for treating or preventing a cancer condition in a subject. The use of composition comprises methods of treating or preventing cancer with agents that inhibit Hedgehog pathway activity. The pharmaceutical composition will further comprise agents that inhibit Smoothened receptor and/or Gli transcription in a subject.

Abstract: The present invention relates to the use of compositions for treating or preventing a cancer condition in a subject. The use of composition comprises methods of treating or preventing cancer with agents that inhibit Nanog expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit Nanog expression or activity in a subject.

Abstract: The present invention relates to the field of cancer and inflammation, and in particular methods of monitoring, diagnosis, prognosis, detecting, treating and preventing cancer and inflammation conditions. The use of composition comprises method of monitoring, diagnosis, prognosis, and detecting cancer and inflammation with EN2 and/or SATB2 expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit EN2 and/or SATB2 expression or activity.

Abstract: The present invention relates to the field of cancer and inflammation, and in particular methods of monitoring, diagnosis, prognosis, detecting, treating and preventing cancer and inflammation conditions. The use of composition comprises method of monitoring, diagnosis, prognosis, and detecting cancer and inflammation with EN2 and/or SATB2 expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit EN2 and/or SATB2 expression or activity.

Abstract: The present invention relates to the field of cancer and inflammation, and in particular methods of monitoring, diagnosis, prognosis, detecting, treating and preventing cancer and inflammation conditions. The use of composition comprises method of monitoring, diagnosis, prognosis, and detecting cancer and inflammation with EN2 and/or SATB2 expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit EN2 and/or SATB2 expression or activity.