Abstract: This invention discloses methods and apparatus for modifying a silicone contact lens via laser ablation and a resulting modified lens. In some embodiments a lens is ablated in a hydrated state. A lens may also be ablated in an environment of decreased oxygen content.

Abstract: Various non-limiting embodiments disclosed herein relate to ophthalmic devices comprising photochromic materials having extended pi-conjugated systems. For example, various non-limiting embodiments disclosed herein provide a photochromic material, such as an indeno-fused naphthopyran, which comprises a group that extends the pi-conjugated system of the indeno-fused naphthopyran bonded at the 11-position of thereof. Further, the photochromic materials according to certain non-limiting embodiments disclosed herein may display hyperchromic absorption of electromagnetic radiation as compared to conventional photochromic materials and/or may have a closed-form absorption spectrum that is bathochromically shifted as compared to conventional photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.

Abstract: The present invention relates to a process comprising polymerizing via irradiation from a light source, a reaction mixture comprising at least one monomer and at least one photoinitiator wherein at least about 90% of incident light emitted by the light source is filtered to produce a soluble, high molecular weight polymer.

Abstract: The present invention relates to stabilized ophthalmic solutions comprising at least one peroxide. In one embodiment, the present invention relates to an ophthalmic solution comprising a pH between about 6 and about 8 and about 50 to about 1000 ppm hydrogen peroxide and about 0.005 wt % (50 ppm) to about 0.05 wt % (500 ppm) at least one salt of diethylenetriamine pentaacetic acid selected from the group consisting of calcium salts of diethylenetriamine pentaacetic acid, zinc salts of diethylenetriamine pentaacetic acid and mixed calcium/zinc salts of diethylenetriamine pentaacetic acid. The present invention further relates to a method for preserving ophthalmic solution comprising at least one peroxide.

Abstract: Methods of detecting the discharge and uptake rates of ophthalmic lenses containing pharmaceutical agents are disclosed herein.

Abstract: The present invention relates to a process comprising the steps of reacting a substituted epoxide, and preferably a silicone containing substituted epoxide with at least one lithium acrylic acid salt, at least one acrylic acid and optionally at least one inhibitor at a temperature above about 60° C. to form a substituted hydroxy acrylate.

Abstract: The present invention relates to a process for the purification of silicone containing compounds via supercritical fluid extraction. Specifically, the present invention relates to a process comprising the steps of contacting at least one silicone containing compound with a supercritical fluid having a density of between about 0.2 and about 0.8 g/ml, decreasing said density so that two phases are formed a first phase comprising said at least one silicone containing compound and a second phase comprising at least one impurity and separating said second phase from said first phase.

Abstract: This invention relates to antimicrobial polymeric articles containing metal salt particles having a particle size of less than about 200 nm dispersed throughout the polymer and methods for their production.

Abstract: Ophthalmic devices and methods of treating allergic conjunctivitis are disclosed herein.

Abstract: The present invention relates to biomedical devices, and particularly contact lenses comprising a polymer having entangled therein at least one acyclic polyamide.

Abstract: A packaging for an ophthalmic lens containing a pharmaceutical agent.

Abstract: The present invention relates to a process comprising the steps of reacting in the presence of a hydrosilylation catalyst, a first reaction mixture comprising a free radical reactive compound and a silicon containing compound to form a silicon substituted glyceryl (meth)acrylate.

Abstract: The present invention relates to compositions comprising omega-6 and/or omega-3 fatty acids and uses thereof. The present invention also relates to methods of treatment using such compositions.

Abstract: Ophthalmic compositions and methods of preparing such compositions are disclosed.

Abstract: The present invention relates to aqueous processes for the production of silicone hydrogel contact lenses.

Abstract: The present invention relates to polymer compositions formed from a reactive mixture comprising at least one substantially non-reactive prepolymer comprising silicone containing groups and compatibilizing groups and a hydrophilic component comprising at least one monomer capable of hydrogen bonding with said prepolymer.

Abstract: The present invention relates to a method comprising stabilizing, during autoclaving, an oxidatively unstable ophthalmic compound dissolved in an ophthalmic solution by incorporating a stabilizing effective amount of at least one electron rich polymer in said ophthalmic solution.

Abstract: This invention relates to a process for improving the stability of an ophthalmically compatible solution comprising at least one oxidatively unstable ophthalmic compound.

Abstract: The present invention relates to a process comprising exposing a polymerizable mixture comprising at least one lens forming component, at least one thermal initiator, at least one photoinitiator and at least one photochromic compound to device forming conditions comprising heat and actinic radiation to form a photochromic ophthalmic device.

Abstract: Various non-limiting embodiments disclosed herein relate to ophthalmic devices comprising photochromic materials having extended pi-conjugated systems. For example, various non-limiting embodiments disclosed herein provide a photochromic material, such as an indeno-fused naphthopyran, which comprises a group that extends the pi-conjugated system of the indeno-fused naphthopyran bonded at the 11-position of thereof. Further, the photochromic materials according to certain non-limiting embodiments disclosed herein may display hyperchromic absorption of electromagnetic radiation as compared to conventional photochromic materials and/or may have a closed-form absorption spectrum that is bathochromically shifted as compared to conventional photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.