Patents by Inventor Shivnath Sahebrao Patil

Shivnath Sahebrao Patil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of eribulin mesylate intermediate
    Patent number: 11447499
    Abstract: The present application provides improved processes for the synthesis of eribulin intermediate, which generally comprise the steps of: a) De-protecting the eribulin-enone (compound 1) in tetrahydrofuran by using TBAF solution, buffered with imidazole HCl in the presence of molecular sieve and sodium sulphate to get an insitu mixture of eribulin-dione diastereomer at C12 carbon (compound 2). Then ketalization may be performed of eribulin-dione insitu intermediate containing mixture of diastereomer at C12 carbon (compound 2) with PPTS in dichloromethane to yield eribulin-diol (compound 3).
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: September 20, 2022
    Assignee: RK PHARMA INC.
    Inventors: Ravishanker Kovi, Jayaraman Kannappan, Shivnath Sahebrao Patil
  • Polymorphs of ponatinib hydrochloride
    Patent number: 10221184
    Abstract: Novel crystalline ponatinib hydrochloride forms designated Form alpha and Form beta are disclosed. Form alpha is characterized by data selected from an XRPD pattern with peaks at about 6.5, 9.0, 12.25, 14.4, 16.70, 19.6, 22.2, 24.5, 28.2±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 1; and/or a combination thereof. Form beta is characterized by data selected from an XRPD pattern with peaks at about 10.7, 15.2, 15.8, 16.4 23.1, 25.0, 27.8±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 3; and/or combinations thereof. Processes for making Form alpha and Form beta are disclosed.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: March 5, 2019
    Assignee: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Ananda Babu Thirunavakarasu, Gaurav Yadav, Veerabhadra Rao Bobbili, Shivnath Sahebrao Patil, Sanjay F. Thakor
  • Novel polymorphs of ponatinib hydrochloride
    Publication number: 20180208599
    Abstract: Novel crystalline ponatinib hydrochloride forms designated Form alpha and Form beta are disclosed. Form alpha is characterized by data selected from an XRPD pattern with peaks at about 6.5, 9.0, 12.25, 14.4, 16.70, 19.6, 22.2, 24.5, 28.2±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 1; and/or a combination thereof. Form beta is characterized by data selected from an XRPD pattern with peaks at about 10.7,15.2, 15.8, 16.4 23.1, 25.0, 27.8±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 3; and/or combinations thereof. Processes for making Form alpha and Form beta are disclosed.
    Type: Application
    Filed: January 4, 2018
    Publication date: July 26, 2018
    Applicant: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Ananda Babu Thirunavakarasu, Gaurav Yadav, Veerabhadra Rao Bobbili, Shivnath Sahebrao Patil, Sanjay F. Thakor
  • Processes for making ponatinib and intermediates thereof
    Patent number: 9988389
    Abstract: Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 5, 2018
    Assignee: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik, Dhakhada Chetana Bharatbhai, Khichi Kuldip Fatehlal, Shivnath Sahebrao Patil
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20180044345
    Abstract: Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 15, 2018
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik, Dhakhada Chetana Bharatbhai, Khichi Kuldip Fatehlal, Shivnath Sahebrao Patil
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20160362411
    Abstract: Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 15, 2016
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik, Dhakhada Chetana Bharatbhai, Khichi Kuldip Fatehlal, Shivnath Sahebrao Patil