Patents by Inventor Shixia Zhou

Shixia Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of agomelatine and its intermediate
    Patent number: 8653281
    Abstract: A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy- 1-naphthy)ethyl]phthalimide is provided and inclues reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1 -naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II) to alkaline hydrolysis and acetylation, to obtain agomelatine.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: February 18, 2014
    Assignee: NHWA Pharma. Corporation
    Inventors: Guisen Zhang, Daopeng Chen, Yanqin Ma, Xiangping Yang, Shixia Zhou, Liang Chen
  • Use of aryl piperazine derivatives in manufacturing medicants for treating pain
    Patent number: 8420652
    Abstract: The use of aryl piperazines of formula (I) in manufacturing a medicament for treating acute pain, neuropathic pain or receptive nociceptive pain in mammals including human beings is disclosed.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: April 16, 2013
    Assignee: NHWA Pharma Corporation
    Inventors: Guisen Zhang, Lin Guo, Xiangping Yang, Xiangqing Xu, Jianqi Li, Guan Wang, Yanqin Ma, Shuming Hu, Shicheng Liu, Shixia Zhou
  • BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE
    Publication number: 20110306638
    Abstract: The invention relates to a benzisoxazolyl piperidine derivative having the following general formula, a salt or a hydrate thereof, wherein R, X, Y, R? and T are defined as in the specification. Such compounds have serotonin system modulating effects such as antagonizing effect on 5-HT2A and inhibitory effect on 5-HT reuptake. The compounds have good analgesic and sedative activities with mild toxic and side effects. The invention also relates to a composition comprising said derivative and the use thereof.
    Type: Application
    Filed: December 22, 2009
    Publication date: December 15, 2011
    Applicant: NHWA PHARMA. CORPORATION
    Inventors: Jianqi Li, Guan Wang, Guisen Zhang, Na Lv, Guangjun Jiao, Shicheng Liu, Shixia Zhou
  • PROCESS FOR THE MANUFACTURE OF AGOMELATINE AND ITS INTERMEDIATE
    Publication number: 20110130571
    Abstract: A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide is provided and includes reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1-naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide (II) to alkaline hydrolysis and acetylation, to obtain agomelatine.
    Type: Application
    Filed: July 23, 2009
    Publication date: June 2, 2011
    Inventors: Guisen Zhang, Daopeng Chen, Yanqin Ma, Xiangping Yang, Shixia Zhou, Liang Chen
  • USE OF ARYL PIPERAZINE DERIVATIVES IN MANUFACTURING MEDICANTS FOR TREATING PAIN
    Publication number: 20100331340
    Abstract: The use of aryl piperazines of formula (I) in manufacturing a medicament for treating acute pain, neuropathic pain or receptive nociceptive pain in mammals including human beings is disclosed.
    Type: Application
    Filed: January 15, 2009
    Publication date: December 30, 2010
    Inventors: Guisen Zhang, Lin Guo, Xiangping Yang, Xiangqing Xu, Jianqi Li, Guan Wang, Yanqin Ma, Shuming Hu, Shicheng Liu, Shixia Zhou