Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.

Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.

Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.

Abstract: An electrical power coupler is configured to convey electrical power upon detecting that a compatible other coupler is properly aligned and no undesirable operating conditions are detected. The power coupler includes a first ferromagnetic metal adjacent a first magnet, a hall sensor for detecting a magnetic field in the first ferromagnetic metal, and at least two first electrical contacts. A control unit is in electrical communication with the power conductors, and includes an electrical switch operable to selectively allow a flow of electricity from a power source through the associated power conductors when the hall sensor detects the magnetic field, such as when the first electrical contacts are in contact with at least two second electrical contacts of another electrical power coupler. The second electrical contacts make contact with the first electrical contacts upon proper alignment of a correspondingly configured other electrical power coupler.

Abstract: An electrical power coupler is configured to convey electrical power upon detecting that a compatible other coupler is properly aligned and no undesirable operating conditions are detected. The power coupler includes a first ferromagnetic metal adjacent a first magnet, a hall sensor for detecting a magnetic field in the first ferromagnetic metal, and at least two first electrical contacts. A control unit is in electrical communication with the power conductors, and includes an electrical switch operable to selectively allow a flow of electricity from a power source through the associated power conductors when the hall sensor detects the magnetic field, such as when the first electrical contacts are in contact with at least two second electrical contacts of another electrical power coupler. The second electrical contacts make contact with the first electrical contacts upon proper alignment of a correspondingly configured other electrical power coupler.