Patents by Inventor Shiyu GUO

Shiyu GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11912814
    Abstract: A preparation method of a flexible polyurethane foam includes the following steps of: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain a vegetable oil polyol for flexible polyurethane foam; and (3) using the vegetable oil polyol for flexible polyurethane foam obtained in the step (2) as the unique polyol, and subjecting the same and an isocyanate polyol to a foaming reaction to obtain the flexible polyurethane foam.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: February 27, 2024
    Assignee: NANJING TECH UNIVERSITY
    Inventors: Kai Guo, Zheng Fang, Junjie Tao, Wei He, Chengkou Liu, Jindian Duan, Xin Li, Ning Zhu, Jiangkai Qiu, Shiyu Guo, Pingkai Ouyang
  • Publication number: 20240059764
    Abstract: The present invention relates to the field of biomedicine, and provides an isolated antigen-binding protein and a derived protein thereof, which can specifically bind to Staphylococcus aureus ? toxin and neutralize the biological activity thereof. Also provided is a use of the isolated antigen-binding protein and derived protein thereof in the field of treating and/or preventing Staphylococcus aureus infection.
    Type: Application
    Filed: January 11, 2022
    Publication date: February 22, 2024
    Applicants: Starmab Biologics (suzhou) Co., Ltd., Starshining Biologics (Shanghai) Co., Ltd.
    Inventors: Maomao An, Xiran Qiu, Simin Chen, Shiyu Guo, Bohua Li
  • Publication number: 20230165218
    Abstract: A cat scratcher kit and method of assembly. The kit includes first and second corrugated cardboard blocks, each corrugated cardboard block having top and bottom curvilinear surfaces of exposed open cardboard flutes such that the top surface of the first corrugated cardboard block nests coextensively with the bottom surface of the second corrugated cardboard block in a first orientation. Each of the first and second corrugated cardboard blocks have a notch configured therein such that the first and second corrugated cardboard blocks are joined to one another through joinder of the notches forming a corrugated cardboard perch having a substantially X-profile in a second orientation.
    Type: Application
    Filed: November 30, 2021
    Publication date: June 1, 2023
    Inventors: Jacob Dominguez, Aimee Diskin, Julie Widenhofer, Michael Russo, Hanah Rosenberg, Lisa Davis, Shiyu Guo
  • Publication number: 20220324949
    Abstract: Provided are an antibody that binds to Staphylococcus aureus alpha-hemolysin or a fragment thereof, and the use of the antibody or the fragment thereof for preventing or treating Staphylococcus aureus infections. The antibody is obtained through screening by means of the strategies of attenuated immunity and virulent screening of alpha-hemolysin, and the antibody has high affinity to alpha-hemolysin, can effectively block the hemolysis effect of alpha-hemolysin, has proved significant protective or therapeutic effects in the alpha-hemolysin sepsis model, MRSA bacteremia model and MRSA lung infection model, and has a synergistic effect with antibiotics, which is a beneficial supplement to existing antibiotic therapy for Staphylococcus aureus.
    Type: Application
    Filed: September 18, 2020
    Publication date: October 13, 2022
    Inventors: Maomao AN, Lichun WANG, Pan GAO, Jian LIN, Yuanying JIANG, Hui SHEN, Simin CHEN, Shiyu GUO, Wei FANG
  • Publication number: 20210251189
    Abstract: A pet toy having a body configured in a shape that is attractive to a cat and a consumer. The pet toy is in the form of a pet toy body, the pet toy body having a cavity, the cavity having a smooth surface and diameter. A rigid insert having a smooth surface and a coefficient of friction less than that of the pet toy body and diameter equal to the diameter of the cavity. The cavity is sized such that a retained portion of the rigid insert is captured within the cavity and a portion of the rigid sphere extends outside of said spherical cavity such that during play, a portion of the rigid insert is in contact with a support surface for the pet toy.
    Type: Application
    Filed: February 14, 2020
    Publication date: August 19, 2021
    Applicant: Worldwise, Inc.
    Inventors: Margaret Wong, Lisa Davis, Aimee Diskin, Shiyu Guo, Hannah Rosenberg, Michael Risso
  • Publication number: 20210230350
    Abstract: A preparation method of a flexible polyurethane foam includes the following steps of: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain a vegetable oil polyol for flexible polyurethane foam; and (3) using the vegetable oil polyol for flexible polyurethane foam obtained in the step (2) as the unique polyol, and subjecting the same and an isocyanate polyol to a foaming reaction to obtain the flexible polyurethane foam.
    Type: Application
    Filed: April 12, 2021
    Publication date: July 29, 2021
    Inventors: Kai GUO, Zheng FANG, Junjie TAO, Wei He, Chengkou LIU, Jindian DUAN, Xin LI, Ning ZHU, Jiangkai QIU, Shiyu GUO, Pingkai OUYANG
  • Publication number: 20190119493
    Abstract: A vegetable oil polyol for flexible polyurethane foam, a preparation method and application thereof. The method includes the following steps: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; and (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain the vegetable oil polyol for flexible polyurethane foam.
    Type: Application
    Filed: December 14, 2018
    Publication date: April 25, 2019
    Inventors: Kai GUO, Zheng FANG, Junjie TAO, Wei He, Chengkou LIU, Jindian DUAN, Xin LI, Ning ZHU, Jiangkai QIU, Shiyu GUO, Pingkai OUYANG
  • Patent number: D994233
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: August 1, 2023
    Assignee: Worldwise, Inc.
    Inventors: Ingrid VonderWishche, Aimee Diskin, Brooke Rogers, Lyle Koenig, Sarah Frank, Shiyu Guo