Patents by Inventor Shiyue Duan

Shiyue Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cationic polymers formed from amino group-bearing monomers and heterocyclic linkers
    Patent number: 9163107
    Abstract: The present invention is directed to a design of and a method to synthesize polycations for gene (DNA and RNA) delivery. According to this design, the polycations (also said cationic polymers) are formed by polymerization of endogenous monomers bearing sufficient amino groups through degradable bonds with linker molecules. The amino group-bearing monomers are those naturally existing or nontoxic to human body. The linker molecules are those which are not only degradable to nontoxic fragments but also able to release the amino group-bearing monomers in their native state upon degradation. Some examples for the endogenous amino group-bearing monomers are spermine and spermidine (or their derivatives). Examples for the degradable chemical bonds formed between the amino group-bearing monomers are imines.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: October 20, 2015
    Assignee: SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Tuo Jin, Shiyue Duan
  • CATIONIC POLYMERS FORMED FROM AMINO GROUP-BEARING MONOMERS AND HETEROCYCLIC LINKERS
    Publication number: 20130310536
    Abstract: The present invention is directed to a design of and a method to synthesize polycations for gene (DNA and RNA) delivery. According to this design, the polycations (also said cationic polymers) are formed by polymerization of endogenous monomers bearing sufficient amino groups through degradable bonds with linker molecules. The amino group-bearing monomers are those naturally existing or nontoxic to human body. The linker molecules are those which are not only degradable to nontoxic fragments but also able to release the amino group-bearing monomers in their native state upon degradation. Some examples for the endogenous amino group-bearing monomers are spermine and spermidine (or their derivatives). Examples for the degradable chemical bonds formed between the amino group-bearing monomers are imines.
    Type: Application
    Filed: January 5, 2012
    Publication date: November 21, 2013
    Inventors: Tuo Jin, Shiyue Duan