Patents by Inventor Shizuo Shimada

Shizuo Shimada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-ganglioside GD.sub.1 A monoclonal antibody MZ, MZ-producing cells and MZ-containing reagent
    Patent number: 5192662
    Abstract: Disclosed is a novel anti-ganglioside GD.sub.1a monoclonal antibody (MZ) which is capable of recognizing ganglioside GD.sub.1a but is practically incapable of recognizing GalCer, LacCer, Gb.sub.3, Gb.sub.4, GA.sub.1, GA.sub.2, GM.sub.2, GM.sub.3, GD.sub.1b, GT.sub.1b, GQ.sub.1b, Fuc-GM.sub.1, nLc.sub.4 and sialosyl nLc.sub.4 ; MZ-producing cells; an MZ-containing reagent; and a method for the detection or quantification of GD.sub.1a using the reagent, e.g., to diagnose cancer, systematic lupus erythematosus and diseases resulting from organic injury of the nervous system.
    Type: Grant
    Filed: September 7, 1988
    Date of Patent: March 9, 1993
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Shizuo Shimada, Daiji Iwata, Wakao Sato
  • Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation containing same
    Patent number: 4726947
    Abstract: Cells of a microorganism, such as Mycobacterium tuberculosis, belonging to the genus Mycobacterium are disrupted in distilled water or a suitable buffer solution, and then centrifuged or filtrated to remove the cell wall residue. To the aqueous cell-free extract is added a polyvalent metal salt or an antibiotic, such as streptomycin sulfate, which acts as a flocculant to form a precipitate. The precipitate consists essentially of sugar, protein, lipid, and nucleic acid. Owing to its high antitumor and adjuvant activities as well as its slight side effects, it can be used as antitumor and adjuvant preparations.
    Type: Grant
    Filed: June 8, 1981
    Date of Patent: February 23, 1988
    Assignee: Matsui Toatsu Chemicals, Inc.
    Inventors: Shizuo Shimada, Tadashi Sudo, Hitoshi Inoue, Yoshio Furutani, Yoshikazu Fujisawa
  • Thermally-denatured deoxyribonucleic acid MD-011 and antitumor agent
    Patent number: 4579941
    Abstract: Thermally-denatured DNA MD-011 having an antitumor activity was obtained by heating the substance separated from the disrupted cells of bacteria belonging to genus Mycobacterium.
    Type: Grant
    Filed: August 13, 1982
    Date of Patent: April 1, 1986
    Assignee: Mitsuitoatsu Chemicals, Inc.
    Inventors: Yoshio Furutani, Hiroshi Yamamoto, Tamotsu Fukuda, Shizuo Shimada, Osamu Yano