Patents by Inventor Shmuel Cabilly
Shmuel Cabilly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120004138Abstract: The present invention includes apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls wherein at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells. The present invention further includes apparatus for electrophoresis separation having a substantially closed electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in a stagger format.Type: ApplicationFiled: June 30, 2011Publication date: January 5, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Shmuel CABILLY, Uri Yogev, Ilana Margalit
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Patent number: 7923221Abstract: The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.Type: GrantFiled: April 13, 1995Date of Patent: April 12, 2011Assignees: Genentech, Inc, City of HopeInventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
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Publication number: 20110011741Abstract: Apparatus for conducting electrophoresis therein includes a chamber with a gel matrix. The chamber has a first sealed region and a second sealed region, and an anode within the first sealed region of the chamber and in contact with the gel matrix, and a cathode within the second sealed region and in contact with the gel matrix. At least one of the electrodes also provides ions for driving the electrophoresis. The apparatus further includes a matrix with at least one sparingly water-soluble salt.Type: ApplicationFiled: June 17, 2010Publication date: January 20, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Patent number: 7824532Abstract: Apparatus for conducting electrophoresis therein includes a chamber with a gel matrix. The chamber has a first sealed region and a second sealed region, and an anode within the first sealed region of the chamber and in contact with the gel matrix, and a cathode within the second sealed region and in contact with the gel matrix. At least one of the electrodes also provides ions for driving the electrophoresis. The apparatus further includes a matrix with at least one sparingly water-soluble salt.Type: GrantFiled: January 28, 2002Date of Patent: November 2, 2010Assignee: Life Technologies CorporationInventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Publication number: 20070074973Abstract: The present invention includes apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls wherein at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells. The present invention further includes apparatus for electrophoresis separation having a substantially closed electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in a stagger format.Type: ApplicationFiled: September 6, 2006Publication date: April 5, 2007Inventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Patent number: 7122104Abstract: The present invention includes apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls wherein at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells. The present invention further includes apparatus for electrophoresis separation having a substantially closed electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in a stagger format.Type: GrantFiled: February 24, 2003Date of Patent: October 17, 2006Assignee: Ethrog Biotechnology, Ltd.Inventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Patent number: 7053178Abstract: Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (?2GPI) monoclonal antibodies (mAbs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-?2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.Type: GrantFiled: November 29, 2004Date of Patent: May 30, 2006Assignee: Yeda Research Development Co., LTDInventors: Miri Blank, Shmuel Cabilly, Yehuda Shoenfeld, Ephraim Katchalski-Katzir
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Publication number: 20050107584Abstract: Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (?2GPI) monoclonal antibodies (mAbs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-?2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.Type: ApplicationFiled: November 29, 2004Publication date: May 19, 2005Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.Inventors: Miri Blank, Shmuel Cabilly, Yehuda Shoenfeld, Ephraim Katchalski-Katzir
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Patent number: 6825319Abstract: Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (&bgr;2GPI) monoclonal antibodies (mabs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-&bgr;2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.Type: GrantFiled: January 8, 2001Date of Patent: November 30, 2004Assignee: Yeda Research and Development Co., Ltd.Inventors: Miri Blank, Shmuel Cabilly, Yehuda Shoenfeld, Ephraim Katchalski-Katzir
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Publication number: 20030121783Abstract: The present invention includes apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls wherein at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells.Type: ApplicationFiled: February 24, 2003Publication date: July 3, 2003Inventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Patent number: 6562213Abstract: Apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls, at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The loading sites are offset with respect to the wells. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells, and apparatus for electrophoresis separation having an electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in an alternating staggered format. A method for simultaneous loading of multiple samples into the electrophoresis apparatus.Type: GrantFiled: August 30, 2000Date of Patent: May 13, 2003Assignee: Ethrog Biotechnology Ltd.Inventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Publication number: 20020134680Abstract: An apparatus and method for conducting electrophoresis, includes a cassette, gel, and electrolyte solution in contact with the gel. The electrolyte solution has high capacity and low conductivity properties, so that low volumes of electrolyte solution can be used.Type: ApplicationFiled: March 7, 2002Publication date: September 26, 2002Inventors: Shmuel Cabilly, Ilana Margalit, Uri Yogev, Tim Updyke
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Publication number: 20020112960Abstract: Apparatus for conducting electrophoresis therein includes a chamber with a gel matrix. The chamber has a first sealed region and a second sealed region, and an anode within the first sealed region of the chamber and in contact with the gel matrix, and a cathode within the second sealed region and in contact with the gel matrix. At least one of the electrodes also provides ions for driving the electrophoresis. The apparatus further includes a matrix with at least one sparingly water-soluble salt.Type: ApplicationFiled: January 28, 2002Publication date: August 22, 2002Inventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Patent number: 6379516Abstract: Apparatus for conducting electrophoresis separation therein. The apparatus includes a chamber having therein a body of separating gel for carrying therein an electrophoresis separation and electrodes for connecting the chamber to an external electrical power source, thereby driving the electrophoresis separation. According to the invention at least one of the electrodes also providing ions for driving the electrophoresis separation. In one preferred embodiment, the apparatus is a cassette substantially closed before, during and after electrophoresis separation. According to an aspect of the invention the pH in the body of separating gel is substantially constant during the electrophoresis separation.Type: GrantFiled: October 22, 1996Date of Patent: April 30, 2002Assignee: Ethrog Biotechnology Ltd.Inventors: Shmuel Cabilly, Uri Yogev, Ilana Margalit
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Patent number: 6331415Abstract: The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.Type: GrantFiled: June 10, 1988Date of Patent: December 18, 2001Assignee: Genentech, Inc.Inventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
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Patent number: 5865974Abstract: A substantially closed cassette for conducting therein electrophoresis separation which includes a closed chamber, the chamber includes therein a body of gel, at least one ion source having a volume smaller than the volume of the gel for providing ions for driving the electrophoresis separation and electrodes for connecting the cassette to an external electrical power source, thereby enabling to drive the electrophoresis separation.Type: GrantFiled: April 26, 1996Date of Patent: February 2, 1999Assignee: Ethrog Biotechnology Ltd.Inventors: Shmuel Cabilly, Uri Yogev
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Patent number: 5582702Abstract: A substantially closed cassette for conducting therein electrophoresis separation which includes a closed chamber, the chamber includes therein a body of gel, means for providing ions for driving the electrophoresis separation and electrodes for connecting the cassette to an external electrical power source, thereby enabling to drive the electrophoresis separation.Type: GrantFiled: April 26, 1995Date of Patent: December 10, 1996Assignee: Ethrog Biotechnology Ltd.Inventors: Shmuel Cabilly, Uri Yogev
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Patent number: 4816567Abstract: Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglobulins into immunologically active form.Type: GrantFiled: April 8, 1983Date of Patent: March 28, 1989Assignee: Genentech, Inc.Inventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel