Patents by Inventor Shogo HASHIZUME

Shogo HASHIZUME has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-((1H-PYRAZOL-4-YL)METHYL)-3-(PHENYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS GPR139 ANTAGONISTS FOR THE TREATMENT OF E.G. DEPRESSION
    Publication number: 20230348435
    Abstract: The present invention refers to compounds of formula (I). The present invention also relates to compounds of formula (I) for use as G Protein coupled Receptor 139 (GPR139) antagonists in methods of medical treatment of e.g. depression, Alzheimer's disease schizophrenia, drug addiction, sleep disorders, pain, and attention deficit hyperactivity disorder. Exemplary compounds are e.g. 1-(OH-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2H-imidazol-2-one derivatives and related compounds. The present description discloses the synthesis and characterisation of exemplary compounds, pharmacological data thereof, as well as exemplary tablet formulations comprising the compounds of the invention (e.g. page 100 to page 143; examples 1 to 167; test examples 1 and 2; tables 1 to 4).
    Type: Application
    Filed: May 20, 2021
    Publication date: November 2, 2023
    Inventors: Tomoaki HASUI, Satoshi MIKAMI, Toru YAMASHITA, Shinji NAKAMURA, Shinji MORIMOTO, Toshihiro IMAEDA, Kazuaki TAKAMI, Masaki DAINI, Hiroyuki KAKEI, Minoru NAKAMURA, Fumie YAMAGUCHI, Chunxiang WANG, Sachie TAKASHIMA, Shogo HASHIZUME
  • Substituted pyrido[4,3-b]indoles and azepino[4,5-b]indoles as inhibitors of cGAS
    Patent number: 11414422
    Abstract: 1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: August 16, 2022
    Assignee: The Rockefeller University
    Inventors: Lodoe Lama, Thomas Tuschl, Daisuke Tomita, Dinshaw Patel, J. Fraser Glickman, Taku Kamei, Michael Miller, Yasutomi Asano, Rei Okamoto, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Mayako Michino, Takanobu Kuroita
  • INHIBITORS OF cGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS
    Publication number: 20220185812
    Abstract: Tri-cyclyl nitrogen-containing heterocyclic compounds are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
    Type: Application
    Filed: March 12, 2020
    Publication date: June 16, 2022
    Applicants: The Rockefeller University, Memorial Sloan-Kettering Cancer Center
    Inventors: Daisuke TOMITA, Lodoe LAMA, Thomas TUSCHL, Dinshaw PATEL, J. Fraser GLICKMAN, Taku KAMEI, Michael MILLER, Yasutomi ASANO, Rei OKAMOTO, Shogo HASHIZUME, Jumpei AIDA, Toshihiro IMAEDA, Mayako MICHINO, Takanobu KUROITA
  • 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-b]INDOLE INHIBITORS OF cGAS FOR TREATING AUTOINFLAMMATORY DISEASES
    Publication number: 20210155625
    Abstract: 1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
    Type: Application
    Filed: February 5, 2019
    Publication date: May 27, 2021
    Applicants: The Rockefeller University, Memorial Sloan-Kettering Cancer Center
    Inventors: Lodoe LAMA, Thomas TUSCHL, Daisuke TOMITA, Dinshaw PATEL, J. Fraser GLICKMAN, Taku KAMEI, Michael MILLER, Yasutomi ASANO, Rei OKAMOTO, Shogo HASHIZUME, Jumpei AIDA, Toshihiro IMAEDA, Mayako MICHINO, Takanobu KUROITA