Abstract: A functional evaluation system of hippocampus that includes: an acquisition unit that acquires image data representing a hippocampus of a subject; and an identification unit that identifies volume data representing a volume of a left hippocampal-amygdaloid transition area of the subject, in accordance with the image data.

Abstract: It is an object of the present invention to provide a novel therapeutic agent for glioblastoma. In accordance with the present invention, it was found that compounds having an antagonistic action against AMPA receptor are useful as therapeutic agents for glioblastoma, particularly primary glioblastoma de novo with a high malignancy level, and the object has been attained.

Abstract: The present invention is to provide a method of treatment which inhibits proliferation and invasion of brain tumor cells in developing animal brain tumor cells, and a method for measuring proliferation/invasion activity of brain tumor cells, in the brain tumor cells, preferably, in glioblastoma. Proliferation and invasion of brain tumor cells are inhibited by regulating Ca2+ permeability by glutamate receptor subunits in developing animal brain tumor cells. Regulation of Ca2+ permeability by glutamate receptor subunits can be conducted by introducing the GluR2 gene into AMPA-type glutamate receptors in brain tumor cells. Further, the present invention provides a method for measuring proliferation/invasion activity of brain tumor cells by detecting/measuring the expression of glutamate receptor subunits in developing animal brain tumor cells.

Abstract: It is an object of the present invention to provide a novel therapeutic agent for glioblastoma. In accordance with the present invention, it was found that compounds having an antagonistic action against AMPA receptor are useful as therapeutic agents for glioblastoma, particularly primary glioblastoma de novo with a high malignancy level, and the object has been attained.