Abstract: A door lock device for a vehicle includes: a support member; a latch supported to be rotatable around a first shaft member supported by the support member and rotating in a first direction and engaging with a striker provided in a vehicle main body when a vehicle door is closed; a pawl supported to be rotatable around a second shaft member supported by the support member and restricting rotation of the latch in a second direction by engaging with the latch engaged with the striker; and an elastic member having one and other end portions and elastically deformed by an external force, in which in a state where the elastic member is elastically deformed, the one end portion engages with the pawl, the other end portion is supported by the support member, and an elastic force is applied to the pawl to bias the pawl to the latch side.

Abstract: A surfactant composition for a formed sand including 80 to 99.8 mass % of a compound (A) represented by formula (1); 0.1 to 10 mass % of a compound (B) represented by formula (2); and 0.1 to 10 mass % of an amphoteric surfactant (C): R1O-(EO)n—SO3M1??(1) wherein R1 represents a hydrocarbon group having 6 to 22 carbons, EO represents oxyethylene group, n is 1 to 10, and M1 represents an alkali metal, an alkaline earth metal, ammonium or an organic ammonium; R2O—SO3M2??(2) wherein R2 represents a hydrocarbon group having 6 to 22 carbons, and M2 represents an alkali metal, an alkaline earth metal, ammonium or an organic ammonium.

Abstract: A core forming device is equipped with a kneading tank in which raw materials of a core are kneaded, a raw material supply unit that supplies the raw materials to the kneading tank, a mold that accommodates a kneaded material including the raw materials kneaded in the kneading tank and that forms the core, a piston that injects the kneaded material into the mold, a position sensor that detects a position of the piston, and a control unit that controls a supply amount of the raw materials supplied to the kneading tank from the raw material supply unit. The control unit determines the supply amount of the raw materials based on a difference between the position of the piston upon completion of injection and a reference position of the piston.

Abstract: A core molding method capable of satisfactorily exhausting a gaseous body such as gas or water vapor that is generated inside an outer shell layer when a raw material is cured is provided. A core molding method according to one aspect of the present disclosure is a molding method of a core formed of a raw material including a binder and sand, and includes: filling a cavity of a molding die with the raw material; curing the raw material to form an outer shell layer; inserting a tip end part of an exhaust pipe having an internal pin inserted therein and an exhaust hole closed by the internal pin into a part surrounded by the outer shell layer through an opening provided in the molding die; and moving the internal pin and opening the exhaust hole.

Abstract: A door lock device for a vehicle includes: a support member; a latch supported to be rotatable around a first shaft member supported by the support member and rotating in a first direction and engaging with a striker provided in a vehicle main body when a vehicle door is closed; a pawl supported to be rotatable around a second shaft member supported by the support member and restricting rotation of the latch in a second direction by engaging with the latch engaged with the striker; and an elastic member having one and other end portions and elastically deformed by an external force, in which in a state where the elastic member is elastically deformed, the one end portion engages with the pawl, the other end portion is supported by the support member, and an elastic force is applied to the pawl to bias the pawl to the latch side.

Abstract: A core forming device is equipped with a kneading tank in which raw materials of a core are kneaded, a raw material supply unit that supplies the raw materials to the kneading tank, a mold that accommodates a kneaded material including the raw materials kneaded in the kneading tank and that forms the core, a piston that injects the kneaded material into the mold, a position sensor that detects a position of the piston, and a control unit that controls a supply amount of the raw materials supplied to the kneading tank from the raw material supply unit. The control unit determines the supply amount of the raw materials based on a difference between the position of the piston upon completion of injection and a reference position of the piston.

Abstract: A core molding method capable of satisfactorily exhausting a gaseous body such as gas or water vapor that is generated inside an outer shell layer when a raw material is cured is provided. A core molding method according to one aspect of the present disclosure is a molding method of a core formed of a raw material including a binder and sand, and includes: filling a cavity of a molding die with the raw material; curing the raw material to form an outer shell layer; inserting a tip end part of an exhaust pipe having an internal pin inserted therein and an exhaust hole closed by the internal pin into a part surrounded by the outer shell layer through an opening provided in the molding die; and moving the internal pin and opening the exhaust hole.

Abstract: An object of the present invention is to provide a pharmaceutical preparation containing the drug as an active ingredient, which is capable of improving the QOL and the compliance of the patient who doses the drug while avoiding any excessive increase in the plasma level of the drug by means of controlling the in vivo release rate of the drug and also by means of reducing the frequency of taking the drug.

Abstract: Medicinal preparations containing a drug 2-amino-3-cyano-5-2(2-fluorophenyl) -4-methylpyrrole wherein the QOL and compliance of patients taking this drug can be improved and an unnecessary increase in the drug concentration in the plasma can be prevented by sustaining the release speed of the drug in vivo and lowering the administration frequency of the drug. That is, sustained release oral preparations containing 2-amino-3-cyano-5-(2-fluorophenyl)-4-methylpyrrole as the active ingredient.

Abstract: It is a primary object of the present invention to provide a process for producing a pharmaceutical solid dispersion using a twin-screw compounding extruder, the pharmaceutical solid dispersion including hydroxypropyl methylcellulose as a carrier which is superior in elution property of pharmaceutical ingredients and in stability and the pharmaceutical solid dispersion being satisfactory for subsequent pharmaceutical preparations.

Abstract: Medicinal preparations containing a drug 2-amino-3-cyano-5-(2-fluorophenyl)-4-methylpyrrole wherein the QOL and compliance of patients taking this drug can be improved and an unnecessary increase in the drug concentration in the plasma can be prevented by sustaining the release speed of the drug in vivo and lowering the administration frequency of the drug. That is, sustained release oral preparations containing 2-amino-3-cyano-5-(2-fluorophenyl)-4-methylpyrrole as the active ingredient.

Abstract: The object of the present invention is to provide a tablet that dissolves rapidly in the oral cavity (fast soluble tablets) that can be produced by a simple method without special preparation technology. The present invention is a fast soluble tablet which comprises two features: 1 the tablet base component is a sugar alcohol or the like, and 2 a kneaded mixture of a drug and a sugar alcohol or the like is subjected to compressive shaping prior to drying in the process when compressive shaped for preparing tablets by wet granulation. The fast soluble tablet of the present invention can be produced by a modification of the conventional tableting method, and possesses sufficient physico-chemical stability.

Abstract: A sustained release capsule excellent in adhesion characteristics in the gastrointestinal tract, stability and so on is provided. The capsule is characterized in that a polymer excellent in initial adhesion and a polymer excellent in shape-retaining ability are dispersed in a liquid substance in the capsule, that a physiologically active substance is dispersed or dissolved in the liquid substance and that the moisture content in the whole preparation is not more than 2%.

Abstract: The object of this invention is to provide a process for producing a solid dispersion, which has overcome the disadvantages of the conventional production technology for solid dispersions. The invention comprises employing a twin-screw extruder in the production of a solid dispersion. In accordance with the invention, a solid dispersion can be expediently produced without heating a drug and a polymer to or beyond their melting points and without using an organic solvent for dissolving both components and the resulting solid dispersion has excellent performance characteristics.