Patents by Inventor Shohachi Nakajima
Shohachi Nakajima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5272164Abstract: Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine are also disclosed: ##STR2## wherein all the substituents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.Type: GrantFiled: February 28, 1992Date of Patent: December 21, 1993Assignee: Kirin Beer Kabushiki KaishaInventors: Toshio Izawa, Tomoko Kashiwabara, Shohachi Nakajima, Nobuyuki Ogawa
-
Patent number: 5223508Abstract: Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboxyimidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine are also disclosed: ##STR2## wherein all the substituents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.Type: GrantFiled: February 28, 1992Date of Patent: June 29, 1993Assignee: Kirin Beer Kabushiki KaishaInventors: Toshio Izawa, Tomoko Kashiwabara, Shohachi Nakajima, Nobuyuki Ogawa
-
Patent number: 5166347Abstract: Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine is also disclosed: ##STR2## wherein all the substitutents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.Type: GrantFiled: December 22, 1989Date of Patent: November 24, 1992Assignee: Kirin Beer Kabushiki KaishaInventors: Toshio Izawa, Tomoko Kashiwabara, Shohachi Nakajima, Nobuyuki Ogawa
-
Patent number: 4959460Abstract: Disclosed is an anthracycline compound of the formula (I): ##STR1## wherein Ra is -R.sup.1, ##STR2## or --OR.sup.3, R.sup.1 being (1) alkyl, alkenyl, alkynyl, fluoroalkyl, aryl or aralkyl, or (2) alkyl, alkenyl, alkynyl. fluoroalkyl, aryl or aralkyl having carboxyl, azido, amino, hydroxy, alkoxy or a halogen atom; R.sup.2 being R.sup.1, a hydrogen atom or hydroxy; and R.sup.3, which may be the same or different when one substituent has two R.sup.3 's, being R.sup.1 or a hydrogen atom; or the formula (II): ##STR3## wherein Rb is -R.sup.1, ##STR4## or --OR.sup.3, R.sup.1, R.sup.2 and R.sup.3 being as defined above; and R.sup.4 being the same as R.sup.3 except that methyl is not included; or an acid addition salt thereof.This compound can be contained as an active ingredient in an antitumor agent, whereby good results are attainable.Type: GrantFiled: August 29, 1989Date of Patent: September 25, 1990Assignee: Kirin Beer Kabushiki KaishaInventors: Shohachi Nakajima, Nobuyasu Komeshima
-
Patent number: 4888418Abstract: An anthracycline compound (13-deoxycarminomycin) selected from the group consisting of anthracycline compounds represented by the following formula ##STR1## R1 is a hydroxy group, R2 represents a hydrogen atom or a hydroxyl group,R3 is a hydrogen atom,R4 represents one of the following groups (a) to (d) ##STR2## and if R2 is hydroxyl, R4 is not (d).Type: GrantFiled: March 11, 1988Date of Patent: December 19, 1989Assignee: Kirin Beer Kabushiki KaishaInventors: Hiroyuki Kawai, Shohachi Nakajima, Tomio Takeuchi
-
Patent number: 4877870Abstract: Disclosed is a process for producing a 10-hydroxyanthracycline of the following formula (II) which comprises reacting a compound of the following formula (I) or an acid addition salt thereof with an N-oxide of a tertiary amine ##STR1## wherein: R.sup.1 through R.sup.6 each designate any of H, OH and OCH.sub.3 ; R.sup.7 designates any of H, OH and a sugar residue; and R.sup.8 designates any of C.sub.2 H.sub.5, COCH.sub.3, CH(OH)CH.sub.3, CH(OH)CH.sub.2 (OH) and COCH.sub.2 OH. In accordance with this process, it is possible to efficiently introduce a hydroxyl group into the 10-position of an anthracycline having no substitutent at the same position thereof.Type: GrantFiled: June 30, 1987Date of Patent: October 31, 1989Assignee: Kirin Beer Kabushiki KaishaInventors: Hamao Umezawa, deceased, Kuniaki Tatsuta, Hiroyuki Kawai, Shohachi Nakajima
-
Patent number: 4855414Abstract: An anthracycline compound, R20X2, of the following formula (II) is produced by a process which comprises subjecting an anthracycline compound, R20X3, of the following formula (I) or a salt thereof to reaction in the co-presence of (1) acetone and/or dimethylformamide and (2) an aqueous solution containing ammonium ion and/or trialkylamine. ##STR1## The anthracycline compound, R20X2, can be produced not only by the cultivation of actinomycetes but also, in accordance with the process as shown above, by chemical conversion of the anthracycline compound, R20X3, in a high yield.Type: GrantFiled: June 30, 1987Date of Patent: August 8, 1989Assignee: Kirin Beer Kabushiki KaishaInventors: Hamao Umezawa, Atsuo Odagawa, Shiro Kataoka, Shohachi Nakajima
-
Patent number: 4833241Abstract: Disclosed is an anthracycline compound of the following formula (I) or an acid addition salt thereof: ##STR1## These compounds are useful as intermediates in the synthesis of an anthracycline compound, M-R20X or M-R20X2, which has antitumor activity.Type: GrantFiled: June 30, 1987Date of Patent: May 23, 1989Assignee: Kirin Beer Kabushiki KaishaInventors: Hamao Umezawa, Hiroyuki Kawai, Shohachi Nakajima
-
Patent number: 4710564Abstract: Disclosed is a novel anthracycline compound of the following formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are each a hydroxyl group or a hydrogen atom and satisfy the condition that, when R.sup.2 is a hydroxyl group, R.sup.1 is a hydroxyl group or a hydrogen atom, whereas, when R.sup.2 is a hydrogen atom, R.sup.1 is a hydrogen atom, or an acid addition salt thereof.These compounds can be contained as active ingredients in antitumor agents, whereby good results are attainable.Type: GrantFiled: January 14, 1986Date of Patent: December 1, 1987Assignee: Microbial Chemistry Research FoundationInventors: Noboru Otake, Kuniaki Tatsuta, Shigeyuki Mizobuchi, Nobuyasu Komeshima, Shohachi Nakajima, Hiroyuki Kawai, Atsuo Odagawa