Patents by Inventor Shoichi Chokai
Shoichi Chokai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6191149Abstract: A pharmaceutical composition comprising a compound of the following general formula [I] or its salt. wherein R1 represents aryl or a heteroaromatic group. R2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino, or phenyl. R3 and R4 independently represent hydrogen or alkyl or R3 and R4 taken together with the adjacent N atom represent a 5- through 7-membered cyclic amino group. A represents a single bond C2-10 alkylene. W represents O, S, or (CH2)n (where CH may be substituted by alkyl; n is an integer of 1 or 2). X, Y, and Z may be the same or different and each represents CH (which may be substituted by alkyl), or N. Provided, however, that the case in which X, Y, and Z concurrently represent CH is excluded. The compound of the invention has excellent neuronal death inhibitory activity and is useful as a therapeutic drug for cerebrovascular diseases.Type: GrantFiled: June 16, 1999Date of Patent: February 20, 2001Assignee: Nippon Shinyaku, Co., Ltd.Inventors: Shoichi Chokai, Yojiro Ukai, Tomiyoshi Aoki, Kyoichi Ideguchi
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Patent number: 5945426Abstract: A pharmaceutical composition comprising a compound of the following general formula ?I! or its salt. ##STR1## wherein R.sup.1 represents aryl or a heteroaromatic group. R.sup.2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino, or phenyl. R.sup.3 and R.sup.4 independently represent hydrogen or alkyl or R.sup.3 and R.sup.4 taken together with the adjacent N atom represent a 5- through 7-membered cyclic amino group. A represents C.sub.2-10 alkylene. W represents O, S, or (CH).sub.n (where CH may be substituted by alkyl; n is an integer of 1 or 2). X, Y, and Z may be the same or different and each represents CH (which may be substituted by alkyl), or N. Provided, however, that the case in which X, Y, and Z concurrently represent CH is excluded. The compound of the invention has excellent neuronal death inhibitory activity and is useful as a therapeutic drug for cerebrovascular diseases.Type: GrantFiled: March 7, 1997Date of Patent: August 31, 1999Assignee: Nippon Shinyaku Co., Ltd.Inventors: Shoichi Chokai, Yojiro Ukai, Tomiyoshi Aoki, Kyoichi Ideguchi
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Patent number: 5589477Abstract: The object of the present invention is to obtain new class of compounds which have improving effect on learning and memory disorders with good selectivity in central nervous system and little side effects and then to provide a good medicine for treatment of dementia.The present invention relates to the compounds represented by the following general formula or their pharmacologically acceptable salts and the drugs of improving learning or memory disorders comprising them as active ingredients. ##STR1## (wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, hydroxy, alkoxy, trifluoromethyl or halogen. A represents methyl, trifluoromethyl, or tert-butyl. Y represents O or NH.Type: GrantFiled: February 26, 1993Date of Patent: December 31, 1996Assignee: Nippon Shinyaku Company, LimitedInventors: Shoichi Chokai, Tomiyoshi Aoki, Kiyoshi Kimura
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Patent number: 5432195Abstract: The present invention relates to a compound expressed by the following general formula (I), pharmacologically-acceptable salt thereof and pharmaceutical composition mainly comprising the same. ##STR1## wherein R.sup.1 is hydrogen, halogen or alkyl; R.sup.2 is alkoxycarbonyl, aralkyloxycarbonyl, carboxy, hydroxyalkyl or acyloxyalkyl; Y is >CHOH, >CHOZ, >CH.sub.2 or >CO; and Z is acyl.The pharmaceutical composition of the present invention is effective for prevention and therapy of arteriosclerosis, ischemic heart diseases, cerebral infarction and restenosis after PTCA operations.Type: GrantFiled: January 5, 1994Date of Patent: July 11, 1995Assignee: Nippon Shinyaku Company LimitedInventors: Shoichi Chokai, Shinji Ohmachi, Masafumi Taira
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Patent number: 5342845Abstract: The object of the invention is to provide a novel compound having serotonin antagonist activity.The invention is directed to an indolecarboxamide derivative of the following general formula [I] and a serotonin antagonist composition comprising the same derivative as an active ingredient. ##STR1## (wherein R.sup.1 is a lower alkyl and R.sup.2 is hydrogen, a halogen, a lower alkyl or a lower alkoxy.)The compound of the invention is effective as a gastrointestinal motor activity regulator, antimigraine, antipsychotic or antianxiety drug. The compound is also effective as a therapeutic drug for dementia or orthostatic hypotension.Type: GrantFiled: February 26, 1993Date of Patent: August 30, 1994Assignee: Nippon Shinyaku Company LimitedInventors: Shoichi Chokai, Tomiyoshi Aoki, Yojiro Ukai
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Patent number: 5102882Abstract: Pyroglutamide derivatives have been found to be useful as nootropic agents for administration to humans and animals.Type: GrantFiled: February 26, 1991Date of Patent: April 7, 1992Assignee: Nippon Shinyaku Co., Ltd.Inventors: Koyishi Kimura, Shoichi Chokai, Toshio Tomita, Masahiro Kise, Kenichi Nakamura
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Patent number: 4831055Abstract: Compounds of formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is hydrogen, halogen or alkyl and R.sup.2 is hydrogen or alkyl are useful to reduce serum lipids in animals, including humans.Type: GrantFiled: June 8, 1987Date of Patent: May 16, 1989Assignee: Nippon Shinyaku Co., Ltd.Inventors: Yoshiaki Yoshikuni, Shoichi Chokai, Takayuki Ozaki, Hirotsugu Yoshida, Haruo Tanaka, Jun Segawa
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Patent number: 4755523Abstract: Abietamide derivatives of the formula I ##STR1## wherein X is NZ wherein Z is hydrogen, alkyl, unsubstituted or substituted phenyl or X is a sulphur atom; when X is NZ, V is nitrogen, W is , and R is hydrogen or alkyl and when X is a sulphur atom, V is , W is nitrogen, and R is hydrogen, alkyl, phenyl or --CH.sub.2 COOR'; wherein R' is hydrogen or alkyl and is a single or double bond, are useful for treating hyperlipemia and particularly for the prevention and therapy of arteriosclerosis.Type: GrantFiled: February 17, 1987Date of Patent: July 5, 1988Assignee: Nippon Shinyaku Co., Ltd.Inventors: Yoshiaki Yoshikuni, Shoichi Chokai, Yukio Fujita, Takayuki Ozaki
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Patent number: 4711898Abstract: 4-Quinolone derivatives of the present invention are useful for their anti-inflammatory, anti-allergenic, antitussive, expectorant and antithrombotic activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.Type: GrantFiled: September 27, 1985Date of Patent: December 8, 1987Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiroshi Enomoto, Tadatoshi Nomura, Yoshiaki Aoyagi, Shoichi Chokai, Yukio Fujita, Tatsuhiko Kono, Masao Murase, Kichiro Inoue, Masahiro Adachi
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Patent number: 4594345Abstract: 3-methylflavone derivatives which are useful in the treatment of allergies, asthma and inflammation.Type: GrantFiled: June 24, 1983Date of Patent: June 10, 1986Assignee: Nippon Shinyaku Co. Ltd.Inventors: Hiroshi Enomoto, Tadatoshi Nomura, Yoshiaki Aoyagi, Shoichi Chokai, Masao Murase, Kichiro Inoue, Ichiro Shirahase
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Patent number: 4526894Abstract: 4-Hydroxy-2-quinolone derivatives are useful for their anti-inflammatory, anti-allergenic, antitussive and expectorant activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.Type: GrantFiled: June 21, 1983Date of Patent: July 2, 1985Assignee: Nippon Shinyaku Co. Ltd.Inventors: Hiroshi Enomoto, Tadatoshi Nomura, Yoshiaki Aoyagi, Shoichi Chokai, Tatsuhiko Kono, Masao Murase, Kichiro Inoue, Masahiro Adachi
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Patent number: 4237132Abstract: A series of new 4,6-disubstituted 2-morpholinone derivatives were prepared either by a reaction of corresponding epoxide derivatives with phenylglycine derivatives or by the reaction of isopropanol derivatives with carboxylic acid derivatives. The new morpholinone derivatives are useful for the prevention or the treatment of arteriosclerosis.Type: GrantFiled: June 4, 1976Date of Patent: December 2, 1980Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4162331Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: January 24, 1977Date of Patent: July 24, 1979Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4094991Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: January 24, 1977Date of Patent: June 13, 1978Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4064252Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: June 4, 1976Date of Patent: December 20, 1977Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki