Patents by Inventor Shoichi Kusumoto
Shoichi Kusumoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7838549Abstract: The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.Type: GrantFiled: February 4, 2005Date of Patent: November 23, 2010Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Shoichi Kusumoto, Michael Sobel, Masahiro Wakao
-
Patent number: 7320867Abstract: A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone.Type: GrantFiled: September 8, 2003Date of Patent: January 22, 2008Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Shoichi Kusumoto, Michael Sobel
-
Publication number: 20070213523Abstract: The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.Type: ApplicationFiled: February 4, 2005Publication date: September 13, 2007Applicants: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Shoichi Kusumoto, Michael Sobel, Masahiro Wakao
-
Patent number: 7183067Abstract: A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.Type: GrantFiled: August 6, 2003Date of Patent: February 27, 2007Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Hideki Hayashi, Shoichi Kusumoto, Michael Sobel
-
Publication number: 20060030699Abstract: A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound.Type: ApplicationFiled: September 8, 2003Publication date: February 9, 2006Inventors: Yasuo Suda, Akio Arano, Shoichi Kusumoto, Michael Sobel
-
Publication number: 20060014220Abstract: A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.Type: ApplicationFiled: August 6, 2003Publication date: January 19, 2006Inventors: Yasuo Suda, Akio Arano, Hideki Hayashi, Shoichi Kusumoto, Michael Sobel
-
Patent number: 5998595Abstract: Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.Type: GrantFiled: October 30, 1997Date of Patent: December 7, 1999Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Shoichi Kusumoto, Koichi Fukase
-
Patent number: 5548077Abstract: 2-Aminopyridine derivatives having a bifunctional or unifunctional structure and capable of serving as reactants in synthetically converting organic compounds, such as carbohydrates, proteins, lipids or polymer resins, to desired conjugated structures suited for various purposes and detectable by fluorescence spectrometry with high sensitivity, a fluorescent labeling agent comprising the same, and methods of their production are disclosed.Type: GrantFiled: September 23, 1994Date of Patent: August 20, 1996Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: Shoichi Kusumoto, Koichi Fukase, Sumihiro Hase
-
Patent number: 5386033Abstract: 2-Aminopyridine derivatives having a bifunctional or unifunctional structure and capable of serving as reactants in synthetically converting organic compounds, such as carbohydrates, proteins, lipids or polymer resins, to desired conjugated structures suited for various purposes and detectable by fluorescence spectrometry with high sensitivity, a fluorescent labeling agent comprising the same, and methods of their production are disclosed.Type: GrantFiled: March 15, 1993Date of Patent: January 31, 1995Assignee: Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)Inventors: Shoichi Kusumoto, Sumihiro Hase, Koichi Fukase
-
Patent number: 4211898Abstract: A headphone is designed to have two resonant peaks for simulating loudspeaker reproduction. The headphone comprises a housing in which an electroacoustic transducer with a diaphragm is positioned, wherein the housing is formed with a rearward cavity positioned adjacent to the diaphragm remote from the listener's ear to provide an acoustic compliance to the generated acoustic energy. In order to generate the two resonant peaks to simulate a sensation of realism as if the listener is hearing sound from a loudspeaker, the rearward cavity is communicated with the atmosphere through apertures. The acoustic compliance of the rearward cavity coacts with the apertures to produce two resonant peaks at frequencies corresponding to the frequencies of the peaks which occur in a signal from the loudspeaker.Type: GrantFiled: July 10, 1978Date of Patent: July 8, 1980Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Nobuhisa Atoji, Takashi Matsumoto, Shoichi Kusumoto, Kazue Sato, Mitsuhiro Hasegawa
-
Patent number: 4101536Abstract: Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the .alpha.-position thereof,Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group or an -L-seryl-D-isoglutamine group;Salts of such derivatives; the method of preparing such derivatives and their salts; the derivatives and their salts having potent immunoadjuvant activities and antitumor activity and being applicable as the agent for the immunotherapy of cancer for humans and animals.Type: GrantFiled: June 23, 1977Date of Patent: July 18, 1978Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Yuichi Yamamura, Tetsuo Shiba, Ichiro Azuma, Shoichi Kusumoto, Tadamasa Hirayama, Tsuneo Kusama