Patents by Inventor Shoichi Mizutaki

Shoichi Mizutaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing glutamine derivative
    Patent number: 5780677
    Abstract: N-chloroacetylglutamine is produced by reacting chloroacetyl chloride with an alkaline aqueous solution of glutamine the presence of a water-immiscible organic solvent, separating an aqueous layer by liquid-liquid separation, and crystallizing N-chloroacetyl-glutamine from the aqueous layer under acidic conditions. N-Chloroacetyl-glutamine useful as an intermediate for producing glycyl-L-glutamine which has higher stability than L-glutamine and is used as a component of an infusion solution can be obtained with high efficiency at low cost.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: July 14, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kazumi Amatsu, Yoshiyuki Yamada, Yoshikazu Mori, Shoichi Mizutaki, Masaji Kasai, Shinji Tomioka
  • Process for producing alanylglutamine
    Patent number: 5550283
    Abstract: Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below.in accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: August 27, 1996
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kunimi Inoue, Yoshiyuki Yamada, Kazumi Amatsu, Yukiteru Mimura, Yasunori Nakaguchi, Hiroyuki Shinmura, Yasuyuki Ono, Yutaka Osawa, Shoichi Mizutaki, Masaji Kasai, Shinji Tomioka
  • Process for producing alanylgutamine
    Patent number: 5380934
    Abstract: Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below.In accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: January 10, 1995
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kunimi Inoue, Yoshiyuki Yamada, Kazumi Amatsu, Yukiteru Mimura, Yasunori Nakaguchi, Hiroyuki Shinmura, Yasuyuki Ono, Yutaka Osawa, Shoichi Mizutaki, Masaji Kasai, Shinji Tomioka