Patents by Inventor Shoichiro Ozaki
Shoichiro Ozaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8853424Abstract: The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(1) R3—[—X—B(ZR1)—Y—]n—R4,??(2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(3) R3—[—X—B(ZR1)—]n—R4,??(4) R3—[—B(ZR2)—W—]n—R4,??(5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,??(6) R3—B(OH)2,??(7) R3—B(ZR1)—X—B(ZR2)—R4,??(8) R3—B(R1)—O—B(R2)—R4,??(9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,??(10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,??(11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(12) [R3—X—B(ZR1)—Y]2B(ZR2),??(13) wherein each symbol is as defined in the DESCRIPTION.Type: GrantFiled: August 11, 2009Date of Patent: October 7, 2014Assignee: Japan Science and Technology AgencyInventors: Katsuhiko Mikoshiba, Nobuyuki Nukina, Shoichiro Ozaki, Kouzo Hamada, Jun-Ichi Goto, Akinobu Suzuki, Etsuko Ebisui, Akiko Terauchi
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Patent number: 8017809Abstract: A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R1 and R2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R3 represents a hydrogen atom; —(CH2)m—NR4R5; —CO—(CH2)m—NR4R5; —COCH(NH2)R6; —CHR7R8; —CH2CH(NH2)—R9; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R1 and R2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH2, S, SO2, CH2OCH2, OCH2, OCH2CH2OCH2, OCH2OCH2CH2 and CH2OCH2CH2, or a salt thereof, and a composition for contrType: GrantFiled: November 24, 2006Date of Patent: September 13, 2011Assignee: Japan Science and Technology AgencyInventors: Katsuhiko Mikoshiba, Shoichiro Ozaki, Akinobu Suzuki, Takeshi Nakamura, Kyoko Nakamura, legal representative, Aiko Nakamura, legal representative
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Publication number: 20110212919Abstract: The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(1) R3—[—X—B(ZR1)—Y—]n—R4,??(2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(3) R3—[—X—B(ZR1)—]n—R4,??(4) R3—[—B(ZR2)—W—]n—R4,??(5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,??(6) R3—B(OH)2,??(7) R3—B(ZR1)—X—B(ZR2)—R4,??(8) R3—B(R1)—O—B(R2)—R4,??(9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,??(10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,??(11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(12) [R3—X—B(ZR1)—Y]2B(ZR2),??(13) wherein each symbol is as defined in the DESCRIPTION.Type: ApplicationFiled: August 11, 2009Publication date: September 1, 2011Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Katsuhiko Mikoshiba, Nobuyuki Nukina, Shoichiro Ozaki, Kouzo Hamada, Jun-Ichi Goto, Akinobu Suzuki, Etsuko Ebisui, Akiko Terauchi
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Publication number: 20100087645Abstract: A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R1 and R2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R3 represents a hydrogen atom; —(CH2)m—NR4R5; —CO—(CH2)m—NR4R5; —COCH(NH2)R6; —CHR7R8; —CH2CH(NH2)—R9; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R1 and R2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH2, S, SO2, CH2OCH2, OCH2, OCH2CH2OCH2, OCH2OCH2CH2 and CH2OCH2CH2, or a salt thereof, and a composition for contrType: ApplicationFiled: November 24, 2006Publication date: April 8, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Katsuhiko Mikoshiba, Shoichiro Ozaki, Akinobu Suzuki, Takeshi Nakamura
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Patent number: 5292913Abstract: Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.Type: GrantFiled: September 24, 1992Date of Patent: March 8, 1994Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shoichiro Ozaki, Yutaka Watanabe, Akira Awaya, Yusaku Ishizuka
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Patent number: 5264605Abstract: A process for preparing myoinositol polyphosphoric acid from myoinositol via a polyacylmyoinositol, a process for preparing a polysilyl-polyacylmyoinositol from a polyacylmyoinositol, and a process for preparing an optically active myoinositol polyphosphoric acid from the above product or a polysilylmyoinositol.Type: GrantFiled: February 20, 1991Date of Patent: November 23, 1993Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shoichiro Ozaki, Yutaka Watanabe
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Patent number: 5252707Abstract: There are disclosed a novel inositol-1,4,5-triphosphoric acid derivative, inositol-1,3,4-triphosphoric acid derivative, inositol-1,3,4,5-tetraphosphoric acid derivative, and a bonded substance of the same and a protein. They control the metabolic process of an organism concerned with calcium ions to thereby exert a medicinal virtue.Type: GrantFiled: May 15, 1991Date of Patent: October 12, 1993Assignee: Mitsui Toatsu Chemicals IncorporatedInventors: Shoichiro Ozaki, Yutaka Watanabe, Masato Hirata, Akira Awaya
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Patent number: 5202444Abstract: Optically active diols and hydroxycarboxylic acids and their esters are produced by deriving 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol from 1L-chiro-inositol as an asymmetric source, followed by introduction of a selected class of sterically hindering and asymmetrically reactive groups into the first-mentioned compound and by subsequent reduction of the resulting compound. Seven specific inositols are also derivable from synthesis of those ultimate compounds.Type: GrantFiled: November 21, 1991Date of Patent: April 13, 1993Assignee: The Yokohama Rubber Co., Ltd.Inventors: Shoichiro Ozaki, Takahiko Akiyama, Kunio Kageyama, Morihisa Machida
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Patent number: 5091549Abstract: A method of synthesizing D-myoinositol-1-phosphate from 1,2-(R.sup.1)-3-R.sup.2 -myoinositol compounds of the formula ##STR1## wherein R.sup.1 is a bridging type protective group bonded to two oxygen atoms at the 1- and 2-position, and R.sup.2 is a protective group coupled to the oxygen atom at the 3-position. D-Myoinositol-1-phosphate is useful as an intermediate for the production of inositol-1,4,5-triphosphate.Type: GrantFiled: August 31, 1990Date of Patent: February 25, 1992Assignee: The Yokohama Rubber Company, Ltd.Inventors: Shoichiro Ozaki, Takahiko Akiyama, Naoto Takechi, Kunio Kageyama, Morihisa Machida
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Patent number: 4952717Abstract: Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.Type: GrantFiled: October 20, 1987Date of Patent: August 28, 1990Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shoichiro Ozaki, Yutaka Watanabe, Akira Awaya, Yusaku Ishizuka
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Patent number: 4497815Abstract: A 1-(N-substituted carbamoyl)-5-fluorouracil derivative represented by the following general formula: ##STR1## R is a 4-alkoxycyclohexyl group-containing radical which is 2,3,4-trimethoxycyclohexcylethyl, 2,3,4-trimethoxycyclohexyl, 2,4-dimethoxycyclohexylmethyl, 3,4-dimethoxycyclohexylethyl, 2,4-dimethoxycyclohexyl, 2,4,5-trimethoxycyclohexyl, 3,4-dimethoxycyclohexylmethyl, 3,4,5-trimethoxycyclohexyl, 4-ethoxycyclohexyl or 4-ethoxycyclohexylmethyl. The compounds are carcinostatic agents. The compounds are used in a therapeutically effective amount in the presence of a carrier.Type: GrantFiled: January 5, 1983Date of Patent: February 5, 1985Assignee: Shoichiro OzakiInventors: Shoichiro Ozaki, Tomonori Hoshiko, Tomio Ogasawara
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Patent number: 4376768Abstract: N-(6-chloro-2-pyridyl)-3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-ca rboxamide 1,1-dioxide that is a novel benzothiazine derivative. The compound is characterized by a low degree of toxicity and a low incidence of gastric disorders and useful as an anti-inflammatory agent.Type: GrantFiled: June 16, 1981Date of Patent: March 15, 1983Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Shoichiro Ozaki, Hideya Kobayashi, Haruki Mori, Takafumi Kitano, Hiroshi Kawazura, Yutaka Okazaki
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Patent number: 4376119Abstract: N-(6-fluoro-2-pyridyl)-3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-ca rboxamide 1,1-dioxide that is a novel benzothiazine derivative. The compound is characterized by a low degree of toxicity and a low incidence of gastric disorders and useful as an anti-inflammatory agent.Type: GrantFiled: June 16, 1981Date of Patent: March 8, 1983Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Shoichiro Ozaki, Hideya Kobayashi, Haruki Mori, Hiroshi Kawazura, Yutaka Okazaki, Takafumi Kitano, Mikio Kumakura, Takuo Nakano
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Patent number: 4267326Abstract: New uracil derivatives of the general formula: ##STR1## wherein R.sup.1 stands for a hydrogen atom or a grouping of the formula: ##STR2## R.sup.2 for a hydrogen atom, an alkyl group or a phenyl group and R.sup.3 for an alkyl group or a phenyl group, with the proviso that when both R.sup.1 and R.sup.2 stand for a hydrogen atom, R.sup.3 stands for a phenyl group or a straight chain alkyl group with 3.about.11 carbon atoms, that when R.sup.1 stands for a hydrogen atom and R.sup.2 for methyl group, R.sup.3 stands for an alkyl group with at least 2 carbon atoms or a phenyl group, and that when R.sup.1 stands for a hydrogen atom and R.sup.3 for methyl group, R.sup.2 stands for an alkyl group with at least 2 carbon atoms or a phenyl group. These uracil derivatives are prepared by reacting 5-fluorouracil with an .alpha.-haloalkyl carboxylate or with an aldehyde diacylate or by hydrolyzing a 1,3-bis(acyloxymethyl)-5-fluorouracil with an acid or alkali.Type: GrantFiled: February 26, 1979Date of Patent: May 12, 1981Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shoichiro Ozaki, Yoshimasa Ike, Katsutoshi Ishikawa, Haruki Mori
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Patent number: 4071519Abstract: 1-Carbamoyl-5-fluorouracil derivatives represented by the formula ##STR1## wherein R represents alkyl containing 3-8 carbon atoms are effective oral anti-tumor agents with low toxicity.Type: GrantFiled: November 5, 1975Date of Patent: January 31, 1978Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shoichiro Ozaki, Haruki Mori
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Patent number: 4032524Abstract: 1-Carbamoyl-5-fluorouracil derivatives represented by the formula ##STR1## wherein R.sub.1 represents methyl, ethyl, phenyl or cyclohexyl and R.sub.2 represents hydrogen or is the same as R.sub.1 are effective anti-metabolites useful in treating lymphatic leukemia L1210, sarcoma 180A and Ehrlich ascites carcinoma in mice.Type: GrantFiled: September 24, 1976Date of Patent: June 28, 1977Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shoichiro Ozaki, Haruki Mori