Patents by Inventor Shoji Nishiyama

Shoji Nishiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100093871
    Abstract: Disclosed is an agent for prevention or treatment of iron overload disorders, comprising 22?-methoxyolean-12-ene-3?,24(4?)-diol or a pharmacologically acceptable salt thereof.
    Type: Application
    Filed: March 19, 2008
    Publication date: April 15, 2010
    Applicant: MEIJI SEIKA KAISHA, LTD.
    Inventors: Hideaki Kagehara, Shoji Nishiyama
  • Patent number: 7153979
    Abstract: A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: wherein R1 represents a hydroxyl group, arylmethyloxy, lower alkoxy, or lower alkanoyloxy, R2 represents lower alkyl, lower alkenyl, —CH2OR5, formyl, —COOR6, or —CH2N(R7)R8, or R1 and R2 may combine with each other to form —O—C(R9)R10—O—CH2—, R3 and R4, which may be the same or different, represent a hydrogen atom, a hydroxyl group, lower alkyl, lower alkenyl, aryl, hydroxymethyl, —N(R11)R12, formyl, —COOR6, or —OR13, or R3 and R4 may combine with each other to form oxo, hydroxyimino, or alkylidene and X represents O, CH2, or NH.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: December 26, 2006
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
  • Publication number: 20030195182
    Abstract: A triterpene derivative useful for the treatment of hepatic disorders is disclosed.
    Type: Application
    Filed: February 24, 2003
    Publication date: October 16, 2003
    Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
  • Patent number: 6593364
    Abstract: A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: wherein R1 represents a hydroxyl group, arylmethyloxy, lower alkoxy, or lower alkanoyloxy, R2 represents lower alkyl, lower alkenyl, —CH2OR5, formyl, —COOR6, or —CH2N(R7)R8, or R1 and R2 may combine with each other to form —O—C(R9)R10—O—CH2—, R3 and R4, which may be the same or different represent a hydrogen atom, a hydroxyl group, lower alkyl, lower alkenyl, aryl, hydroxymethyl, —N(R11)R12, formyl, —COOR6, or —OR13, or R3 and R4 may combine with each other to form oxo, hydroxyimino, or alkylidene and X represents O, CH2, or NH.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: July 15, 2003
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
  • Patent number: 6350459
    Abstract: A solubilized cosmetic composition containing an ingredient which is difficult to be dissolved in water, an alkyl-modified carboxyvinyl polymer and a hydroxyalkylated cyclodextrin so as to solubilize the ingredient difficult to be dissolved in water and in particular substantially not containing a surfactant.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: February 26, 2002
    Assignee: Shiseido Company, Ltd.
    Inventors: Kazuaki Suzuki, Wataru Tokue, Kenzo Ito, Shoji Nishiyama
  • Publication number: 20020016481
    Abstract: A triterpene derivative useful for the treatment of hepatic disorders is disclosed.
    Type: Application
    Filed: August 6, 2001
    Publication date: February 7, 2002
    Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
  • Patent number: 6306862
    Abstract: A pharmaceutical composition for treating a hepatic disorder, comprising a triterpene derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof is disclosed: wherein R1 represents a hydroxyl group, alkoxy, alkylcarbonyloxy, or aralkyloxy; R2 represents alkyl, —CH2OR5, wherein R5 represents a hydrogen atom, alkyl, aralkyl, or alkylcarbonyl, formyl, —COOR6, wherein R6 represents a hydrogen atom or alkyl, or —CH2N(R7)R8; or R1 and R2 combine with each other to form —O—CR9(R10)—OCH2—, wherein R9 and R10, which may be the same or different, represent a hydrogen atom, alkyl, or aryl; R3 and R4, which may be the same or different, represent a hydrogen atom, a hydroxyl group, alkyl, hydroxyalkyl, formyl, —COOR11, wherein R11 represents a hydrogen atom or alkyl, or —OR12, wherein R12 represents alkyl, aralkyl, C1-6 alkylcarbonyl, arylcarbonyl, alkenyl, alkenylcarbonyl, or arylalkenylcarbonyl which may be optionally s
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: October 23, 2001
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
  • Patent number: 6201018
    Abstract: A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (IV) or a salt thereof: Y represents a single bond to form a double bond in the ring with Y bonded thereto.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: March 13, 2001
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
  • Patent number: 5853705
    Abstract: An anti-aging cosmetic composition in which is blended an enzymolyzed substance obtained by treating by one or more enzymes an alkali extract of a hypoallergenic rice obtained by treating rice in advance with a proteinase and, preferably, a UV protective agent.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: December 29, 1998
    Assignee: Shiseido Company, Ltd.
    Inventors: Yasukazu Nakayama, Shoji Nishiyama, Yoichi Shimatani, Shigetoyo Sawaki, Katsuhisa Yamada, Kazufumi Naitoh
  • Patent number: 5849272
    Abstract: The ultraviolet absorbing composition in accordance with the present invention comprises the following ingredients (A) and (B):(A) 4-tert-butyl-4'-methoxydibenzoylmethane; and(B) a diester which is liquid at 20.degree. C. and has a structure represented by the following general formula (1):R.sub.1 OOC--(CH.sub.2)n--COOR.sub.2 (1)wherein each of R.sub.1 and R.sub.2 is an alkyl group, an alkenyl group, a hydroxyalkyl group, or a hydroxyalkenyl group each having 1 to 19 carbon atoms, and n is an integer of 0 to 6. In the present invention, crystals of (A) are prevented from depositing by using a diester of (B) togetherwith and an ultraviolet absorbing composition in which (A) can be stably compounded in a high concentration and which exhibits excellent feel of use and safety can be obtained thereby.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: December 15, 1998
    Assignee: Shiseido Co., Ltd.
    Inventors: Katsuya Baba, Toshihito Yabu, Shoji Nishiyama, Kenzo Ito
  • Patent number: 5709849
    Abstract: A cosmetic composition containing (i) a water-soluble polyhydric alcohol having two or more hydroxyl groups and/or a lecithin and (ii) a bivalent metal salt of an organic acid.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: January 20, 1998
    Assignee: Shiseido Company Ltd
    Inventors: Kenzo Ito, Shoji Nishiyama
  • Patent number: 5693255
    Abstract: An oil-in-water type emulsion composition comprising: an amphiphile and a surfactant selected from the substances which can form a gel in an amphiphatic substance-surfactant-water system at a temperature of not lower than ordinary temperatures; oil and water, wherein substantially the total amount of amphiphile and surfactant exist on the boundary surfaces of emulsion particles. The emulsion composition has both the physical properties close to those of an aqueous solution and a creamy feel at the time of use.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: December 2, 1997
    Assignee: Shiseido Co., Ltd.
    Inventors: Toru Okamoto, Satoshi Tomomasa, Hiroyuki Kakoki, Shoji Nishiyama, Hideo Nakajima
  • Patent number: 5658578
    Abstract: A preparation for external application to the skin which comprises disodium adenosine triphosphate and tranexamic acid for prevention of skin roughening and skin improvement. The preparation further contains ginseng extract.
    Type: Grant
    Filed: July 21, 1995
    Date of Patent: August 19, 1997
    Assignee: Shiseido Company, Ltd.
    Inventors: Haruo Ogawa, Shoji Nishiyama, Kenzo Ito
  • Patent number: 5162377
    Abstract: A transparent composition containing a phospholipid, at least one cationic or nonionic surfactant, an oily component, and water.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: November 10, 1992
    Assignee: Shiseido Company, Ltd.
    Inventors: Hiroyuki Kakoki, Shoji Nishiyama, Michihiro Yamaguchi, Yoshimaru Kumano